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Immunohistochemistry Glycophorin A (GPA) Test

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Immunohistochemistry Glycophorin A (GPA) Test

Short Name: Glycophorin A (GPA) IHC Test

Also known as: GPA IHC Test, Glycophorin A Immunohistochemistry, IHC for Glycophorin A

Immunohistochemistry Glycophorin A (GPA) Test test available at DNA Labs India for ₹3,500. Uses Immunohistochemistry on Submit tumor tissue in 10% Formal-saline OR Formalin fixed paraffin embedded block. samples. Results in 5-7 days from sample receipt. Free home collection in 300+ cities across India.

Immunohistochemistry🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To identify glycophorin A expression in red blood cells and bone marrow precursors for diagnosing blood disorders, including erythroid malignancies, and for forensic blood analysis.

Test Code
891
Price
₹3,500
Sample Type
Submit tumor tissue in 10% Formal-saline OR Formalin fixed paraffin embedded block.
Result Time
5-7 days from sample receipt
Fasting Required
No
Method
Immunohistochemistry
Step 1

Sample Collection

Ensure clinical history, histopathology report, and site of biopsy are available for submission with the sample.

Method: Biopsy collection

Step 2

Laboratory Analysis

Biopsy tissue is collected and placed in 10% formal-saline or as a formalin-fixed paraffin-embedded block.

Step 3

Report Delivery

Sample is shipped at room temperature to the laboratory for processing.

Timeline: 5-7 days from sample receipt

Patient Instructions

1
Before the Test:Provide necessary documents and samples as per collection instructions.
2
During the Test:Tissue sample undergoes immunohistochemical staining for glycophorin A.
3
After the Test:Results are analyzed by a pathologist and reported via the chosen delivery method.

About This Test

Who Should Get This Test

To identify glycophorin A expression in red blood cells and bone marrow precursors for diagnosing blood disorders, including erythroid malignancies, and for forensic blood analysis.

How to Prepare

  • Provide a copy of the histopathology report
  • Specify the site of biopsy
  • Include clinical history and suspected diagnosis

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"The Immunohistochemistry Glycophorin A (GPA) test is crucial for identifying erythroid lineage in bone marrow and diagnosing specific blood disorders, aiding in accurate treatment planning."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeSubmit tumor tissue in 10% Formal-saline OR Formalin fixed paraffin embedded block.
ContainerFormalin container or paraffin block
Collection MethodBiopsy collection

Sample Stability

Formalin-fixed tissue stable at room temperature for extended periods
Paraffin blocks can be stored at room temperature
Sample Rejection Criteria:
  • Inadequate or degraded tissue sample
  • Missing clinical information or histopathology report

Understanding Your Results

Results are interpreted based on the presence or absence of glycophorin A staining, which indicates erythroid lineage involvement. Positive staining may suggest erythroid malignancies or blood disorders, while negative results may require further testing.
📊

Positive for Glycophorin A

Indicates expression on erythroid cells, consistent with erythroid precursors, mature erythrocytes, or conditions like AML-M6.

📊

Negative for Glycophorin A

Suggests absence of glycophorin A; may require additional tests to rule out other causes.

📊

Focal or Weak Staining

May indicate partial expression or early-stage changes; clinical correlation recommended.

⚠️ When to Consult a Doctor:

If you experience symptoms such as fatigue, weakness, shortness of breath, pale skin, jaundice, easy bruising, or bleeding, consult a healthcare professional for evaluation and possible testing.

Limitations

  • ⚠Requires high-quality tissue samples; inadequate samples may yield inconclusive results
  • ⚠Interpretation dependent on expert pathologist assessment
  • ⚠Not standalone for diagnosis; should be correlated with clinical history and other tests

Risks & Considerations

  • ●Minimal risks associated with biopsy collection, such as minor bleeding or infection
  • ●No direct risks from the immunohistochemistry test itself

Interfering Factors

  • ●Improper tissue fixation or processing
  • ●Sample degradation or contamination
  • ●Use of incorrect staining protocols

Frequently Asked Questions

What is the Immunohistochemistry Glycophorin A (GPA) test?
It is a diagnostic test that uses immunohistochemistry to detect glycophorin A protein on red blood cells and bone marrow precursors, helping identify blood disorders and erythroid malignancies.
Why is this test performed?
It is performed to diagnose conditions like sickle cell anemia, hereditary spherocytosis, AML-M6, and for forensic analysis of blood stains.
How is the test conducted?
A tissue sample, such as a biopsy, is collected and processed using immunohistochemical staining to visualize glycophorin A expression under a microscope.
What sample is required for the test?
Tumor tissue submitted in 10% formal-saline or as a formalin-fixed paraffin-embedded block, along with histopathology report and clinical history.
Is fasting required before the test?
No, fasting is not required for this test.
What is the cost of the Immunohistochemistry Glycophorin A (GPA) test?
The test costs INR 3500.0 at DNA Labs India, inclusive of home collection services.
How long does it take to get the results?
Results are typically available within 5-7 days after sample receipt, with samples collected daily by 6 pm.
What do positive results mean?
Positive results indicate glycophorin A expression, suggesting erythroid lineage involvement, which may be seen in blood disorders or malignancies like AML-M6.
Are there any risks associated with the test?
The risks are minimal and primarily related to the biopsy procedure, such as minor bleeding or infection; the immunohistochemistry test itself is non-invasive.
How accurate is the Immunohistochemistry Glycophorin A (GPA) test?
The test is highly accurate for identifying glycophorin A when performed on quality samples, but results should be interpreted in conjunction with clinical findings.
Can this test diagnose cancer?
Yes, it can help diagnose erythroid malignancies such as AML-M6 by identifying abnormal glycophorin A expression in bone marrow cells.
How do I prepare for the test?
Ensure you have the necessary documents, including histopathology report, site of biopsy, and clinical history. No special preparation is needed for the patient.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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