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Immunohistochemistry Uroplakin-III Test

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Immunohistochemistry Uroplakin-III Test

Short Name: IHC Uroplakin-III

Also known as: IHC Uroplakin-III, Uroplakin-III Immunohistochemistry Test

Immunohistochemistry Uroplakin-III Test test available at DNA Labs India for ₹3,500. Uses Immunohistochemistry on Tumor Tissue samples. Results in Results are typically available within 5-7 days after sample receipt.. Free home collection in 300+ cities across India.

ImmunohistochemistryAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To detect the presence of Uroplakin-III protein in tissue samples for diagnosis and monitoring of bladder cancer.

Test Code
1051
Price
₹3,500
Sample Type
Tumor Tissue
Result Time
Results are typically available within 5-7 days after sample receipt.
Fasting Required
No
Method
Immunohistochemistry
Step 1

Sample Collection

Provide a copy of the Histopathology report, Site of biopsy and Clinical history.

Method: Tissue Biopsy Collection

Step 2

Laboratory Analysis

Tissue biopsy is performed by a qualified healthcare professional.

Step 3

Report Delivery

Sample is sent to the laboratory for immunohistochemical analysis.

Timeline: Results are typically available within 5-7 days after sample receipt.

Patient Instructions

1
Before the Test:Provide a copy of the Histopathology report, Site of biopsy and Clinical history.
2
During the Test:The tissue sample is processed and stained using immunohistochemistry techniques to detect Uroplakin-III protein.
3
After the Test:Results are analyzed and interpreted by a qualified pathologist, and a detailed report is generated.

About This Test

Who Should Get This Test

To detect the presence of Uroplakin-III protein in tissue samples for diagnosis and monitoring of bladder cancer.

How to Prepare

  • Submit tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block.
  • Ship the sample at room temperature.
  • Provide a copy of the Histopathology report, Site of biopsy and Clinical history.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeTumor Tissue
Container10% Formal-saline or Formalin fixed paraffin embedded block
Collection MethodTissue Biopsy Collection

Sample Stability

Room Temperature24 hours
Refrigerated72 hours
Sample Rejection Criteria:
  • Insufficient tissue sample
  • Improperly fixed or preserved sample
  • Missing clinical history or biopsy site information
  • Contaminated or degraded tissue

Understanding Your Results

The interpretation of the Immunohistochemistry Uroplakin-III Test involves examining the tissue sample for the presence of Uroplakin-III protein. A positive result may indicate bladder cancer, while a negative result suggests no detectable expression. Results should be correlated with clinical and histopathological findings.
📊

Positive

Indicates presence of Uroplakin-III protein, which is suggestive of bladder cancer or urothelial carcinoma.

Action: Consult an oncologist for further evaluation, staging, and treatment planning.

📊

Negative

No detectable Uroplakin-III expression in the tissue sample.

Action: Correlate with clinical findings and consider repeat testing if clinical suspicion remains high.

⚠️ When to Consult a Doctor:

If you experience symptoms such as blood in urine, frequent urination, painful urination, back pain, weight loss, or loss of appetite, consult a doctor immediately. If the test result is positive or equivocal, follow up with an oncologist for comprehensive management.

Limitations

  • ⚠Not a standalone diagnostic; must be correlated with histopathological findings
  • ⚠May not detect early-stage or low-grade cancers
  • ⚠Results are dependent on sample quality and laboratory expertise
  • ⚠False negatives or positives can occur; clinical context is essential

Risks & Considerations

  • ●Risk associated with the biopsy procedure, such as bleeding or infection
  • ●Minimal risk from the test itself as it is a laboratory analysis

Interfering Factors

  • ●Inadequate tissue sample quantity or quality
  • ●Improper fixation or preservation of tissue
  • ●Technical errors in staining or processing
  • ●Contamination or degradation of sample

Frequently Asked Questions

What is the Immunohistochemistry Uroplakin-III Test?
It is a diagnostic test that uses immunohistochemistry to detect Uroplakin-III protein in tissue samples, aiding in the diagnosis of bladder cancer.
Why is this test recommended?
It is recommended when bladder cancer is suspected based on symptoms or imaging, or for monitoring known bladder cancer cases.
What is the cost of the test in India?
The cost is INR 3500 at DNA Labs India, with potential discounts for online bookings.
How is the sample collected for this test?
A tissue biopsy is collected and submitted in formal-saline or as a formalin-fixed paraffin block, shipped at room temperature.
What does a positive result mean?
A positive result indicates the presence of Uroplakin-III protein, which is suggestive of bladder cancer or urothelial carcinoma.
What are the common symptoms of bladder cancer?
Symptoms include blood in urine, frequent urination, painful urination, back pain, weight loss, and loss of appetite.
How accurate is the Immunohistochemistry Uroplakin-III Test?
It is a reliable test when performed correctly, but results must be interpreted alongside histopathological and clinical findings.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities across India.
How long does it take to get the test results?
Results are typically available within 5-7 days after sample receipt.
Is the test covered by health insurance?
It may be covered by some insurance plans; it is advisable to check with your provider for coverage details.
What should I do before the test?
Provide a copy of the histopathology report, site of biopsy, and clinical history as instructed.
Who should consider taking this test?
Individuals with symptoms of bladder cancer, those with abnormal bladder findings, or patients undergoing bladder cancer monitoring should consider this test.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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