HBG2 Gene Hereditary persistence of fetal hemoglobin NGS Genetic Test
Short Name: HBG2 HPFH NGS Test
Also known as: Persistent fetal hemoglobin, HPFH genetic test
HBG2 Gene Hereditary persistence of fetal hemoglobin NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS), DNA Sequencing on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample receipt. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To diagnose Hereditary Persistence of Fetal Hemoglobin (HPFH) by identifying mutations in the HBG2 gene using NGS technology, assess genetic risk for associated blood disorders, and support clinical management and genetic counseling.
- Test Code
- 5592
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks from sample receipt
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS), DNA Sequencing
Sample Collection
Obtain clinical history of the patient and conduct a genetic counseling session to draw a pedigree chart of affected family members.
Method: Venipuncture or FTA card collection
Laboratory Analysis
Collect blood sample via venipuncture or use FTA card for one drop of blood, following standard aseptic techniques.
Report Delivery
Label the sample correctly and transport to the laboratory under ambient room temperature conditions for analysis.
Timeline: 3 to 4 weeks from sample receipt
Patient Instructions
About This Test
Who Should Get This Test
To diagnose Hereditary Persistence of Fetal Hemoglobin (HPFH) by identifying mutations in the HBG2 gene using NGS technology, assess genetic risk for associated blood disorders, and support clinical management and genetic counseling.
How to Prepare
- Ensure proper patient identification and sample labeling
- Use sterile collection tubes or FTA cards as specified
- Avoid hemolysis by gentle handling of blood samples
- Store samples at room temperature and ship promptly to the lab
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This NGS test is essential for diagnosing HPFH, which can provide insights into protection against blood disorders like sickle cell anemia and beta-thalassemia. Early detection aids in genetic counseling and management."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood samples
- Insufficient sample volume for DNA extraction
- Improper labeling or documentation
- Contaminated or degraded samples
Understanding Your Results
Positive for pathogenic HBG2 mutation
Confirms HPFH; consult a geneticist for management and family screening.
Negative for pathogenic mutations
HPFH unlikely, but clinical symptoms may warrant additional testing for other hemoglobin disorders.
Variant of uncertain significance (VUS)
Requires genetic counseling and possible retesting or family studies for clarification.
Consult a doctor if you have a family history of HPFH, unexplained high fetal hemoglobin levels, symptoms like mild anemia or jaundice, or for genetic counseling regarding blood disorder risks.
Limitations
- ⚠May not detect all rare or novel mutations in HBG2 gene
- ⚠Results require clinical correlation and genetic counseling
- ⚠Does not replace comprehensive hemoglobinopathy testing if needed
Risks & Considerations
- ●Minimal risk from blood draw, such as bruising or infection
- ●Potential psychological impact from genetic results
- ●Privacy concerns related to genetic data handling
Interfering Factors
- ●Sample contamination or degradation
- ●Insufficient DNA quantity or quality
- ●Technical errors in sequencing or analysis
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Frequently Asked Questions
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Why choose DNA Labs India for this test?
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