Inv16 (p13q22) / t(1616)(p13q22) Gene Rearrangement Qualitative PCR Test
Also known as: Inv16 PCR Test, t(16;16) PCR Test, Inv16 Gene Rearrangement Test
Inv16 (p13q22) / t(1616)(p13q22) Gene Rearrangement Qualitative PCR Test test available at DNA Labs India for ₹6,000. Uses Real Time PCR on Whole blood or Bone Marrow samples. Results in Sample accepted on Monday or Thursday by 11 am; reports delivered by Wednesday or Saturday.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The primary purpose of the Inv16 gene rearrangement qualitative PCR test is to detect the presence of specific genetic mutations or rearrangements involving chromosome 16, which are hallmark indicators of certain hematological malignancies, including acute myeloid leukemia. This test aids in confirming diagnoses, evaluating treatment response, and monitoring minimal residual disease, thereby playing a critical role in patient management and therapeutic decision-making.
- Test Code
- 1122
- Price
- ₹6,000
- Sample Type
- Whole blood or Bone Marrow
- Result Time
- Sample accepted on Monday or Thursday by 11 am; reports delivered by Wednesday or Saturday.
- Fasting Required
- No
- Method
- Real Time PCR
Sample Collection
Ensure the Genomics Clinical Information Requisition Form (Form 20) is duly filled. No fasting required, but inform the healthcare provider about any medications or recent treatments.
Method: Venipuncture for blood, Bone Marrow Aspiration for bone marrow
Laboratory Analysis
Blood sample collected via venipuncture into an EDTA tube; bone marrow aspirated by a trained specialist. The process involves minimal discomfort similar to a standard blood draw.
Report Delivery
Apply pressure to the collection site to prevent bruising. Resume normal activities unless otherwise advised. The sample will be shipped refrigerated for analysis.
Timeline: Sample accepted on Monday or Thursday by 11 am; reports delivered by Wednesday or Saturday.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the Inv16 gene rearrangement qualitative PCR test is to detect the presence of specific genetic mutations or rearrangements involving chromosome 16, which are hallmark indicators of certain hematological malignancies, including acute myeloid leukemia. This test aids in confirming diagnoses, evaluating treatment response, and monitoring minimal residual disease, thereby playing a critical role in patient management and therapeutic decision-making.
How to Prepare
- Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory
- Ship refrigerated; do not freeze the sample
- Use a Lavender Top (EDTA) tube for whole blood collection
- For bone marrow, ensure proper aspiration technique to avoid contamination
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This qualitative PCR test is crucial for detecting Inv16 gene rearrangement, a diagnostic marker in acute myeloid leukemia that influences treatment strategies and prognosis."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Missing or incomplete Genomics Clinical Information Requisition Form
- Improper sample container (non-EDTA tube)
- Sample received frozen or at incorrect temperature
- Insufficient sample volume
Understanding Your Results
Positive
Detection of Inv16 gene rearrangement, which is strongly associated with acute myeloid leukemia and other hematological malignancies. Further clinical evaluation and treatment planning are recommended.
Negative
No Inv16 gene rearrangement detected. This may indicate absence of the specific mutation, but clinical correlation with other tests is advised if symptoms persist.
Consult a hematologist or oncologist immediately if the test result is positive, or if symptoms such as persistent fatigue, weight loss, or abnormal blood counts worsen, for comprehensive diagnosis and management.
Limitations
- ⚠May not detect all variants or subtypes of Inv16 rearrangements
- ⚠Requires adequate sample quality and volume
- ⚠Results should be correlated with clinical findings and other diagnostic tests
Risks & Considerations
- ●Minimal risk from blood draw, such as slight pain, bruising, or infection at the collection site
- ●Rare allergic reactions to antiseptics used during collection
Interfering Factors
- ●Contaminated or degraded DNA samples
- ●Improper sample storage or transport
- ●Presence of inhibitors in the sample affecting PCR amplification
Compare With Similar Tests
| Test | Inv16 (p13q22) / t(1616)(p13q22) Gene Rearrangement Qualitative PCR Test | Fluorescence In Situ Hybridization (FISH) for Inv16 | Cytogenetic Analysis |
|---|---|---|---|
| Comparison | Inv16 (p13q22) / t(1616)(p13q22) Gene Rearrangement Qualitative PCR Test | PCR is more sensitive for detecting minimal residual disease, while FISH provides visual confirmation of chromosomal abnormalities. | PCR offers faster turnaround and higher sensitivity for specific rearrangements, whereas cytogenetic analysis provides a broader view of chromosomal abnormalities. |
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