FLT3/ITD Allelic Ratio Test
Short Name: FLT3/ITD Test
Also known as: FLT3 ITD Mutation Test, FLT3 Internal Tandem Duplication Test, FLT3 Gene Mutation Test
FLT3/ITD Allelic Ratio Test test available at DNA Labs India for ₹7,500. Uses Fragment Analysis on Bone marrow or Peripheral blood samples. Results in 8-10 days from sample receipt. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The primary purpose of the FLT3/ITD Allelic Ratio Test is to identify the presence and quantify the FLT3/ITD mutation in patients with suspected or confirmed AML. This information is crucial for assessing prognosis, as higher allelic ratios are associated with poorer outcomes. Additionally, it guides treatment decisions, particularly the use of FLT3 inhibitors, which are targeted therapies that can improve survival rates. The test is also used for monitoring treatment response and detecting minimal residual disease.
- Test Code
- 3018
- Price
- ₹7,500
- Sample Type
- Bone marrow or Peripheral blood
- Result Time
- 8-10 days from sample receipt
- Fasting Required
- No
- Method
- Fragment Analysis
Sample Collection
No specific preparation required. Inform the doctor about any medications or health conditions.
Method: Venipuncture for peripheral blood; Bone marrow aspiration for bone marrow sample
Laboratory Analysis
For peripheral blood, a venipuncture will be performed. For bone marrow, an aspiration procedure under local anesthesia.
Report Delivery
Apply pressure to the collection site to prevent bleeding. Monitor for any signs of infection or discomfort.
Timeline: 8-10 days from sample receipt
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the FLT3/ITD Allelic Ratio Test is to identify the presence and quantify the FLT3/ITD mutation in patients with suspected or confirmed AML. This information is crucial for assessing prognosis, as higher allelic ratios are associated with poorer outcomes. Additionally, it guides treatment decisions, particularly the use of FLT3 inhibitors, which are targeted therapies that can improve survival rates. The test is also used for monitoring treatment response and detecting minimal residual disease.
How to Prepare
- Ensure sample is collected in EDTA vacutainer
- Transport immediately to the lab with cool pack
- Label sample correctly with patient details
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"The FLT3/ITD allelic ratio is a critical prognostic marker in AML. A higher ratio often indicates a poorer prognosis, guiding the use of targeted therapies like FLT3 inhibitors."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted sample
- Insufficient sample volume
- Incorrect container or labeling
- Delayed transport beyond stability period
Understanding Your Results
FLT3/ITD Not Detected
No mutation found; standard AML treatment may be considered.
FLT3/ITD Detected with Low Allelic Ratio
Mutation present; may indicate better prognosis compared to high ratio, but targeted therapy could be beneficial.
FLT3/ITD Detected with High Allelic Ratio
Mutation present with high burden; associated with aggressive disease and poorer prognosis; FLT3 inhibitors recommended.
Consult your doctor immediately upon receiving positive results to discuss treatment options. Also, consult if symptoms of AML persist or worsen.
Limitations
- ⚠May not detect all types of FLT3 mutations
- ⚠Requires adequate sample volume and quality
- ⚠Results should be interpreted in conjunction with other clinical and laboratory findings
- ⚠False negatives possible in cases of low tumor burden
Risks & Considerations
- ●Pain or bruising at collection site
- ●Infection risk for bone marrow aspiration
- ●Rare allergic reactions to anesthesia
Interfering Factors
- ●Sample contamination
- ●Improper sample storage or transport
- ●Low DNA quality or quantity
- ●Presence of inhibitors in the sample
Compare With Similar Tests
| Test | FLT3/ITD Allelic Ratio | FLT3/TKD Mutation Test | NPM1 Mutation Test | Bone Marrow Biopsy | Complete Blood Count (CBC) |
|---|---|---|---|---|---|
| Comparison | FLT3/ITD Allelic Ratio | Detects tyrosine kinase domain mutations, complementary to ITD test. | Another common mutation in AML; often tested alongside FLT3. | Provides morphological assessment; genetic tests add molecular detail. | Initial screening test; abnormal results may prompt genetic testing. |
Frequently Asked Questions
What is the FLT3/ITD Allelic Ratio Test?
Why is the FLT3/ITD test important for AML patients?
How is the FLT3/ITD Allelic Ratio Test performed?
What type of sample is needed for this test?
Is fasting required before the test?
How long does it take to receive the test results?
What does a positive FLT3/ITD result mean?
What is the cost of the FLT3/ITD Allelic Ratio Test at DNA Labs India?
Is home collection available for this test?
How accurate is the FLT3/ITD Allelic Ratio Test?
Can this test be used to monitor AML treatment?
Who should consider getting the FLT3/ITD Allelic Ratio Test?
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