MUTYH Gene Familial adenomatous polyposis type 2 NGS Genetic Test
Short Name: MUTYH Gene FAP Type 2 NGS Test
Also known as: Familial Adenomatous Polyposis Type 2, MUTYH-associated polyposis, FAP Type 2
MUTYH Gene Familial adenomatous polyposis type 2 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS, Next-Generation Sequencing on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Results are typically available within 3 to 4 weeks after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the MUTYH Gene FAP Type 2 NGS Genetic Test is to identify pathogenic mutations in the MUTYH gene, enabling early diagnosis of Familial Adenomatous Polyposis Type 2. This facilitates proactive medical management, including regular screening, preventive measures, and informed decision-making to reduce the risk of colorectal cancer.
- Test Code
- 2872
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Results are typically available within 3 to 4 weeks after sample collection.
- Fasting Required
- No
- Method
- NGS, Next-Generation Sequencing
Sample Collection
No specific preparation is required. Ensure to provide accurate clinical and family history information.
Method: Blood draw or saliva sample
Laboratory Analysis
A blood sample will be drawn from a vein in the arm, or a saliva sample may be collected using a kit. For FTA card, a drop of blood is applied.
Report Delivery
Apply pressure to the puncture site to prevent bleeding. Resume normal activities unless advised otherwise.
Timeline: Results are typically available within 3 to 4 weeks after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the MUTYH Gene FAP Type 2 NGS Genetic Test is to identify pathogenic mutations in the MUTYH gene, enabling early diagnosis of Familial Adenomatous Polyposis Type 2. This facilitates proactive medical management, including regular screening, preventive measures, and informed decision-making to reduce the risk of colorectal cancer.
How to Prepare
- Bring a valid ID and doctor's prescription if available
- Inform the phlebotomist of any bleeding disorders or medications
- For saliva collection, avoid eating or drinking 30 minutes prior
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Genetic testing for MUTYH mutations is essential for individuals with a family history of FAP type 2 to guide personalized screening, surveillance, and preventive strategies to reduce cancer risk."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Improperly labeled or contaminated samples
Understanding Your Results
Pathogenic mutation detected in the MUTYH gene, confirming diagnosis of FAP type 2. Increased risk for colorectal cancer. Recommend genetic counseling, regular colonoscopies, and possible surgical consultation.
Result type: Positive
No pathogenic mutations detected. However, clinical symptoms may warrant further evaluation. Does not entirely rule out FAP type 2 if strong family history exists.
Result type: Negative
A genetic variant was found, but its clinical significance is unknown. Requires periodic re-evaluation and genetic counseling.
Result type: Variant of Uncertain Significance (VUS)
Consult a doctor immediately if you test positive for a MUTYH mutation, have symptoms of FAP type 2, or have a family history of the condition. Regular follow-ups are crucial for monitoring and management.
Limitations
- ⚠May not detect all types of MUTYH gene mutations, such as large deletions or duplications
- ⚠Results require interpretation by a genetic counselor or healthcare provider
- ⚠False negatives are possible but rare with NGS technology
- ⚠Does not replace clinical evaluation or other diagnostic tests like colonoscopy
Risks & Considerations
- ●Minimal risks from blood draw, such as bruising or infection at the puncture site
- ●Psychological impact of genetic results, addressed through counseling
- ●No significant risks from saliva collection
Interfering Factors
- ●Sample contamination or degradation
- ●Insufficient DNA quantity or quality
- ●Recent blood transfusions may affect results
- ●Technical errors in sequencing or analysis
Compare With Similar Tests
| Test | MUTYH Gene Familial adenomatous polyposis type 2 NGS Genetic Test | APC Gene Test for FAP Type 1 | Comprehensive Colorectal Cancer Panel | Colonoscopy Screening |
|---|---|---|---|---|
| Comparison | MUTYH Gene Familial adenomatous polyposis type 2 NGS Genetic Test | Detects mutations in the APC gene, which causes FAP type 1. MUTYH test is specific for FAP type 2, an autosomal recessive condition. | Includes multiple genes associated with hereditary colorectal cancer, providing broader analysis but at higher cost. | A diagnostic procedure to visualize polyps, not a genetic test. Genetic testing identifies underlying mutations for risk assessment. |
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