FISH - Follicular Lymphoma (IGH/BCL2) t(14;18) Test
Short Name: FISH IGH/BCL2 t(14;18)
Also known as: IGH/BCL2 FISH, t(14;18) Translocation Test, BCL2 Translocation FISH, FISH Follicular Lymphoma Panel
FISH - Follicular Lymphoma (IGH/BCL2) t(14;18) Test test available at DNA Labs India for ₹9,000. Uses Fluorescence In Situ Hybridization (FISH) on Whole Blood / Bone Marrow / Lymph Node Biopsy / FFPE Tissue samples. Results in Samples are received daily by 4 pm and reports are delivered within 4 working days.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The test detects the IGH/BCL2 t(14;18) translocation by FISH to confirm the diagnosis of follicular lymphoma and help differentiate it from other B-cell lymphomas.
- Test Code
- 3472
- Price
- ₹9,000
- Sample Type
- Whole Blood / Bone Marrow / Lymph Node Biopsy / FFPE Tissue
- Result Time
- Samples are received daily by 4 pm and reports are delivered within 4 working days.
- Fasting Required
- No
- Method
- Fluorescence In Situ Hybridization (FISH)
Sample Collection
No fasting is required. Bring a duly filled Chromosome & FISH analysis Requisition Form (Form 17) as it is mandatory.
Method: Venipuncture, bone marrow aspiration, or tissue biopsy
Laboratory Analysis
A healthcare professional will collect 4 mL whole blood in a sodium heparin tube or perform bone marrow aspiration or lymph node biopsy depending on clinical indication. The sample must not be frozen.
Report Delivery
Samples are shipped at 18–22°C. Lymph node biopsy in normal saline or formalin-fixed paraffin-embedded tissue block should be shipped at room temperature. Do not freeze.
Timeline: Samples are received daily by 4 pm and reports are delivered within 4 working days.
Patient Instructions
About This Test
Who Should Get This Test
The test detects the IGH/BCL2 t(14;18) translocation by FISH to confirm the diagnosis of follicular lymphoma and help differentiate it from other B-cell lymphomas.
How to Prepare
- Use sterile technique for bone marrow aspiration.
- Collect 4 mL whole blood in sodium heparin green top tube.
- Invert tube gently 8–10 times; do not centrifuge.
- For tissue, place 5x5 mm lymph node biopsy in normal saline or submit FFPE block.
- Label immediately and ship at specified temperatures; do not freeze.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"FISH for IGH/BCL2 t(14;18) is the standard cytogenetic confirmation for follicular lymphoma. It detects the translocation that drives BCL2 overexpression and helps distinguish follicular lymphoma from reactive lymphoid proliferations and other B-cell lymphomas."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Frozen whole blood or bone marrow sample
- Clotted or hemolyzed sample
- Unlabeled or mislabeled specimen
- Missing duly filled Chromosome & FISH analysis Requisition Form (Form 17)
- Insufficient sample volume or inadequate tissue
Understanding Your Results
Consult a medical oncologist or hematologist if you have enlarged lymph nodes, unexplained weight loss, persistent fever, night sweats, fatigue, or other symptoms suggestive of lymphoma.
Limitations
- ⚠A negative result does not completely exclude follicular lymphoma.
- ⚠FISH targets the specific t(14;18) translocation and may miss rare variant translocations.
- ⚠Results must be correlated with histopathology, immunophenotyping, and clinical findings.
Risks & Considerations
- ●Mild pain or bruising at blood collection site
- ●Bone marrow aspiration may cause temporary discomfort
- ●Biopsy site bleeding or infection is rare
Interfering Factors
- ●Low tumor burden below FISH sensitivity
- ●Hemodiluted bone marrow sample
- ●Poorly fixed or necrotic tissue
- ●Delayed transport or inappropriate freezing of sample
Compare With Similar Tests
| Test | FISH - Follicular Lymphoma (IGH/BCL2) t(14;18) Test | ||||
|---|---|---|---|---|---|
| Comparison | FISH - Follicular Lymphoma (IGH/BCL2) t(14;18) Test |
Frequently Asked Questions
What is the FISH - Follicular Lymphoma (IGH/BCL2) t(14;18) test?
Why is the t(14;18) translocation important?
Which sample types can be used for this test?
Is fasting required before this test?
How much does the FISH - Follicular Lymphoma test cost in India?
How long does it take to get the report?
Can this test be done at home?
What symptoms suggest follicular lymphoma?
Can this test help diagnose diffuse large B-cell lymphoma?
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