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Irnotecan Toxicity Assessment (UGT1A1 Genotyping)/ Gilbert Syndrome Test

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Irnotecan Toxicity Assessment (UGT1A1 Genotyping)/ Gilbert Syndrome Test

Short Name: UGT1A1 Genotyping

Also known as: UGT1A1 Genotyping, Gilbert Syndrome Test, Irinotecan Toxicity Test

Irnotecan Toxicity Assessment (UGT1A1 Genotyping)/ Gilbert Syndrome Test test available at DNA Labs India for ₹7,500. Uses Sanger Sequencing on Peripheral Blood samples. Results in 7-8 days. Free home collection in 300+ cities across India.

Gynecologist🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To assess the risk of irnotecan toxicity in patients undergoing chemotherapy and to identify individuals with Gilbert Syndrome who may be at increased risk, guiding personalized treatment decisions.

Test Code
3056
Price
₹7,500
Sample Type
Peripheral Blood
Result Time
7-8 days
Fasting Required
No
Method
Sanger Sequencing
Step 1

Sample Collection

A doctor's prescription is required. Inform the healthcare provider about any medications, supplements, or medical conditions. No specific fasting is required unless advised by the physician.

Method: Venipuncture

Step 2

Laboratory Analysis

A standard blood draw will be performed by a trained phlebotomist. The process involves cleaning the site, inserting a needle into a vein, and collecting blood into an EDTA vacutainer.

Step 3

Report Delivery

Apply pressure to the puncture site with a cotton ball to stop bleeding. A bandage may be applied. Resume normal activities unless otherwise directed.

Timeline: 7-8 days

Patient Instructions

1
Before the Test:Consult with an oncologist to obtain a prescription and discuss the need for UGT1A1 genotyping based on treatment plans.
2
During the Test:A blood sample will be collected via venipuncture. The procedure is quick and minimally invasive.
3
After the Test:Wait for the report, which will be delivered in 7-8 days. Discuss the results with your doctor to adjust treatment if necessary.

About This Test

Who Should Get This Test

To assess the risk of irnotecan toxicity in patients undergoing chemotherapy and to identify individuals with Gilbert Syndrome who may be at increased risk, guiding personalized treatment decisions.

How to Prepare

  • Bring a valid doctor's prescription and identification
  • Wear loose clothing for easy access to the arm
  • Stay hydrated before the test
  • Inform the collector about any allergies or phobias

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"UGT1A1 genotyping helps in personalizing irnotecan chemotherapy to minimize toxicity risks, especially in patients with Gilbert Syndrome."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypePeripheral Blood
Sample Volume2 ml
ContainerEDTA Vacutainer
Collection MethodVenipuncture

Sample Stability

Blood sample stable at 2-8°C for up to 48 hours
Avoid freezing the sample
Sample Rejection Criteria:
  • Insufficient sample volume
  • Incorrect sample container
  • Hemolyzed or clotted samples
  • Unlabeled or mislabeled samples

Understanding Your Results

The test results indicate the genotype of the UGT1A1 gene, which influences the metabolism of irnotecan. Variations in this gene can affect drug efficacy and toxicity risk.
📊

Standard metabolism of irnotecan. Usual dosing is appropriate with regular monitoring.

📊

Reduced metabolism of irnotecan. Consider dose reduction or increased monitoring for toxicity.

📊

Significantly reduced metabolism, high risk of severe toxicity. Alternative chemotherapy or substantial dose reduction is recommended.

⚠️ When to Consult a Doctor:

Consult a doctor if experiencing severe side effects during irnotecan therapy, such as persistent diarrhea, fever, or signs of infection, or if test results indicate a high-risk genotype.

Limitations

  • ⚠Does not detect all possible UGT1A1 gene variants
  • ⚠Results must be interpreted in conjunction with clinical history and other tests
  • ⚠Limited to specific genetic variations related to irnotecan metabolism

Risks & Considerations

  • ●Minor bruising or pain at the puncture site
  • ●Rare risk of infection or fainting
  • ●No significant long-term risks

Interfering Factors

  • ●Hemolyzed blood samples
  • ●Recent blood transfusions
  • ●Contaminated samples

Frequently Asked Questions

What is UGT1A1 genotyping?
UGT1A1 genotyping is a blood test that identifies variations in the UGT1A1 gene, which affects the metabolism of drugs like irnotecan and is linked to Gilbert Syndrome.
Why is this test important for irnotecan therapy?
It helps assess the risk of severe toxicity from irnotecan, allowing doctors to personalize dosing or choose alternative treatments to improve safety and efficacy.
What is Gilbert Syndrome?
Gilbert Syndrome is a benign genetic condition where the liver has reduced ability to process bilirubin, leading to mild jaundice. It increases the risk of irnotecan toxicity.
How is the test performed?
A small blood sample is drawn from a vein in your arm and sent to the lab for analysis using Sanger sequencing to detect UGT1A1 gene variants.
What are the symptoms of irnotecan toxicity?
Symptoms include nausea, vomiting, diarrhea, fever, chills, decreased white blood cell and platelet counts, increased liver enzymes, and jaundice.
How long does it take to get results?
Results are typically available within 7-8 days after sample collection.
What is the cost of the test?
The cost is INR 7500, which includes home sample collection across India.
Is home collection available?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities across India.
What should I do before the test?
You need a doctor's prescription. No fasting is required unless specified. Inform the lab about any medications or health conditions.
How are results interpreted?
Results show your UGT1A1 genotype: normal (6/6), intermediate (6/7), or at-risk (7/7). Your doctor will use this to guide treatment decisions.
Can this test be done for children?
Yes, the test can be performed on individuals of all ages, but it should be ordered by a healthcare provider based on clinical need.
What if my results show a high-risk genotype?
If you have a high-risk genotype (e.g., 7/7), your doctor may recommend a lower dose of irnotecan or an alternative chemotherapy to avoid severe toxicity.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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