MSH6 Gene Mismatch repair cancer syndrome NGS Genetic Test
Short Name: MSH6 Gene Test
Also known as: Lynch Syndrome, Hereditary Nonpolyposis Colorectal Cancer, MSH6-Related Cancer Syndrome
MSH6 Gene Mismatch repair cancer syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To identify mutations in the MSH6 gene associated with mismatch repair cancer syndrome for risk assessment, early detection, and management of hereditary cancer syndromes.
- Test Code
- 2901
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation required. Provide clinical history and undergo genetic counseling to understand test implications.
Method: Blood Draw or FTA Card
Laboratory Analysis
A blood sample will be drawn by a trained phlebotomist, or a FTA card with a blood drop may be used.
Report Delivery
Apply pressure to the puncture site to stop bleeding. The sample will be sent to the laboratory for analysis.
Timeline: 3 to 4 weeks
Patient Instructions
About This Test
Who Should Get This Test
To identify mutations in the MSH6 gene associated with mismatch repair cancer syndrome for risk assessment, early detection, and management of hereditary cancer syndromes.
How to Prepare
- Ensure proper patient identification
- Use sterile collection equipment
- Label samples correctly with patient details
- Handle FTA cards as per instructions
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for MSH6 mutations is crucial for individuals with a family history of cancer to assess risk and guide preventive measures, including enhanced surveillance and risk-reducing strategies."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient sample volume
- Hemolyzed or clotted blood samples
- Incorrect labeling or missing patient information
- Contaminated samples
Understanding Your Results
Pathogenic variant detected
Increased risk for Lynch syndrome-associated cancers. Recommend enhanced surveillance, genetic counseling, and possible risk-reducing interventions.
No pathogenic variant detected
Reduced risk for MSH6-related cancer syndrome, but not zero. Follow standard cancer screening guidelines based on family history.
Variant of uncertain significance (VUS)
Further testing and family studies may be needed. Genetic counseling is recommended for management.
If a pathogenic variant is detected, consult an oncologist or genetic counselor immediately for personalized management and surveillance plans.
Limitations
- ⚠May not detect all types of mutations, such as large deletions or rearrangements
- ⚠Does not predict cancer onset with certainty; risk assessment requires clinical correlation
- ⚠Requires genetic counseling for accurate interpretation
- ⚠Limited to MSH6 gene; other genes may be involved in Lynch syndrome
Risks & Considerations
- ●Minimal risk from blood draw, such as bruising or infection
- ●Psychological impact of results, including anxiety or stress
- ●Potential for uncertain results requiring further testing
Interfering Factors
- ●Sample contamination
- ●Degraded DNA
- ●Technical errors in sequencing
- ●Hemolyzed blood samples
Compare With Similar Tests
| Test | MSH6 Gene Mismatch repair cancer syndrome NGS Genetic Test | MLH1 Gene Test | MSH2 Gene Test | PMS2 Gene Test | Lynch Syndrome Comprehensive Panel |
|---|---|---|---|---|---|
| Comparison | MSH6 Gene Mismatch repair cancer syndrome NGS Genetic Test |
Frequently Asked Questions
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