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HE4 Human Epididymis Protein 4 Test

DNA Labs India | ISO 9001:2015 Certified

HE4 Human Epididymis Protein 4 Test

Short Name: HE4 Test

Also known as: HE4, Human Epididymis Protein 4, Ovarian Cancer Marker

HE4 Human Epididymis Protein 4 Test test available at DNA Labs India for ₹3,500. Uses CMIA on Serum samples. Results in Same-day reports available if sample is received by 4 pm on Monday or Thursday.. Free home collection in 300+ cities across India.

Tumor Marker TestFemaleAdult🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To aid in the diagnosis, monitoring, and risk assessment of ovarian cancer, often in conjunction with CA-125 and imaging tests.

Test Code
688
Price
₹3,500
Sample Type
Serum
Result Time
Same-day reports available if sample is received by 4 pm on Monday or Thursday.
Fasting Required
No
Method
CMIA
Step 1

Sample Collection

No special preparation required. Inform your doctor about any medications or health conditions.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in your arm by a trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the puncture site with a cotton ball to prevent bruising. Resume normal activities unless advised otherwise.

Timeline: Same-day reports available if sample is received by 4 pm on Monday or Thursday.

Patient Instructions

1
Before the Test:No fasting required. Inform your doctor of all medications and supplements.
2
During the Test:The procedure involves a simple blood draw from the arm, taking a few minutes.
3
After the Test:You may resume normal activities. Mild soreness at the puncture site is common and resolves quickly.

About This Test

Who Should Get This Test

To aid in the diagnosis, monitoring, and risk assessment of ovarian cancer, often in conjunction with CA-125 and imaging tests.

How to Prepare

  • Stay hydrated and avoid strenuous exercise before the test
  • Wear loose clothing for easy arm access
  • Inform the technician of any allergies or bleeding disorders

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"HE4 is a valuable biomarker for ovarian cancer, often used with CA-125 for improved specificity. Early detection can significantly impact treatment outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeSerum
Sample Volume2 mL (1 mL min.)
ContainerSST (Serum Separator Tube)
Collection MethodVenipuncture

Sample Stability

Room Temperature8 hours
Refrigerated4 days
Frozen4 weeks
Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Insufficient sample volume
  • Improper labeling or container

Understanding Your Results

HE4 levels should be interpreted by a healthcare professional in the context of clinical symptoms, medical history, and other test results like CA-125 and imaging.
📊

May indicate ovarian cancer or other conditions; further diagnostic workup is recommended.

Level: Elevated HE4

📊

Suggests lower likelihood of ovarian cancer, but does not rule it out completely, especially if symptoms persist.

Level: Normal HE4

⚠️ When to Consult a Doctor:

If HE4 results are elevated, or if you experience symptoms like persistent abdominal bloating, pelvic pain, or unexplained weight loss, consult a gynecologist or oncologist immediately.

Limitations

  • ⚠Not a standalone diagnostic tool for ovarian cancer
  • ⚠May be elevated in benign conditions like endometriosis or fibroids
  • ⚠Requires correlation with clinical findings and other tests
  • ⚠Sensitivity may vary with tumor stage and type

Risks & Considerations

  • ●Minor pain or bruising at the blood draw site
  • ●Rare risk of infection or dizziness
  • ●Very small chance of excessive bleeding in individuals with bleeding disorders

Interfering Factors

  • ●Hemolyzed or lipemic samples
  • ●Recent infections or inflammatory conditions
  • ●Kidney or liver dysfunction
  • ●Use of certain medications (consult your doctor)

Compare With Similar Tests

TestHE4 Human Epididymis Protein 4 TestCA-125 Test
ComparisonHE4 Human Epididymis Protein 4 Test

Frequently Asked Questions

What is the HE4 Human Epididymis Protein 4 Test?
The HE4 test is a blood test that measures the level of Human Epididymis Protein 4, a biomarker associated with ovarian cancer. It helps in diagnosis, monitoring, and risk assessment.
How is the HE4 test performed?
The test involves drawing a small blood sample from a vein in your arm. The sample is then analyzed in a lab using CMIA technology to measure HE4 levels.
What does a high HE4 level indicate?
A high HE4 level may suggest the presence of ovarian cancer, but it can also be elevated in other conditions. It requires correlation with clinical findings and other tests for accurate diagnosis.
Is the HE4 test accurate for ovarian cancer detection?
HE4 has high specificity for ovarian cancer, especially when combined with CA-125 in the ROMA algorithm. However, no test is 100% accurate, and results should be interpreted by a doctor.
How much does the HE4 test cost in India?
At DNA Labs India, the HE4 test costs INR 3500, including free home sample collection across many cities in India.
Does DNA Labs India offer home sample collection for the HE4 test?
Yes, we offer free home sample collection for online bookings. This service is available in numerous cities across India for convenience.
How long does it take to receive HE4 test results?
Results are typically available on the same day if the sample is collected and received by 4 pm on Monday or Thursday. Reports can be accessed online, via email, or WhatsApp.
Can the HE4 test alone diagnose ovarian cancer?
No, the HE4 test is not used alone. It is part of a comprehensive diagnostic approach that includes CA-125, imaging tests, physical examination, and sometimes biopsy for confirmation.
Are there any risks associated with the HE4 test?
The test is generally safe with minimal risks, such as slight pain or bruising at the puncture site. Rarely, infection or dizziness may occur. Consult your doctor if you have concerns.
What preparation is required before the HE4 test?
No special preparation, such as fasting, is required. You can eat and drink normally. Inform your doctor about any medications you are taking.
What is the ROMA algorithm and how does it relate to HE4?
ROMA (Risk of Ovarian Malignancy Algorithm) uses HE4 and CA-125 levels along with menopausal status to calculate the risk of ovarian cancer in women with pelvic masses. It improves diagnostic accuracy.
Who should consider getting the HE4 test?
Women with symptoms of ovarian cancer, a family history of the disease, abnormal CA-125 levels, or those undergoing treatment for ovarian cancer should consider this test. Consult your gynecologist or oncologist.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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