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DNA Labs India

MSH3 Gene Familial adenomatous polyposis type 4 NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

MSH3 Gene Familial adenomatous polyposis type 4 NGS Genetic Test

Short Name: MSH3 FAP Type 4 NGS Test

Also known as: Familial Adenomatous Polyposis Type 4, FAP Type 4, MSH3-related Polyposis

MSH3 Gene Familial adenomatous polyposis type 4 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample receipt.. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify pathogenic mutations in the MSH3 gene for the diagnosis of Familial Adenomatous Polyposis Type 4 and to assess the risk of developing colorectal cancer.

Test Code
2873
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks from sample receipt.
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Genetic counseling recommended. No specific preparation required.

Method: Venipuncture or finger prick

Step 2

Laboratory Analysis

Blood sample will be drawn by a trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the puncture site to stop bleeding.

Timeline: 3 to 4 weeks from sample receipt.

Patient Instructions

1
Before the Test:Genetic counseling to discuss implications and family history.
2
During the Test:Sample collection and analysis in the laboratory.
3
After the Test:Results interpretation and follow-up counseling.

About This Test

Who Should Get This Test

To identify pathogenic mutations in the MSH3 gene for the diagnosis of Familial Adenomatous Polyposis Type 4 and to assess the risk of developing colorectal cancer.

How to Prepare

  • Ensure proper identification
  • Use sterile equipment
  • Label samples correctly

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for MSH3 mutations is essential for early detection and management of FAP Type 4, reducing the risk of colorectal cancer through timely interventions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or finger prick

Sample Stability

Room Temperature
Refrigerated
Sample Rejection Criteria:
  • Insufficient sample volume
  • Hemolyzed or clotted sample
  • Improperly labeled sample

Understanding Your Results

Results indicate the presence or absence of mutations in the MSH3 gene associated with FAP Type 4.
📊

No pathogenic variant detected

Low risk for FAP Type 4, but clinical correlation is advised.

📊

Pathogenic variant detected

Diagnosis of FAP Type 4 confirmed, increased risk for colorectal cancer. Further management recommended.

⚠️ When to Consult a Doctor:

Consult a geneticist or oncologist immediately after receiving positive results for appropriate management and surveillance.

Limitations

  • ⚠May not detect all types of mutations
  • ⚠Requires interpretation by a geneticist
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minimal risk from blood draw
  • ●Psychological impact of results

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Hemolyzed blood sample

Compare With Similar Tests

TestMSH3 Gene Familial adenomatous polyposis type 4 NGS Genetic TestAPC Gene TestKRAS Gene Test
ComparisonMSH3 Gene Familial adenomatous polyposis type 4 NGS Genetic TestFor FAP Type 1, different gene involved.For other cancers, not specific to FAP.

Frequently Asked Questions

What is the MSH3 Gene NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing to detect mutations in the MSH3 gene, which is associated with Familial Adenomatous Polyposis Type 4.
Who should consider this test?
Individuals with a family history of FAP, symptoms like abdominal pain or blood in stool, or those with multiple colorectal polyps.
What are the symptoms of FAP Type 4?
Symptoms include abdominal pain, rectal bleeding, diarrhea, constipation, and weight loss.
How is the test performed?
A blood sample or extracted DNA is analyzed using NGS technology to identify mutations in the MSH3 gene.
What is the cost of the test?
The cost is INR 20,000 at DNA Labs India.
Is home sample collection available?
Yes, free home sample collection is available for online bookings across India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks.
What do the results mean?
Results indicate whether pathogenic mutations in the MSH3 gene are detected, which can confirm FAP Type 4 and assess cancer risk.
Is genetic counseling required?
Yes, genetic counseling is recommended before and after testing to understand the implications.
Can this test detect all mutations?
While NGS is comprehensive, it may not detect all types of mutations, and results should be interpreted by a geneticist.
What are the risks of the test?
The test involves minimal risk from blood draw, but there may be psychological impacts based on results.
How accurate is the test?
The test is highly accurate using advanced NGS technology, but accuracy depends on sample quality and interpretation.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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