Immunohistochemistry SATB2 Test
Short Name: SATB2 IHC Test
Also known as: SATB2 Immunostaining, SATB2 Protein Detection Test, Special AT rich sequence binding protein 2 Test
Immunohistochemistry SATB2 Test test available at DNA Labs India for ₹3,500. Uses Immunohistochemistry on Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block samples. Results in Reports available in 5-7 days after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of the Immunohistochemistry SATB2 Test is to detect SATB2 protein expression in tissue cells, aiding in the diagnosis and differentiation of various diseases. It is primarily used to confirm colorectal cancer origin, identify adenocarcinomas of unknown primary, and distinguish between primary ovarian tumors and metastatic colorectal cancer. Additionally, it helps in evaluating conditions like intellectual disability, cleft palate, and osteoporosis where SATB2 abnormalities may be present. The test provides critical information for oncologists and pathologists to guide appropriate treatment strategies.
- Test Code
- 893
- Price
- ₹3,500
- Sample Type
- Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block
- Result Time
- Reports available in 5-7 days after sample receipt.
- Fasting Required
- No
- Method
- Immunohistochemistry
Sample Collection
Provide a copy of the histopathology report, site of biopsy, and clinical history. No fasting required. Ensure proper documentation.
Method: Biopsy or surgical specimen collection
Laboratory Analysis
Tissue sample collected via biopsy or surgical excision under sterile conditions. Sample placed in 10% formal-saline or formalin for preservation.
Report Delivery
Sample transported at room temperature to the laboratory. Post-biopsy care as per healthcare provider instructions.
Timeline: Reports available in 5-7 days after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Immunohistochemistry SATB2 Test is to detect SATB2 protein expression in tissue cells, aiding in the diagnosis and differentiation of various diseases. It is primarily used to confirm colorectal cancer origin, identify adenocarcinomas of unknown primary, and distinguish between primary ovarian tumors and metastatic colorectal cancer. Additionally, it helps in evaluating conditions like intellectual disability, cleft palate, and osteoporosis where SATB2 abnormalities may be present. The test provides critical information for oncologists and pathologists to guide appropriate treatment strategies.
How to Prepare
- Submit tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block
- Ship at room temperature
- Include a copy of the histopathology report, site of biopsy, and clinical history
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"SATB2 is a specific biomarker for colorectal cancer, crucial for identifying tumor origin in adenocarcinomas of unknown primary and distinguishing ovarian mucinous tumors from metastases."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample not in proper fixative
- Missing clinical information or histopathology report
- Inadequate tissue quantity
- Sample contaminated or degraded
Understanding Your Results
Positive for SATB2
Indicates SATB2 protein expression, commonly associated with colorectal cancer origin, useful for confirming adenocarcinomas of unknown primary.
Negative for SATB2
No detectable SATB2 expression, may help rule out colorectal origin, but clinical correlation is essential.
Weak or focal staining
May require further testing or correlation with other biomarkers for definitive diagnosis.
Consult a doctor if you have symptoms suggestive of cancer (e.g., unexplained weight loss, persistent pain), known intellectual disability, cleft palate, or osteoporosis, or if recommended by your healthcare provider for diagnostic evaluation.
Limitations
- ⚠False negatives if SATB2 expression is low or focal
- ⚠False positives due to non-specific staining
- ⚠Requires correlation with clinical history and other tests
- ⚠Not definitive for diagnosis alone; should be part of a comprehensive evaluation
Risks & Considerations
- ●Minimal risks associated with biopsy collection, such as infection or bleeding
- ●No direct risks from the IHC test itself; it is a laboratory procedure
Interfering Factors
- ●Improper tissue fixation
- ●Tissue degradation or necrosis
- ●Inadequate sample size
- ●Technical errors in staining process
Compare With Similar Tests
| Test | Immunohistochemistry SATB2 Test | Immunohistochemistry CDX2 Test | Immunohistochemistry CK20 Test | Biopsy of Tumor | CT Scan or MRI |
|---|---|---|---|---|---|
| Comparison | Immunohistochemistry SATB2 Test | CDX2 is another biomarker for gastrointestinal cancers; SATB2 is more specific for colorectal origin. | CK20 is used for colorectal cancer but less specific than SATB2 for origin identification. | Biopsy provides tissue for multiple tests; SATB2 IHC adds specific protein expression data. | Imaging tests detect tumor location and size, while SATB2 IHC provides molecular-level diagnosis. |
Frequently Asked Questions
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