FISH - MET (7q31) Amplification Test
Short Name: MET Amplification Test
Also known as: MET Gene Amplification Test, FISH for MET Amplification, MET (7q31) FISH Test
FISH - MET (7q31) Amplification Test test available at DNA Labs India for ₹9,000. Uses FISH on Formalin fixed paraffin embedded tissue block samples. Results in 4 working days from sample receipt. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the FISH - MET (7q31) Amplification Test is to identify amplifications in the MET gene, which is associated with cancer growth and resistance to EGFR-TKI therapy. It helps in accurate diagnosis, prognosis assessment, and treatment planning for cancers such as NSCLC, breast, and gastric cancer.
- Test Code
- 583
- Price
- ₹9,000
- Sample Type
- Formalin fixed paraffin embedded tissue block
- Result Time
- 4 working days from sample receipt
- Fasting Required
- No
- Method
- FISH
Sample Collection
Consult with your oncologist or healthcare provider for a referral. Ensure the requisition form (Form 17) is duly filled.
Method: Tissue biopsy collection
Laboratory Analysis
A tissue biopsy will be collected by a trained medical professional, typically during a surgical procedure or biopsy session.
Report Delivery
The tissue sample is preserved in formalin and prepared as a paraffin-embedded block for shipping to the laboratory.
Timeline: 4 working days from sample receipt
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the FISH - MET (7q31) Amplification Test is to identify amplifications in the MET gene, which is associated with cancer growth and resistance to EGFR-TKI therapy. It helps in accurate diagnosis, prognosis assessment, and treatment planning for cancers such as NSCLC, breast, and gastric cancer.
How to Prepare
- Submit Formalin fixed paraffin embedded tissue block.
- Ship at room temperature.
- Tissue block must contain at least 10% tumor tissue.
- Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"MET amplification is a key biomarker in non-small cell lung cancer, often indicating resistance to EGFR inhibitors. This test helps in guiding targeted therapy decisions for improved patient outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Inadequate tissue sample with <10% tumor content
- Missing or incomplete requisition form (Form 17)
- Improperly preserved or fixed tissue
- Sample received in unacceptable condition
Understanding Your Results
Positive for Amplification
Increased MET gene copies detected, suggesting potential resistance to EGFR-TKI therapy and guiding targeted treatments.
Negative for Amplification
No MET gene amplification detected, indicating normal copy number and less likelihood of MET-related resistance.
Consult your doctor if you have symptoms like persistent cough, unexplained weight loss, or are undergoing EGFR-TKI therapy and experience disease progression. Early detection can improve treatment outcomes.
Limitations
- ⚠Not applicable for all cancer types
- ⚠Requires expert interpretation by a geneticist
- ⚠Cannot detect all MET mutations, only amplifications
- ⚠Results may be inconclusive with low-quality samples
Risks & Considerations
- ●Minimal risks associated with tissue biopsy, such as infection, bleeding, or discomfort at the biopsy site.
- ●No direct risks from the FISH test itself, as it is performed on collected samples.
Interfering Factors
- ●Poor tissue fixation or preservation
- ●Insufficient tumor cell content (<10%)
- ●Technical errors in FISH procedure
- ●Degraded DNA in tissue sample
Compare With Similar Tests
| Test | FISH - MET (7q31) Amplification Test | EGFR Mutation Test | ALK Rearrangement Test |
|---|---|---|---|
| Comparison | FISH - MET (7q31) Amplification Test |
Frequently Asked Questions
What is the FISH - MET (7q31) Amplification Test?
Why is this test recommended?
What does MET amplification mean for cancer?
How is the sample collected for this test?
What is the cost of the FISH MET Amplification Test?
How long does it take to get results?
Is the test painful?
What are the risks of the biopsy?
How should I prepare for the test?
What if the test is positive for MET amplification?
Can this test be done at home?
Is the test covered by insurance?
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