Maternal Serum Screen 2 Dual Test
Short Name: MSS2 Dual Test
Also known as: MSS2 Test, Dual Marker Test, Prenatal Serum Screen
Maternal Serum Screen 2 Dual Test test available at DNA Labs India for ₹2,516. Uses Chemiluminescent Immunoassay on 3 mL serum from 1 SST samples. Results in Same day report delivery for samples received by 9 am Monday to Saturday.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To evaluate the risk of Down syndrome and other chromosomal abnormalities by measuring AFP and free beta-hCG levels in maternal serum for early prenatal risk assessment.
- Test Code
- 1217
- Price
- ₹2,516
- Sample Type
- 3 mL serum from 1 SST
- Result Time
- Same day report delivery for samples received by 9 am Monday to Saturday.
- Fasting Required
- No
- Method
- Chemiluminescent Immunoassay
Sample Collection
Ensure all required maternal information is gathered, including date of birth, LMP or ultrasound date, number of fetuses, diabetic status, body weight, IVF status, smoking history, and previous history of Trisomy 21 pregnancy. Complete the Maternal Serum Screen requisition form (Form 11).
Method: Venipuncture
Laboratory Analysis
A healthcare professional will draw approximately 3 mL of blood from a vein in your arm using standard venipuncture procedure.
Report Delivery
Apply gentle pressure to the puncture site with a cotton ball to stop bleeding. A bandage may be applied. No special aftercare is needed.
Timeline: Same day report delivery for samples received by 9 am Monday to Saturday.
Patient Instructions
About This Test
Who Should Get This Test
To evaluate the risk of Down syndrome and other chromosomal abnormalities by measuring AFP and free beta-hCG levels in maternal serum for early prenatal risk assessment.
How to Prepare
- Provide maternal date of birth in dd/mm/yy format
- Supply last menstrual period (LMP) date or ultrasound dating
- Specify number of fetuses (single or twins)
- Inform diabetic status
- Provide body weight in kilograms
- Disclose IVF status
- State smoking history
- Report any previous history of Trisomy 21 pregnancy
- Submit duly filled Maternal Serum Screen requisition form (Form 11)
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This non-invasive screening test is essential for early risk assessment of chromosomal abnormalities, helping expectant parents make informed decisions about their pregnancy."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample volume less than 1.5 mL
- Use of incorrect sample container
- Missing or incomplete requisition form
- Hemolyzed or lipemic sample
Understanding Your Results
Low Risk
Risk is below the cutoff; further testing usually not recommended, but continue standard prenatal care
Intermediate Risk
Risk is borderline; additional testing may be suggested, such as detailed ultrasound or non-invasive prenatal testing
High Risk
Risk is elevated; diagnostic testing like amniocentesis or chorionic villus sampling is advised to confirm
If your test results indicate intermediate or high risk, consult your obstetrician or genetic counselor immediately to discuss further diagnostic options and management.
Limitations
- ⚠Screening test only; does not provide a definitive diagnosis
- ⚠False positive and false negative results possible
- ⚠May not detect all chromosomal or structural abnormalities
- ⚠Results are probability-based and require interpretation by a healthcare provider
Risks & Considerations
- ●Minimal risk associated with blood draw, such as slight pain, bruising, or infection at the puncture site
Interfering Factors
- ●Inaccurate gestational age dating
- ●Multiple pregnancies (twins, triplets)
- ●Maternal weight
- ●Smoking status
- ●Diabetes mellitus
- ●Race/ethnicity
Compare With Similar Tests
| Test | Maternal Serum Screen 2 Dual Test Test | First Trimester Screening | Quad Screen | Non-Invasive Prenatal Testing (NIPT) | Amniocentesis |
|---|---|---|---|---|---|
| Comparison | Maternal Serum Screen 2 Dual Test Test | Combines blood test (PAPP-A, free beta-hCG) with nuchal translucency ultrasound at 11-13 weeks | Second trimester test measuring AFP, hCG, estriol, and inhibin A | Analyzes cell-free fetal DNA in maternal blood for chromosomal abnormalities with higher accuracy | Diagnostic test involving sampling amniotic fluid for definitive chromosomal analysis |
Frequently Asked Questions
What is the Maternal Serum Screen 2 Dual Test?
When is the best time to take this test?
Is fasting required for this test?
How accurate is the Maternal Serum Screen 2 Dual Test?
What do abnormal results mean?
What is the cost of the test at DNA Labs India?
Is home sample collection available?
How long does it take to get the results?
What are the parameters measured in this test?
Can this test detect all birth defects?
What should I do if I get a high-risk result?
Is this test safe for the baby?
Related Tests
Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
Book Your Test
Enter your details and we'll connect you within 15 minutes.