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DNA Labs India

KCNE1 Gene Jervell and Lange-Nielsen syndrome type 2 NGS Genetic Test

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KCNE1 Gene Jervell and Lange-Nielsen syndrome type 2 NGS Genetic Test

Also known as: Jervell and Lange-Nielsen Syndrome Type 2, JLNS Type 2, KCNE1-related Long QT Syndrome

KCNE1 Gene Jervell and Lange-Nielsen syndrome type 2 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Next Generation Sequencing (NGS) Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of the KCNE1 Gene NGS Genetic Test is to identify mutations in the KCNE1 gene associated with Jervell and Lange-Nielsen Syndrome Type 2, enabling accurate diagnosis, risk assessment, and informed management of cardiac and hearing-related symptoms.

Test Code
5260
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

Clinical history of the patient and a genetic counseling session to draw a pedigree chart of family members affected with Jervell and Lange-Nielsen Syndrome Type 2.

Method: Blood draw or FTA card collection

Step 2

Laboratory Analysis

Sample collection via blood draw or FTA card, performed by a trained phlebotomist.

Step 3

Report Delivery

Sample is processed and analyzed using NGS technology in the laboratory.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history assessment are recommended before testing.
2
During the Test:Sample collection is a standard blood draw or FTA card procedure.
3
After the Test:Results are available in 3 to 4 weeks; follow-up with a healthcare provider for interpretation.

About This Test

Who Should Get This Test

The purpose of the KCNE1 Gene NGS Genetic Test is to identify mutations in the KCNE1 gene associated with Jervell and Lange-Nielsen Syndrome Type 2, enabling accurate diagnosis, risk assessment, and informed management of cardiac and hearing-related symptoms.

How to Prepare

  • Provide a blood sample or use an FTA card for DNA collection.
  • Ensure proper labeling and handling of the sample.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Early genetic testing for KCNE1 mutations can help in managing Jervell and Lange-Nielsen Syndrome Type 2, preventing cardiac complications and hearing loss."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodBlood draw or FTA card collection

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the KCNE1 gene. A positive result confirms a genetic predisposition to Jervell and Lange-Nielsen Syndrome Type 2, while a negative result suggests no detected mutations, but does not rule out other genetic causes.
📊

Positive for pathogenic variant

Confirms diagnosis of Jervell and Lange-Nielsen Syndrome Type 2; genetic counseling and cardiac monitoring recommended.

📊

Negative for pathogenic variant

No mutations detected in KCNE1 gene; consider other genetic tests if symptoms persist.

📊

Variant of uncertain significance

Further testing and clinical evaluation needed; genetic counseling advised.

⚠️ When to Consult a Doctor:

Consult a healthcare provider or genetic counselor if experiencing symptoms such as irregular heartbeats, fainting, hearing loss, or if there is a family history of Jervell and Lange-Nielsen Syndrome Type 2.

Limitations

  • ⚠Not all mutations in the KCNE1 gene are associated with Jervell and Lange-Nielsen Syndrome Type 2; clinical correlation is essential.

Risks & Considerations

  • ●Minor bruising at the blood draw site
  • ●Rare risk of infection

Frequently Asked Questions

What is Jervell and Lange-Nielsen Syndrome Type 2?
It is a rare genetic disorder that affects the heart's electrical activity and causes hearing loss, caused by mutations in the KCNE1 gene.
What causes Jervell and Lange-Nielsen Syndrome Type 2?
It is caused by mutations in the KCNE1 gene, inherited in an autosomal recessive pattern, requiring two defective gene copies from both parents.
What are the symptoms of Jervell and Lange-Nielsen Syndrome Type 2?
Common symptoms include irregular heartbeats, fainting spells, hearing loss, dizziness, shortness of breath, chest pain, and palpitations.
How is Jervell and Lange-Nielsen Syndrome Type 2 diagnosed?
Diagnosis is through genetic testing, specifically NGS sequencing of the KCNE1 gene to identify mutations.
What is the KCNE1 Gene NGS Genetic Test?
It is a Next Generation Sequencing test that analyzes the KCNE1 gene for mutations associated with Jervell and Lange-Nielsen Syndrome Type 2.
How much does the KCNE1 Gene NGS Genetic Test cost in India?
The cost is INR 20,000 at DNA Labs India, with free home sample collection available.
What sample is required for the test?
The test requires a blood sample, extracted DNA, or one drop of blood on an FTA card.
Is fasting required for the test?
No, fasting is not required for this genetic test.
How long does it take to get the test results?
Results are typically available in 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across India.
Who should consider getting tested for Jervell and Lange-Nielsen Syndrome Type 2?
Individuals with symptoms like irregular heartbeats or hearing loss, or those with a family history of the syndrome, should consider testing.
What are the risks associated with the test?
The test involves minimal risks, such as minor bruising from blood draw, with no significant health risks.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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