NPM1 Gene Mutation Test
Short Name: NPM1 Mutation Test
Also known as: NPM1 gene mutation analysis, NPM1 test for AML
NPM1 Gene Mutation Test test available at DNA Labs India for ₹5,500. Uses Real Time PCR on Whole blood or Bone marrow samples. Results in Reports available within 48-72 hours after sample receipt at the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To detect mutations in the NPM1 gene associated with acute myeloid leukemia for diagnosis, prognosis, and treatment planning.
- Test Code
- 1315
- Price
- ₹5,500
- Sample Type
- Whole blood or Bone marrow
- Result Time
- Reports available within 48-72 hours after sample receipt at the laboratory.
- Fasting Required
- No
- Method
- Real Time PCR
Sample Collection
Ensure the Genomics Clinical Information Requisition Form (Form 20) is duly filled and submitted.
Method: Venipuncture or Bone marrow aspiration
Laboratory Analysis
Blood drawn from a vein in the arm or bone marrow collected under sterile conditions by a trained professional.
Report Delivery
Apply pressure to the puncture site to prevent bruising and monitor for any adverse effects.
Timeline: Reports available within 48-72 hours after sample receipt at the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
To detect mutations in the NPM1 gene associated with acute myeloid leukemia for diagnosis, prognosis, and treatment planning.
How to Prepare
- Fill Genomics Clinical Information Requisition Form (Form 20) accurately
- Use correct Lavender Top (EDTA) tube for sample
- Label sample with patient details
- Ship sample refrigerated, do not freeze
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Early detection of NPM1 mutations guides personalized therapy in acute myeloid leukemia, improving patient prognosis and treatment outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Unlabeled or mislabeled samples
- Improperly stored samples
- Insufficient sample volume
- Contaminated or hemolyzed samples
Understanding Your Results
Positive
Mutation detected, associated with increased risk for AML. Consult an oncologist or hematologist for further evaluation and personalized treatment.
Negative
No mutation detected. However, clinical correlation with symptoms and other tests is recommended.
Indeterminate
Test inconclusive due to sample issues or technical errors. Repeat testing or additional diagnostic methods may be required.
Upon receiving positive results, if symptoms persist, or for genetic counseling, consult a hematologist or oncologist immediately.
Limitations
- ⚠Only detects specific mutations in the NPM1 gene
- ⚠Cannot identify all genetic variants
- ⚠Results should be interpreted in clinical context
- ⚠Not a standalone diagnostic tool
Risks & Considerations
- ●Minor bruising or pain at puncture site
- ●Rare risk of infection
- ●Minimal discomfort during blood draw
Interfering Factors
- ●Sample contamination
- ●Improper storage conditions
- ●Hemolyzed or lipemic samples
- ●Recent blood transfusion
Compare With Similar Tests
| Test | NPM1 Gene Mutation Test | FLT3 Gene Mutation Test | CEBPA Gene Mutation Test | Chromosomal Analysis |
|---|---|---|---|---|
| Comparison | NPM1 Gene Mutation Test | Both are genetic tests for AML, but FLT3 targets different mutations with distinct treatment implications. | CEBPA tests for mutations in another gene associated with AML, aiding in comprehensive genetic profiling. | Detects chromosomal abnormalities, while NPM1 is a specific gene mutation test for targeted diagnosis. |
Frequently Asked Questions
What is the NPM1 Gene Mutation Test?
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Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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