Immunohistochemistry Synaptophysin Test
Short Name: IHC Synaptophysin Test
Also known as: Synaptophysin IHC, IHC for Synaptophysin, Synaptophysin Immunohistochemistry
Immunohistochemistry Synaptophysin Test test available at DNA Labs India for ₹3,000. Uses Immunohistochemistry on Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block samples. Results in Reports are typically available within 5-7 business days after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
To assist in the diagnosis and typing of neuroendocrine neoplasms by detecting synaptophysin expression in tissue samples.
- Test Code
- 1043
- Price
- ₹3,000
- Sample Type
- Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block
- Result Time
- Reports are typically available within 5-7 business days after sample receipt.
- Fasting Required
- No
- Method
- Immunohistochemistry
Sample Collection
Provide a copy of the histopathology report, site of biopsy, and clinical history.
Method: Tissue biopsy collection
Laboratory Analysis
Tissue biopsy is collected under sterile conditions, fixed in formalin or formal-saline.
Report Delivery
Ship the sample at room temperature to the laboratory.
Timeline: Reports are typically available within 5-7 business days after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
To assist in the diagnosis and typing of neuroendocrine neoplasms by detecting synaptophysin expression in tissue samples.
How to Prepare
- Ensure proper fixation of tissue in 10% formal-saline or formalin.
- Include detailed clinical history and biopsy site information.
- Ship samples at room temperature to avoid degradation.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This test is essential for identifying neuroendocrine neoplasms, which can affect various organs. Early detection through synaptophysin staining helps in planning effective treatment strategies."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Inadequate or improperly fixed tissue
- Missing clinical history or biopsy site details
- Sample contamination
Understanding Your Results
Positive
Indicates presence of synaptophysin, consistent with neuroendocrine differentiation. Further tests may be needed for classification.
Action: Consult an oncologist for diagnosis and treatment planning.
Negative
No detectable synaptophysin expression. Consider other diagnostic tests if clinical suspicion remains.
Action: Review with pathologist and consider additional markers.
If you experience persistent symptoms such as neurological issues, hormonal imbalances, or unexplained weight loss, consult a healthcare provider. Also, consult if test results are abnormal or inconclusive.
Limitations
- ⚠Does not provide information on tumor grade or stage
- ⚠Requires interpretation by a qualified pathologist
- ⚠False positives or negatives may occur in rare cases
Risks & Considerations
- ●For biopsy: risk of infection, bleeding, or discomfort at the biopsy site
- ●For the test itself: no direct risks as it is performed on existing samples
Interfering Factors
- ●Improper tissue fixation
- ●Technical errors in staining
- ●Inadequate tissue sample
- ●Presence of necrotic tissue
Compare With Similar Tests
| Test | Immunohistochemistry Synaptophysin Test | Chromogranin A IHC | Ki-67 IHC | CT Scan or MRI |
|---|---|---|---|---|
| Comparison | Immunohistochemistry Synaptophysin Test | Another neuroendocrine marker; often used alongside synaptophysin for confirmation. | Measures cell proliferation; useful for grading neuroendocrine tumors. | Imaging tests for anatomical localization of tumors. |
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