HLA - B15 (B*15) Test
Short Name: HLA-B15 (B*15)
Also known as: HLA-B15 allele test, B*15 HLA typing, HLA Class I B15 test
HLA - B15 (B*15) Test test available at DNA Labs India for ₹6,000. Uses Reverse SSOP - Luminex on 4 mL (3 mL min.) whole blood in 1 Lavender Top (EDTA) tube OR 6 mL (3 mL min.) whole blood in 1 Yellow Top (ACD) tube samples. Results in Reports are usually delivered within 10-12 days from sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
This test detects the HLA-B15 (B*15) allele to assess genetic susceptibility for ankylosing spondylitis, psoriasis, celiac disease, and carbamazepine-related severe cutaneous adverse drug reactions.
- Test Code
- 3475
- Price
- ₹6,000
- Sample Type
- 4 mL (3 mL min.) whole blood in 1 Lavender Top (EDTA) tube OR 6 mL (3 mL min.) whole blood in 1 Yellow Top (ACD) tube
- Result Time
- Reports are usually delivered within 10-12 days from sample receipt.
- Fasting Required
- No
- Method
- Reverse SSOP - Luminex
Sample Collection
No special preparation or fasting is required. Inform the doctor or laboratory about any recent blood transfusion or transplant history.
Method: Venipuncture
Laboratory Analysis
A standard venipuncture is performed. The sample should be labelled clearly and mixed gently after collection.
Report Delivery
Apply pressure at the puncture site. You can resume normal activities and diet immediately.
Timeline: Reports are usually delivered within 10-12 days from sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
This test detects the HLA-B15 (B*15) allele to assess genetic susceptibility for ankylosing spondylitis, psoriasis, celiac disease, and carbamazepine-related severe cutaneous adverse drug reactions.
How to Prepare
- Use a Lavender Top (EDTA) or Yellow Top (ACD) tube
- Mix the tube gently by inversion
- Ship refrigerated; do not freeze
- Send sample to the laboratory within the stability window
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"HLA-B15 positivity identifies genetic susceptibility, not disease by itself. The result should be interpreted alongside clinical symptoms and family history, particularly before starting carbamazepine in at-risk populations."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Frozen sample
- Hemolysed or clotted sample
- Leaking or broken tube
- Mismatched patient details
- Insufficient sample volume
Understanding Your Results
Not Detected (Negative)
HLA-B15 allele not identified. Does not exclude associated diseases entirely; clinical evaluation remains important.
Detected (Positive)
HLA-B15 allele present. Increased genetic susceptibility to ankylosing spondylitis, psoriasis, celiac disease, or possible carbamazepine hypersensitivity; correlate clinically.
Consult a doctor if you have chronic back pain, joint swelling, psoriasis, unexplained gastrointestinal symptoms, or before starting carbamazepine, especially with a family history or high-risk ethnicity.
Limitations
- ⚠Positive result indicates genetic risk, not definite disease
- ⚠Cannot predict disease severity or clinical course
- ⚠Negative result does not rule out all associated conditions
- ⚠HLA-B15 is common and most carriers never develop associated disease
Risks & Considerations
- ●Mild pain or discomfort at venipuncture site
- ●Bruising
- ●Lightheadedness
- ●Local bleeding (rare)
Interfering Factors
- ●Recent blood transfusion
- ●Allogeneic bone marrow or stem cell transplant
- ●Severe hemolysis
Compare With Similar Tests
| Test | HLA - B15 (B*15) Test | ||
|---|---|---|---|
| Comparison | HLA - B15 (B*15) Test |
Frequently Asked Questions
What is the HLA-B15 (B*15) test?
Why is HLA-B15 testing done?
What sample is needed for the HLA-B15 (B*15) test?
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What does a positive HLA-B15 result mean?
Can a positive result diagnose ankylosing spondylitis or celiac disease?
Is home sample collection available for this test?
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