KRAS Gene Leukemia, acute myelogenous NGS Genetic Test
Short Name: KRAS AML NGS
Also known as: KRAS Mutation Analysis, KRAS Gene Sequencing, AML NGS Panel
KRAS Gene Leukemia, acute myelogenous NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are typically delivered within 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of this NGS genetic test is to detect mutations in the KRAS gene that are associated with acute myelogenous leukemia (AML). This information aids in confirming diagnosis, assessing prognosis, and guiding personalized treatment strategies, including targeted therapies and clinical trial options.
- Test Code
- 5997
- CPT Code
- 81445
- ICD Code
- C92.00
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are typically delivered within 3 to 4 weeks after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation required. However, a clinical history and genetic counseling session are recommended before the test.
Method: Venipuncture or Fingerstick
Laboratory Analysis
Blood sample will be collected by a trained phlebotomist. If using FTA card, a fingerstick blood drop will be placed on the card.
Report Delivery
No restrictions. You can resume normal activities immediately.
Timeline: Reports are typically delivered within 3 to 4 weeks after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this NGS genetic test is to detect mutations in the KRAS gene that are associated with acute myelogenous leukemia (AML). This information aids in confirming diagnosis, assessing prognosis, and guiding personalized treatment strategies, including targeted therapies and clinical trial options.
How to Prepare
- Ensure the sample is collected in the provided EDTA tube or on the FTA card.
- For FTA card, allow the blood spot to air dry for at least 30 minutes before sealing.
- Label the sample with patient's name, date, and time of collection.
- Transport the sample to the lab at ambient temperature.
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"KRAS mutations in AML are associated with poor prognosis and may influence treatment decisions. NGS testing provides comprehensive mutation profiling, guiding targeted therapy and clinical trial eligibility."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Improperly labeled sample
- Sample received after prolonged transit time (>72 hours) without refrigeration
Understanding Your Results
Negative
No KRAS mutations detected. This suggests that KRAS is not a driver of the leukemia, and other genetic alterations may be involved.
Positive (e.g., G12D, G12V, G13D)
A pathogenic KRAS mutation is present. This may be associated with aggressive disease and poor prognosis. Targeted therapies or clinical trials may be considered.
Variant of Unknown Significance (VUS)
A genetic variant was found, but its clinical significance is not yet established. Further testing or family studies may be needed.
If you experience symptoms such as persistent fatigue, unexplained fever, frequent infections, easy bruising or bleeding, bone pain, or unexplained weight loss, consult a physician immediately. Early diagnosis and treatment of leukemia are critical.
Limitations
- ⚠NGS may not detect all types of KRAS mutations (e.g., large deletions)
- ⚠Low-level mutations may be missed if variant allele frequency is below detection limit
- ⚠Results should be interpreted in conjunction with clinical and pathological findings
- ⚠Not a screening test for healthy individuals
Risks & Considerations
- ●Minimal risk of bruising or infection at the blood draw site
- ●Psychological impact of learning genetic mutation status
- ●Potential for incidental findings unrelated to the current condition
Interfering Factors
- ●Insufficient DNA quantity or quality
- ●Contamination during sample collection
- ●Recent blood transfusion (may dilute patient's cells)
- ●Clonal hematopoiesis of indeterminate potential (CHIP) in older patients
Compare With Similar Tests
| Test | KRAS Gene Leukemia, acute myelogenous NGS Genetic Test | Sanger Sequencing | PCR-based Assays | NGS (This Test) |
|---|---|---|---|---|
| Comparison | KRAS Gene Leukemia, acute myelogenous NGS Genetic Test |
Frequently Asked Questions
What is the cost of the KRAS Gene Leukemia NGS Genetic Test?
What sample is required for this test?
Do I need to fast before the test?
How long does it take to get results?
What is the purpose of this test?
Is home sample collection available?
Will I receive raw data files?
What does a positive KRAS mutation result mean?
Are there any risks associated with the test?
Can this test be done for children?
Is genetic counseling included?
Which cities are covered for home collection?
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Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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