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FGB Gene Afibrinogenemia, congenital NGS Genetic Test

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FGB Gene Afibrinogenemia, congenital NGS Genetic Test

Short Name: FGB Afibrinogenemia NGS Test

Also known as: Congenital afibrinogenemia, Fibrinogen deficiency, FGB gene disorder

FGB Gene Afibrinogenemia, congenital NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS (Next-Generation Sequencing) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To detect mutations in the FGB gene that cause congenital afibrinogenemia, enabling accurate diagnosis, family screening, and personalized treatment planning.

Test Code
5560
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS (Next-Generation Sequencing)
Step 1

Sample Collection

Provide clinical history and undergo genetic counseling to draw a pedigree chart of affected family members.

Method: Blood draw or saliva collection

Step 2

Laboratory Analysis

A small blood sample or saliva is collected non-invasively by a trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising; resume normal activities.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Provide clinical history and undergo genetic counseling as per pre-test requirements.
2
During the Test:Sample collection via blood draw or saliva; non-invasive and quick.
3
After the Test:Monitor for any discomfort at the collection site; await results in 3-4 weeks.

About This Test

Who Should Get This Test

To detect mutations in the FGB gene that cause congenital afibrinogenemia, enabling accurate diagnosis, family screening, and personalized treatment planning.

How to Prepare

  • Share detailed clinical and family history with the healthcare provider
  • Attend a genetic counseling session before sample collection
  • Ensure proper identification and labeling of the sample

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Early genetic testing for FGB gene mutations is crucial for diagnosing congenital afibrinogenemia, guiding treatment like fibrinogen replacement, and preventing life-threatening bleeding episodes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodBlood draw or saliva collection

Sample Stability

Blood sample at room temperature
Extracted DNA at 4°C
Sample Rejection Criteria:
  • Insufficient sample volume
  • Improperly labeled or contaminated sample
  • Sample collected without required clinical information

Understanding Your Results

Results indicate the presence or absence of mutations in the FGB gene associated with congenital afibrinogenemia.
📊

No pathogenic variants detected

Normal; no mutations causing afibrinogenemia found

📊

Pathogenic variant detected

Confirms diagnosis of congenital afibrinogenemia; genetic counseling recommended

📊

Variant of unknown significance

Further testing and clinical correlation advised

⚠️ When to Consult a Doctor:

If symptoms of excessive bleeding persist, or if genetic test results indicate a mutation, consult a hematologist or genetic specialist for management.

Limitations

  • ⚠May not detect all genetic variants or mutations in the FGB gene
  • ⚠Requires interpretation by a genetic specialist
  • ⚠Does not replace clinical evaluation and other diagnostic tests

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or soreness
  • ●No significant risks associated with saliva collection

Interfering Factors

  • ●Hemolyzed or contaminated blood sample
  • ●Insufficient DNA quantity or quality
  • ●Recent blood transfusions affecting DNA analysis

Frequently Asked Questions

What is FGB Gene Afibrinogenemia?
It is a rare inherited bleeding disorder caused by mutations in the FGB gene, leading to absence of fibrinogen, a protein essential for blood clotting.
How is afibrinogenemia diagnosed?
Diagnosis involves blood tests like CBC, clotting time, and fibrinogen levels, confirmed by genetic testing for FGB gene mutations.
What does the NGS Genetic Test involve?
It uses next-generation sequencing to analyze DNA from blood or saliva samples to detect mutations in the FGB gene.
What is the cost of the test?
The test costs INR 20,000 at DNA Labs India, with free home sample collection available.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection across India for this test.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What are the symptoms of afibrinogenemia?
Symptoms include excessive bleeding from cuts, nosebleeds, easy bruising, heavy menstrual bleeding, and bleeding into joints or organs.
Can afibrinogenemia be treated?
Treatment focuses on managing symptoms, such as fibrinogen replacement therapy during bleeding episodes, and preventive care.
Is genetic testing necessary for diagnosis?
Yes, genetic testing confirms the diagnosis by identifying mutations in the FGB gene, which is crucial for accurate management.
What is the inheritance pattern of afibrinogenemia?
It is inherited in an autosomal recessive pattern, meaning both parents must carry the mutation for a child to be affected.
Are there any risks associated with the test?
The test involves minimal risks, such as bruising from blood draw; no significant risks from saliva collection.
How can I prepare for the test?
Provide clinical history, undergo genetic counseling, and ensure proper sample collection as per instructions.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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