FISH - RARA (17q21) Variant Translocation Test
Short Name: RARA Variant Translocation FISH
Also known as: RARA break-apart probe test, Variant RARA translocation FISH, FISH for RARA gene rearrangement
FISH - RARA (17q21) Variant Translocation Test test available at DNA Labs India for ₹6,000. Uses Fluorescence in situ hybridization (FISH) on Whole blood or Bone marrow samples. Results in Reports available within 4 days from sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to detect variant RARA gene translocations that are not identified by standard FISH tests, aiding in the diagnosis and treatment planning for acute promyelocytic leukemia (APL).
- Test Code
- 598
- Price
- ₹6,000
- Sample Type
- Whole blood or Bone marrow
- Result Time
- Reports available within 4 days from sample receipt.
- Fasting Required
- No
- Method
- Fluorescence in situ hybridization (FISH)
Sample Collection
Ensure the Chromosome & FISH analysis Requisition Form (Form 17) is duly filled. No specific preparation is required.
Method: Venipuncture for blood, Bone marrow aspiration
Laboratory Analysis
Sample is collected via venipuncture for blood or bone marrow aspiration, placed in sodium heparin tubes.
Report Delivery
Apply pressure to the collection site to prevent bleeding. Keep the sample at room temperature.
Timeline: Reports available within 4 days from sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to detect variant RARA gene translocations that are not identified by standard FISH tests, aiding in the diagnosis and treatment planning for acute promyelocytic leukemia (APL).
How to Prepare
- Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory
- Collect 5 mL whole blood or 4 mL bone marrow in 2 Green Top (Sodium Heparin) tubes
- Ship sample at 18-22°C; do not freeze
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This test is essential for diagnosing variant RARA translocations in APL, guiding targeted therapy and improving patient outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient sample volume
- Improper container or anticoagulant
- Sample not shipped at correct temperature
- Missing or incomplete requisition form
Understanding Your Results
Negative
No variant RARA translocation detected. Correlate with clinical findings.
Positive
Variant RARA translocation detected, suggesting acute promyelocytic leukemia (APL). Requires further clinical evaluation.
Consult a hematologist or oncologist if the test is positive or if symptoms of leukemia persist. Discuss results for appropriate treatment planning.
Limitations
- ⚠May not detect all rare variant translocations
- ⚠Requires skilled interpretation by a cytogeneticist
- ⚠Not a standalone diagnostic; clinical correlation is needed
Risks & Considerations
- ●Minor bruising or pain at the collection site
- ●Rare risk of infection with bone marrow aspiration
Interfering Factors
- ●Poor sample quality or insufficient volume
- ●Improper sample collection or storage
- ●Contamination during processing
Frequently Asked Questions
What is the FISH - RARA (17q21) Variant Translocation Test?
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