HBB Gene Sickle cell anemia NGS Genetic Test
Short Name: HBB Gene Sickle Cell Test
Also known as: Sickle Cell Disease Genetic Test, HBB Gene Mutation Analysis, Sickle Cell Anemia NGS Test
HBB Gene Sickle cell anemia NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of this test is to detect mutations in the HBB gene associated with sickle cell anemia for accurate diagnosis, carrier screening, prenatal testing, and genetic counseling.
- Test Code
- 5621
- ICD Code
- D57.0
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- Yes (8 hours)
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
Inform the lab about any medications, fasting status, and provide clinical history. A genetic counseling session is recommended to draw a pedigree chart.
Method: Blood Draw
Laboratory Analysis
Standard blood draw procedure will be followed by a trained phlebotomist.
Report Delivery
Apply pressure to the puncture site to stop bleeding. Keep the area clean.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to detect mutations in the HBB gene associated with sickle cell anemia for accurate diagnosis, carrier screening, prenatal testing, and genetic counseling.
How to Prepare
- Fast for 8 hours if required
- Bring valid ID and doctor's prescription
- Wear loose clothing for easy blood draw
- Stay hydrated before the test
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Early genetic testing for sickle cell anemia is crucial for accurate diagnosis, management, and informed family planning decisions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted sample
- Insufficient sample volume
- Incorrect labeling or container
Understanding Your Results
Consult a hematologist or geneticist immediately if results are positive for mutations, or if there are symptoms of sickle cell disease.
Limitations
- ⚠May not detect all rare mutations
- ⚠Requires genetic counseling for interpretation
- ⚠Results should be correlated with clinical findings
Risks & Considerations
- ●Minimal risks from blood draw, such as bruising or infection
- ●Psychological impact of genetic results; counseling advised
Interfering Factors
- ●Recent blood transfusion
- ●Contaminated or degraded sample
- ●Incorrect sample storage
Compare With Similar Tests
| Test | HBB Gene Sickle cell anemia NGS Genetic Test | Hemoglobin Electrophoresis | Sickle Cell Solubility Test | Complete Blood Count (CBC) |
|---|---|---|---|---|
| Comparison | HBB Gene Sickle cell anemia NGS Genetic Test | NGS is more comprehensive for detecting a wide range of mutations, while electrophoresis identifies abnormal hemoglobin patterns. | Solubility test is a screening tool, whereas NGS provides definitive genetic diagnosis. | CBC indicates anemia but does not confirm genetic cause; NGS identifies specific mutations. |
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