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Minimal Residual Disease (MRD) Monitoring for B-CLL Test

DNA Labs India | ISO 9001:2015 Certified

Minimal Residual Disease (MRD) Monitoring for B-CLL Test

Short Name: MRD B-CLL Test

Also known as: MRD Monitoring for CLL, Minimal Residual Disease Test, B-CLL MRD Assessment

Minimal Residual Disease (MRD) Monitoring for B-CLL Test test available at DNA Labs India for ₹17,000. Uses Flow Cytometry on Bone marrow aspirate and whole blood samples. Results in Results are typically available within 3 working days after sample receipt.. Free home collection in 300+ cities across India.

Flow CytometryAdults🏠 Home Collection

🩺 Medically Reviewed By

Overview

To detect minimal residual disease after treatment in B-CLL patients, helping to assess therapy effectiveness, guide further treatment decisions, and predict clinical outcomes such as progression-free survival.

Test Code
1245
Price
₹17,000
Sample Type
Bone marrow aspirate and whole blood
Result Time
Results are typically available within 3 working days after sample receipt.
Fasting Required
No
Method
Flow Cytometry
Step 1

Sample Collection

Ensure all mandatory information is provided: sample time point (chemotherapy time points), previous diagnostic immunophenotype report, clinical history, therapy details, and date/time of sample collection.

Method: Bone marrow aspiration and venipuncture

Step 2

Laboratory Analysis

Bone marrow aspiration is performed under local anesthesia; blood is drawn via venipuncture. Multiple samples may be collected for accuracy.

Step 3

Report Delivery

Apply pressure to the collection site to prevent bleeding. Monitor for signs of infection or discomfort. Follow post-procedure care instructions.

Timeline: Results are typically available within 3 working days after sample receipt.

Patient Instructions

1
Before the Test:Inform your doctor about any medications, health conditions, or previous treatments. Ensure all required documents are ready.
2
During the Test:The test involves a blood draw and possibly a bone marrow biopsy. The procedure may cause mild discomfort but is generally safe.
3
After the Test:Mild soreness at the collection site is normal. Resume normal activities as advised. Follow up for results and consultation.

About This Test

Who Should Get This Test

To detect minimal residual disease after treatment in B-CLL patients, helping to assess therapy effectiveness, guide further treatment decisions, and predict clinical outcomes such as progression-free survival.

How to Prepare

  • Collect 3 mL bone marrow aspirate in one green top (Sodium Heparin) tube
  • Collect 4 mL whole blood in two green top tubes
  • Mix samples thoroughly
  • Ship immediately at 18-22°C or 2-8°C
  • Do not freeze samples
  • Include 2-3 unstained bone marrow or peripheral smears if possible

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"MRD monitoring is essential for evaluating therapy efficacy in B-CLL, guiding treatment decisions, and predicting patient outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBone marrow aspirate and whole blood
Sample Volume3 mL bone marrow (1 mL min.) and 4 mL whole blood (3 mL min.)
ContainerGreen Top (Sodium Heparin) tubes
Collection MethodBone marrow aspiration and venipuncture

Sample Stability

Room Temperature
Refrigerator (2-8°C)
Frozen
Sample Rejection Criteria:
  • Insufficient sample volume
  • Improper container used
  • Sample hemolyzed or clotted
  • Missing mandatory clinical information
  • Delayed shipment beyond stability period

Understanding Your Results

MRD results indicate the presence or absence of residual cancer cells after treatment, helping to determine remission depth and guide management.
MRD Negative: No detectable cancer cells, suggesting deep remission and potentially better prognosis
MRD Positive: Cancer cells detected above sensitivity threshold, may require further treatment or monitoring
Results should be interpreted in conjunction with clinical history and other diagnostics by an oncologist
⚠️ When to Consult a Doctor:

Consult your oncologist if MRD results are positive, if symptoms such as fatigue or swollen lymph nodes persist, or for any concerns about treatment response or disease progression.

Limitations

  • Sensitivity limit may vary based on assay
  • Not all cancer cells may be detected due to heterogeneity
  • False negatives possible with low tumor burden
  • Requires specialized equipment and trained personnel

Risks & Considerations

  • Pain or discomfort at the biopsy site
  • Bleeding or hematoma
  • Infection at the collection site
  • Rare allergic reactions to local anesthesia

Interfering Factors

  • Sample contamination during collection
  • Improper handling or storage conditions
  • Hemodilution in bone marrow aspirate
  • Technical errors in flow cytometry analysis

Compare With Similar Tests

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Frequently Asked Questions

What is MRD monitoring for B-CLL?
MRD monitoring is a test that detects minimal residual disease—cancer cells remaining after treatment—in B-CLL patients using flow cytometry, helping to assess remission and guide therapy.
Why is MRD monitoring important for B-CLL?
It allows doctors to track treatment effectiveness, predict outcomes like progression-free survival, and make timely adjustments to therapy if cancer persists.
How is the MRD test performed?
The test involves collecting bone marrow aspirate and blood samples, which are analyzed using flow cytometry to quantify cancer cell levels.
What samples are needed for MRD monitoring?
Typically, 3 mL bone marrow (first pull aspirate) and 4 mL whole blood in green top tubes, with detailed clinical information.
How long does it take to get MRD test results?
Results are usually available within 3 working days after sample collection and processing.
What do MRD results mean?
MRD-negative indicates no detectable cancer cells (deep remission), while MRD-positive suggests residual disease, possibly requiring further treatment.
Are there any risks with the MRD test?
Risks are minimal and may include pain, bleeding, or infection at the biopsy site, but serious complications are rare.
Can MRD monitoring be done at home?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
What is the cost of MRD monitoring for B-CLL?
The test costs INR 17,000 at DNA Labs India, with free home collection available.
Is fasting required for the MRD test?
No, fasting is not required. However, providing mandatory clinical information is essential.
Who should order this MRD test?
Hematologists or oncologists typically order this test for B-CLL patients post-treatment or during monitoring.
How accurate is MRD monitoring for B-CLL?
MRD monitoring using flow cytometry is highly sensitive and accurate, but results should be interpreted by a specialist based on clinical context.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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