HLA DNA Typing High Resolution by Next Generation Sequencing (NGS) Test
Short Name: HLA DNA Typing NGS
Also known as: High Resolution HLA DNA Typing by NGS, HLA Genotyping by Next Generation Sequencing, NGS-based HLA Typing
HLA DNA Typing High Resolution by Next Generation Sequencing (NGS) Test test available at DNA Labs India for ₹15,795. Uses Long Range PCR, Full Gene PCR, Next Generation Sequencing on Whole Blood samples. Results in 10-12 days. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The primary purpose of HLA DNA typing high resolution by NGS is to facilitate solid organ transplantation by providing high-resolution typing of HLA genes (A, B, C, DR, DQ) for accurate donor-recipient matching. Additionally, it aids in diagnosing HLA-associated autoimmune diseases, assessing cancer risk, evaluating susceptibility to certain infections, and identifying HLA-related drug hypersensitivity reactions. This information is crucial for personalized medical management and treatment planning.
- Test Code
- 809
- Price
- ₹15,795
- Sample Type
- Whole Blood
- Result Time
- 10-12 days
- Fasting Required
- No
- Method
- Long Range PCR, Full Gene PCR, Next Generation Sequencing
Sample Collection
Ensure a doctor's prescription on letterhead with one photograph each of recipient and donor duly stamped, and a signed consent form for HLA Typing for Solid Organ Transplant (Form 33) is available.
Method: Venipuncture
Laboratory Analysis
A healthcare professional will collect 4 mL of whole blood via venipuncture into a lavender top (EDTA) tube. The process is quick and minimally invasive.
Report Delivery
Label the sample correctly, ship it refrigerated (do not freeze), and ensure it reaches the lab within 96 hours for optimal stability.
Timeline: 10-12 days
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of HLA DNA typing high resolution by NGS is to facilitate solid organ transplantation by providing high-resolution typing of HLA genes (A, B, C, DR, DQ) for accurate donor-recipient matching. Additionally, it aids in diagnosing HLA-associated autoimmune diseases, assessing cancer risk, evaluating susceptibility to certain infections, and identifying HLA-related drug hypersensitivity reactions. This information is crucial for personalized medical management and treatment planning.
How to Prepare
- Collect 4 mL (3 mL min.) whole blood in one lavender top (EDTA) tube
- Ship refrigerated; do not freeze
- Include required documentation: doctor's prescription and signed consent form (Form 33)
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"HLA DNA typing by NGS is vital for successful organ transplantation, helping to minimize rejection risks and improve outcomes. It is also useful in diagnosing HLA-related conditions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Missing or incomplete documentation (prescription, consent form)
- Improper sample container or anticoagulant
- Sample hemolyzed, clotted, or insufficient volume
- Sample stored incorrectly or beyond stability period
Understanding Your Results
Compatible donor-recipient pairing, reducing rejection risk in transplantation
Result type: Matched HLA alleles
Potential risk of graft rejection; may require additional immunosuppression or closer monitoring
Result type: Mismatched HLA alleles
Indicates susceptibility to autoimmune, cancer, or infectious conditions; guide further diagnostic workup
Result type: Disease-associated HLA alleles
May require further validation and consultation with an HLA expert
Result type: Rare or novel alleles
Consult a doctor or transplant specialist if results show mismatches, if you have symptoms of autoimmune disease, or for guidance on transplant planning and immunosuppressive therapy.
Limitations
- ⚠Assay used only for solid organ transplantation (kidney, liver, heart, lung); not for bone marrow or other transplants
- ⚠Results may not detect all rare HLA alleles or mutations
- ⚠Interpretation requires clinical correlation and expert consultation
Risks & Considerations
- ●Minor pain or bruising at blood draw site
- ●Rare risk of infection or hematoma
- ●No significant long-term risks associated with the test itself
Interfering Factors
- ●Contaminated or improperly stored sample
- ●Use of incorrect anticoagulant or tube type
- ●Delay in sample processing beyond stability period
- ●Presence of interfering substances in blood (e.g., high lipid levels)
Compare With Similar Tests
| Test | HLA DNA Typing High Resolution by Next Generation Sequencing (NGS) Test | HLA Low Resolution Typing | Serological HLA Typing | SSO/SSP HLA Typing | Sanger Sequencing HLA Typing |
|---|---|---|---|---|---|
| Comparison | HLA DNA Typing High Resolution by Next Generation Sequencing (NGS) Test |
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