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KCNE3 Gene Brugada syndrome type 6 NGS Genetic Test

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KCNE3 Gene Brugada syndrome type 6 NGS Genetic Test

Short Name: KCNE3 Brugada Type 6 Test

Also known as: Brugada Syndrome Type 6 Genetic Test, KCNE3 Gene Mutation Analysis

KCNE3 Gene Brugada syndrome type 6 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify mutations in the KCNE3 gene associated with Brugada Syndrome Type 6, enabling early diagnosis, risk assessment, and informed treatment decisions to prevent sudden cardiac arrest.

Test Code
5191
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Provide clinical history and undergo genetic counselling to draw a pedigree chart of affected family members.

Method: Blood draw or saliva collection

Step 2

Laboratory Analysis

Sample collected via blood draw from a vein or saliva swab, performed by a trained phlebotomist.

Step 3

Report Delivery

Sample is labeled, stored, and transported to the laboratory for analysis.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counselling session to discuss family history and test implications. Provide informed consent.
2
During the Test:Non-invasive sample collection (blood or saliva) takes about 10-15 minutes.
3
After the Test:Wait for results (3-4 weeks). Schedule a follow-up with your doctor to discuss findings and next steps.

About This Test

Who Should Get This Test

The purpose of this test is to identify mutations in the KCNE3 gene associated with Brugada Syndrome Type 6, enabling early diagnosis, risk assessment, and informed treatment decisions to prevent sudden cardiac arrest.

How to Prepare

  • Fast for not required, but follow any specific instructions from the lab.
  • Bring identification and prescription if available.
  • Inform the collector about any medications or health conditions.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Early genetic testing for KCNE3 mutations is crucial for managing Brugada Syndrome and preventing sudden cardiac events."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodBlood draw or saliva collection
Sample Rejection Criteria:
  • Hemolyzed or contaminated samples
  • Incorrect labeling
  • Insufficient sample volume

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the KCNE3 gene. Positive results confirm a genetic predisposition to Brugada Syndrome Type 6.
📊

Positive

Pathogenic KCNE3 mutation detected. Increased risk for Brugada Syndrome. Consult a cardiologist for management.

📊

Negative

No pathogenic mutations found. Does not completely rule out Brugada Syndrome if clinical suspicion remains.

📊

Variant of Uncertain Significance

Genetic variant identified but clinical significance unknown. Further testing and monitoring may be recommended.

⚠️ When to Consult a Doctor:

If you experience symptoms like fainting, palpitations, chest pain, or have a family history of Brugada Syndrome or sudden cardiac death, consult a cardiologist or genetic specialist immediately.

Limitations

  • ⚠May not detect all possible genetic variants
  • ⚠Results require clinical correlation
  • ⚠Does not rule out other genetic causes of Brugada Syndrome

Risks & Considerations

  • ●Minor bruising or discomfort at blood draw site
  • ●Very low risk of infection
  • ●Emotional impact of genetic results

Interfering Factors

  • ●Poor sample quality or contamination
  • ●Insufficient DNA quantity
  • ●Technical errors in sequencing

Frequently Asked Questions

What is KCNE3 Gene Brugada Syndrome Type 6?
It is a rare genetic disorder caused by mutations in the KCNE3 gene, leading to abnormal heart electrical activity and increased risk of sudden cardiac arrest.
Who should consider this genetic test?
Individuals with symptoms like fainting, palpitations, chest pain, or a family history of Brugada Syndrome or sudden cardiac death.
How is the test performed?
A blood or saliva sample is collected and analyzed using NGS technology to detect KCNE3 gene mutations.
What is the cost of the test?
The test costs INR 20,000, which includes sample collection, lab analysis, and result interpretation.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection across many cities in India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is the test covered by insurance?
Yes, most health insurance plans cover this test. Check with your provider for specific details.
What do the results mean?
Results indicate if pathogenic KCNE3 mutations are present, helping assess risk and guide treatment. Consult a doctor for interpretation.
Are there any risks associated with the test?
Risks are minimal, such as minor bruising from blood draw. Genetic results may have emotional implications.
Can this test diagnose Brugada Syndrome definitively?
It confirms genetic predisposition but should be used alongside clinical evaluation and other tests like ECG for diagnosis.
What should I do before the test?
Undergo genetic counselling, provide clinical history, and ensure informed consent. No fasting is required.
How accurate is the NGS genetic test?
NGS technology is highly accurate for detecting known mutations, but may not identify all variants. Results are interpreted by experts.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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