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Imatinib Resistance Mutation Analysis IRMA Test

DNA Labs India | ISO 9001:2015 Certified

Imatinib Resistance Mutation Analysis IRMA Test

Short Name: IRMA Test

Also known as: IRMA Test, Imatinib Resistance Mutation Analysis

Imatinib Resistance Mutation Analysis IRMA Test test available at DNA Labs India for ₹0. Uses PCR, DNA Sequencing on Whole blood samples. Results in Results typically available within 5-7 working days after sample receipt at the lab.. Free home collection in 300+ cities across India.

Molecular Genetic TestAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The primary purpose of the IRMA test is to identify genetic mutations that confer resistance to Imatinib in patients with CML or GIST. This information helps oncologists make informed decisions about continuing or changing therapy, optimizing treatment efficacy and minimizing unnecessary side effects.

Test Code
855
Sample Type
Whole blood
Result Time
Results typically available within 5-7 working days after sample receipt at the lab.
Fasting Required
No
Method
PCR, DNA Sequencing
Step 1

Sample Collection

Ensure the patient has not received recent blood transfusions. Submit the latest BCR-ABL Quantitative report along with the sample.

Method: Venipuncture

Step 2

Laboratory Analysis

Collect 4 mL of whole blood in an EDTA tube using standard venipuncture techniques.

Step 3

Report Delivery

Label the sample properly and store refrigerated. Do not freeze. Transport to the lab within 48 hours.

Timeline: Results typically available within 5-7 working days after sample receipt at the lab.

Patient Instructions

1
Before the Test:Provide medical history, current medications, and latest BCR-ABL report. No fasting required.
2
During the Test:A blood sample is drawn and sent for genetic analysis using PCR and sequencing methods.
3
After the Test:Results are reviewed by a pathologist and sent to the physician for interpretation and treatment planning.

About This Test

Who Should Get This Test

The primary purpose of the IRMA test is to identify genetic mutations that confer resistance to Imatinib in patients with CML or GIST. This information helps oncologists make informed decisions about continuing or changing therapy, optimizing treatment efficacy and minimizing unnecessary side effects.

How to Prepare

  • Use a Lavender Top (EDTA) tube.
  • Collect minimum 2 mL of blood.
  • Ship refrigerated, do not freeze.
  • Include BCR-ABL Quantitative report with the sample.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"The IRMA test is crucial for guiding treatment decisions in CML and GIST patients showing resistance to Imatinib, helping to switch to alternative therapies and improve outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole blood
Sample Volume4 mL (2 mL min.)
ContainerLavender Top (EDTA) tube
Collection MethodVenipuncture

Sample Stability

Room Temperature
Refrigerated (2-8°C)
Frozen
Sample Rejection Criteria:
  • Hemolyzed or clotted samples.
  • Samples without proper documentation or labeling.
  • Frozen samples or those stored at room temperature for extended periods.

Understanding Your Results

The IRMA test results indicate the presence or absence of mutations associated with Imatinib resistance. A positive result suggests that the cancer cells may not respond effectively to Imatinib, while a negative result indicates susceptibility to the drug.
Positive for mutations: Consider alternative therapies, dose adjustments, or switching to second-line TKIs.
Negative for mutations: Continue with Imatinib therapy as prescribed, with regular monitoring.
Uncertain or mixed results: Repeat testing or additional genetic analysis may be recommended.
Correlate results with clinical symptoms, imaging, and other lab tests for comprehensive assessment.
⚠️ When to Consult a Doctor:

If the test shows positive mutations, or if symptoms such as increased fatigue, weight loss, or enlarged spleen persist or worsen despite Imatinib treatment, consult your oncologist immediately.

Limitations

  • ⚠Test may not detect all possible resistance mutations.
  • ⚠Results should be correlated with clinical findings and other diagnostic tests.
  • ⚠Limited to mutations in the BCR-ABL kinase domain; other resistance mechanisms may not be identified.

Risks & Considerations

  • ●Minimal risks associated with blood draw, such as bruising, soreness, or infection.
  • ●No significant risks from the genetic test itself.

Interfering Factors

  • ●Recent blood transfusions may affect DNA analysis.
  • ●Contaminated or improperly stored samples.
  • ●Use of certain medications that alter DNA stability.

Compare With Similar Tests

TestImatinib Resistance Mutation Analysis IRMA Test
ComparisonImatinib Resistance Mutation Analysis IRMA Test

Frequently Asked Questions

What is the Imatinib Resistance Mutation Analysis (IRMA) Test?
The IRMA test is a genetic test that analyzes DNA from cancer cells to detect mutations in the BCR-ABL kinase domain that may cause resistance to Imatinib, used in CML and GIST treatment.
Who should get the IRMA Test done?
Patients with CML or GIST who are not responding to Imatinib therapy, showing disease progression, or experiencing symptoms like increased fatigue or weight loss.
How is the IRMA Test performed?
The test involves drawing a blood sample, extracting DNA, and using PCR and sequencing to identify specific mutations associated with Imatinib resistance.
What do the IRMA Test results indicate?
A positive result indicates the presence of resistance mutations, suggesting Imatinib may be ineffective. A negative result means no mutations were detected, indicating potential susceptibility.
What is the cost of the IRMA Test at DNA Labs India?
The IRMA test at DNA Labs India is priced at INR 0, with home sample collection available at no additional cost.
Is home sample collection available for the IRMA Test?
Yes, DNA Labs India offers free home sample collection for the IRMA test across many cities in India.
How long does it take to receive IRMA Test results?
Results are typically available within 5-7 working days after the sample reaches the lab.
Are there any risks associated with the IRMA Test?
The test involves a standard blood draw, which may cause minor bruising or soreness. There are no significant risks from the genetic analysis.
What causes Imatinib resistance in cancer treatment?
Imatinib resistance often arises from genetic mutations in the BCR-ABL kinase domain, which reduce the drug's binding efficacy, leading to treatment failure.
Can the IRMA Test be repeated if needed?
Yes, the test can be repeated if initial results are uncertain, or if there are changes in clinical status, to monitor for resistance development.
What are the treatment options if Imatinib resistance is detected?
Options may include switching to second-line tyrosine kinase inhibitors like Dasatinib or Nilotinib, adjusting doses, or exploring clinical trials, based on physician guidance.
Is the IRMA Test covered by health insurance schemes?
Coverage varies; the test is not typically covered under government schemes like PMJAY, but private insurance may cover it partially. Check with your insurer for details.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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