Immunophenotyping by Flow Cytometry: Leukemia / Lymphoma Diagnostic Panel-Chronic Lymphoproliferative Disorders T & B Cell Test
Short Name: Flow Cytometry: CLPD T & B Cell Panel
Also known as: Flow Cytometry Immunophenotyping for CLPD, Leukemia/Lymphoma Diagnostic Panel, T & B Cell Chronic Lymphoproliferative Disorder Panel
Immunophenotyping by Flow Cytometry: Leukemia / Lymphoma Diagnostic Panel-Chronic Lymphoproliferative Disorders T & B Cell Test test available at DNA Labs India for ₹20,000. Uses Flow Cytometry, Immunophenotyping on 3 mL (2 mL min.) whole blood each in 1 Lavender Top (EDTA) tube AND 1 Green Top (Sodium Heparin) tube OR 2 mL (1 mL min.) Bone marrow in 1 Green Top (Sodium heparin) tube AND Aspirate Smear. samples. Results in Samples are accepted daily by 9 am; reports are delivered the same day. Complex or bone marrow samples may require additional clinical integration and may be communicated by the pathologist.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The test evaluates cell surface markers to aid in the diagnosis and characterisation of neoplasms of hematopoietic origin. Results are useful in the differential diagnosis, therapeutic monitoring, and detection of relapses of these neoplasms.
- Test Code
- 3504
- Price
- ₹20,000
- Sample Type
- 3 mL (2 mL min.) whole blood each in 1 Lavender Top (EDTA) tube AND 1 Green Top (Sodium Heparin) tube OR 2 mL (1 mL min.) Bone marrow in 1 Green Top (Sodium heparin) tube AND Aspirate Smear.
- Result Time
- Samples are accepted daily by 9 am; reports are delivered the same day. Complex or bone marrow samples may require additional clinical integration and may be communicated by the pathologist.
- Fasting Required
- No
- Method
- Flow Cytometry, Immunophenotyping
Sample Collection
Specify time, date, and clinical details on the test request form. No fasting is required. Inform the laboratory if the patient has received recent chemotherapy, immunotherapy, or steroids, as these may affect results.
Method: Venipuncture or Bone Marrow Aspiration
Laboratory Analysis
Whole blood is collected by venipuncture in one Lavender Top (EDTA) tube and one Green Top (Sodium Heparin) tube. Bone marrow samples, when indicated, are collected by a clinician in a Green Top (Sodium Heparin) tube with a separate aspirate smear. Samples must be maintained at 18–22°C.
Report Delivery
Keep samples at room temperature 18–22°C. Do not refrigerate or freeze. Transport immediately to the laboratory to preserve cell viability. Reports are delivered the same day when sample reaches the lab by 9 am.
Timeline: Samples are accepted daily by 9 am; reports are delivered the same day. Complex or bone marrow samples may require additional clinical integration and may be communicated by the pathologist.
Patient Instructions
About This Test
Who Should Get This Test
The test evaluates cell surface markers to aid in the diagnosis and characterisation of neoplasms of hematopoietic origin. Results are useful in the differential diagnosis, therapeutic monitoring, and detection of relapses of these neoplasms.
How to Prepare
- Collect 3 mL whole blood in each Lavender Top (EDTA) and Green Top (Sodium Heparin) tube OR 2 mL bone marrow in Green Top (Sodium Heparin) tube and aspirate smear
- Label all tubes with patient details, date, and time of collection
- Do not refrigerate or freeze; maintain samples at 18–22°C
- Ship immediately to the laboratory
- Include clinical details and provisional diagnosis on the test request form
- For bone marrow, send aspirate smear along with heparinized sample
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Flow cytometry immunophenotyping is essential for lineage assignment and subclassification of chronic lymphoproliferative disorders. Results should always be integrated with morphology, clinical features, and molecular or cytogenetic studies before final diagnosis and treatment planning."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Refrigerated or frozen samples
- Clotted or hemolysed specimens
- Incorrect anticoagulant or tube type
- Insufficient sample volume
- Missing clinical details or unlabeled tube
- Delay in transport beyond room temperature stability
Understanding Your Results
No abnormal lymphoid population detected
Normal immunophenotype; no evidence of a clonal B-cell or aberrant T-cell population.
Monotypic B-cell population detected
Suggests a B-cell chronic lymphoproliferative disorder. The antigen profile helps classify the subtype and must be correlated with clinical, morphological, and molecular findings.
Aberrant T-cell population detected
May indicate a T-cell chronic lymphoproliferative disorder. Correlation with T-cell receptor gene rearrangement and clinical features is required.
Increased blasts or atypical cells
May indicate a more aggressive leukemia/lymphoma and requires urgent oncology review and additional investigations.
Consult an oncologist or hematologist if you have unexplained fatigue, weight loss, fever, night sweats, enlarged lymph nodes or spleen, recurrent infections, or abnormal blood counts. A positive or indeterminate flow cytometry result requires specialist correlation for accurate diagnosis and treatment planning.
Limitations
- ⚠Flow cytometry immunophenotyping should be interpreted with morphology, clinical features, and genetic or molecular studies
- ⚠A non-diagnostic immunophenotype does not completely exclude a lymphoproliferative disorder
- ⚠Small sample volume or low cell viability may limit comprehensive marker analysis
- ⚠Rare or atypical lymphoid neoplasms may require extended panels or molecular studies
- ⚠The panel does not independently provide chromosomal or molecular prognostic information
Risks & Considerations
- ●Venipuncture may cause mild pain, bruising, or dizziness
- ●Bone marrow aspiration carries a small risk of bleeding, pain, infection, or local discomfort
- ●Bone marrow aspiration is performed only by a qualified clinician
Interfering Factors
- ●Recent chemotherapy, immunotherapy, or steroids may alter lymphocyte marker expression and reduce abnormal cell numbers
- ●Improper sample storage, refrigeration, or freezing can reduce cell viability and affect marker detection
- ●Clotted or hemolysed samples may yield unreliable flow cytometry results
- ●Delay in transport beyond room temperature stability may impair analysis
- ●Recent infection or acute illness may cause reactive lymphoid changes
Compare With Similar Tests
| Test | Immunophenotyping by Flow Cytometry: Leukemia / Lymphoma Diagnostic Panel-Chronic Lymphoproliferative Disorders T & B Cell Test | ||||
|---|---|---|---|---|---|
| Comparison | Immunophenotyping by Flow Cytometry: Leukemia / Lymphoma Diagnostic Panel-Chronic Lymphoproliferative Disorders T & B Cell Test |
Frequently Asked Questions
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