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MMR genes Gene MMR genes methylation analysis NGS Genetic Test

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MMR genes Gene MMR genes methylation analysis NGS Genetic Test

Short Name: MMR Methylation Analysis NGS Test

Also known as: MMR Methylation Test, Mismatch Repair Gene Methylation Analysis, MMR Epigenetic Test

MMR genes Gene MMR genes methylation analysis NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Genetic Methylation Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To detect methylation changes in MMR genes for assessing cancer risk, aiding in early diagnosis, genetic counseling, and personalized treatment strategies.

Test Code
2905
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Provide clinical history and undergo genetic counseling to draw a pedigree chart of affected family members.

Method: Venipuncture or FTA card spotting

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or one drop on FTA card; minimal discomfort.

Step 3

Report Delivery

Apply pressure to the puncture site; resume normal activities.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history review are recommended.
2
During the Test:Blood sample collection; analysis using NGS technology.
3
After the Test:Receive report in 3-4 weeks; discuss results with a healthcare provider.

About This Test

Who Should Get This Test

To detect methylation changes in MMR genes for assessing cancer risk, aiding in early diagnosis, genetic counseling, and personalized treatment strategies.

How to Prepare

  • Use sterile equipment
  • Label samples correctly
  • Transport at ambient room temperature
  • Avoid hemolysis

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This test is essential for identifying individuals at high risk of hereditary cancers, such as Lynch syndrome, due to MMR gene methylation, enabling early intervention and personalized care."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required for analysis
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or FTA card spotting

Sample Stability

Blood: 24-48 hours at room temperature
FTA card: Stable for weeks if stored properly
Sample Rejection Criteria:
  • Hemolyzed samples
  • Insufficient volume
  • Incorrect labeling
  • Contaminated samples

Understanding Your Results

Results indicate methylation status of MMR genes, which can signal increased cancer risk if methylation is detected.
📊

No Methylation Detected

Normal; low risk of MMR-related cancers

📊

Methylation Detected in One or More Genes

Abnormal; increased risk of hereditary cancers like Lynch syndrome; further evaluation recommended

📊

Inconclusive

Repeat testing or additional genetic tests may be needed

⚠️ When to Consult a Doctor:

Consult a doctor if results show methylation, if you have a family history of cancer, or if symptoms like unusual growths persist.

Limitations

  • ⚠May not detect all methylation variants
  • ⚠Results require clinical correlation
  • ⚠Limited to specific MMR genes analyzed
  • ⚠Cannot replace comprehensive genetic counseling

Risks & Considerations

  • ●Minimal risk from blood draw (bruising, infection)
  • ●Psychological impact of results
  • ●No significant physical risks

Interfering Factors

  • ●Poor sample quality
  • ●Contamination during collection
  • ●Recent blood transfusions
  • ●Improper storage conditions

Compare With Similar Tests

TestMMR genes Gene MMR genes methylation analysis NGS Genetic TestBRCA Gene TestMicrosatellite Instability (MSI) TestImmunohistochemistry (IHC) for MMR ProteinsComprehensive Cancer Gene Panel
ComparisonMMR genes Gene MMR genes methylation analysis NGS Genetic Test

Frequently Asked Questions

What is MMR genes methylation analysis?
It is a genetic test that detects methylation changes in mismatch repair genes, which can increase cancer risk.
Why is this test important?
It helps identify individuals at risk for hereditary cancers like Lynch syndrome, enabling early prevention and management.
How is the test performed?
Using next-generation sequencing (NGS) on a blood or DNA sample to analyze methylation patterns.
What is the cost of the test?
The test costs Rs 20000 INR, with free home sample collection available across India.
Is home collection available?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities.
How long does it take to get results?
Results are typically available in 3 to 4 weeks after sample collection.
What do the results mean?
No methylation indicates normal risk; methylation detected suggests increased cancer risk and need for further evaluation.
Are there any risks associated with the test?
Risks are minimal, mainly related to blood draw, such as bruising or infection.
Who should consider this test?
Individuals with a family history of cancer, personal history of related cancers, or symptoms suggestive of hereditary syndromes.
How accurate is the test?
The test uses advanced NGS technology for high accuracy, but results should be correlated with clinical findings.
Is the test covered by insurance?
Coverage varies; check with your insurance provider. DNA Labs India offers transparent pricing.
What should I do after receiving results?
Consult a healthcare provider or genetic counselor to discuss implications and next steps.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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