HOXB13 Gene Prostate cancer, familial, association with NGS Genetic Test
Short Name: HOXB13 NGS
Also known as: HOXB13 Gene Mutation Test, Prostate Cancer Genetic Risk Panel, Familial Prostate Cancer NGS
HOXB13 Gene Prostate cancer, familial, association with NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are typically available within 3 to 4 weeks after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify pathogenic variants in the HOXB13 gene that are associated with familial prostate cancer. It helps in risk stratification, guiding screening protocols, and informing family members about their inherited risk. The test is recommended for individuals with a personal or family history of prostate cancer, especially those with early-onset disease or multiple affected relatives.
- Test Code
- 6017
- CPT Code
- 81435
- ICD Code
- Z15.03
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are typically available within 3 to 4 weeks after sample receipt.
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
No special preparation required. However, a genetic counseling session is recommended prior to testing to discuss implications.
Method: Venipuncture or Fingerstick
Laboratory Analysis
Blood sample is drawn by a trained phlebotomist. For FTA card, a simple fingerstick is sufficient.
Report Delivery
No restrictions. You can resume normal activities immediately.
Timeline: Reports are typically available within 3 to 4 weeks after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify pathogenic variants in the HOXB13 gene that are associated with familial prostate cancer. It helps in risk stratification, guiding screening protocols, and informing family members about their inherited risk. The test is recommended for individuals with a personal or family history of prostate cancer, especially those with early-onset disease or multiple affected relatives.
How to Prepare
- Ensure the sample is collected in the provided EDTA tube or on the FTA card.
- Label the sample with your name and date of birth.
- If using FTA card, allow it to air dry for 30 minutes before placing in the provided envelope.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for HOXB13 is crucial for men with a strong family history of prostate cancer. Early identification allows for enhanced surveillance and preventive strategies."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed blood sample
- Clotted blood sample
- Insufficient sample volume
- Improperly labeled sample
- Sample received after prolonged transit time (>7 days) without proper storage
Understanding Your Results
Positive for pathogenic variant
Increased risk of prostate cancer; recommend enhanced screening (PSA and DRE annually starting at age 40) and consider preventive options.
Negative for pathogenic variant
No increased risk due to HOXB13; however, other genetic and environmental factors may still contribute.
Variant of Uncertain Significance (VUS)
The clinical significance is unknown; additional family testing may help clarify.
Consult your oncologist or genetic counselor if you have a family history of prostate cancer, if you test positive for a HOXB13 mutation, or if you have concerns about your genetic risk.
Limitations
- ⚠This test only analyzes the HOXB13 gene and selected related genes; other genetic causes may not be detected.
- ⚠Variant of uncertain significance (VUS) may be reported; further family studies may be needed.
- ⚠Negative result does not rule out hereditary prostate cancer due to other genes.
- ⚠Raw data analysis requires bioinformatics expertise; clinical interpretation is based on current guidelines.
Risks & Considerations
- ●Minimal risk of bruising or infection at the blood draw site
- ●Psychological impact of learning genetic risk
- ●Potential for incidental findings
Interfering Factors
- ●Contaminated or degraded DNA sample
- ●Recent blood transfusion (within 2 weeks)
- ●Bone marrow transplantation
- ●Clonal hematopoiesis of indeterminate potential (CHIP)
Compare With Similar Tests
| Test | HOXB13 Gene Prostate cancer, familial, association with NGS Genetic Test | BRCA1/BRCA2 Gene Test | Prostate Cancer Gene Panel (Multi-gene) |
|---|---|---|---|
| Comparison | HOXB13 Gene Prostate cancer, familial, association with NGS Genetic Test | BRCA1/2 are also associated with prostate cancer risk, but HOXB13 is more specific for familial prostate cancer. | A multi-gene panel includes HOXB13 and other genes like BRCA1/2, MLH1, etc., providing broader risk assessment. |
Frequently Asked Questions
What is the HOXB13 gene?
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