Maternal Serum Screen 4 Quadruple Test
Maternal Serum Screen 4 Quadruple Test test available at DNA Labs India for ₹4,500. Uses Chemiluminescent Immunoassay on Serum samples. Results in Same day. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
To measure the levels of AFP, Beta HCG, Free Estriol, and Inhibin A in maternal serum for evaluating the risk of Down syndrome, neural tube defects, and other chromosomal abnormalities.
- Test Code
- 1213
- Price
- ₹4,500
- Sample Type
- Serum
- Result Time
- Same day
- Fasting Required
- No
- Method
- Chemiluminescent Immunoassay
Sample Collection
Provide maternal date of birth, LMP or ultrasound date, IVF status, number of fetuses, diabetic status, body weight in kg, smoking history, and previous history of Trisomy 21 pregnancy. Fill the Maternal Serum Screen requisition form (Form 11).
Method: Venipuncture
Laboratory Analysis
A blood sample of 3 mL is collected from a vein in the arm using standard venipuncture technique.
Report Delivery
Label the sample properly and transport it refrigerated or frozen as per stability guidelines.
Timeline: Same day
Patient Instructions
About This Test
Who Should Get This Test
To measure the levels of AFP, Beta HCG, Free Estriol, and Inhibin A in maternal serum for evaluating the risk of Down syndrome, neural tube defects, and other chromosomal abnormalities.
How to Prepare
- Fast not required
- Provide all required maternal information
- Complete Form 11
- Sample collected between 14-22 weeks gestation, ideal 15-20 weeks
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This quadruple screen is a valuable non-invasive tool for assessing fetal risk. Early detection allows for informed decision-making and appropriate follow-up care."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Inadequate sample volume
- Missing requisition form
- Incorrect sample handling
- Sample beyond stability period
Understanding Your Results
Low risk
Risk is below the cutoff; typically no further action needed
High risk
Risk is elevated; recommend diagnostic testing such as amniocentesis
Borderline
May require repeat testing or additional evaluation
If the test results indicate a high risk for birth defects, consult your doctor immediately for further evaluation and counseling.
Limitations
- ⚠Screening test, not diagnostic
- ⚠False positives and false negatives possible
- ⚠Does not detect all birth defects
Risks & Considerations
- ●Minor bruising at blood draw site
- ●Rare infection
- ●Minimal risk from blood draw
Compare With Similar Tests
| Test | Maternal Serum Screen 4 Quadruple Test Test | Triple Marker Test | Integrated Prenatal Screen | Non-Invasive Prenatal Testing (NIPT) |
|---|---|---|---|---|
| Comparison | Maternal Serum Screen 4 Quadruple Test Test |
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