NUDT15 Gene Mutation Analysis Test
Short Name: NUDT15 Mutation Test
Also known as: NUDT15 Genotyping, Thiopurine Sensitivity Test
NUDT15 Gene Mutation Analysis Test test available at DNA Labs India for ₹7,500. Uses Sanger Sequencing on Peripheral blood samples. Results in Reports are typically available within 12 days after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of NUDT15 gene mutation analysis is to identify genetic variants that predispose individuals to thiopurine drug toxicity. This information helps in personalizing treatment plans, adjusting drug doses, or avoiding thiopurines altogether to prevent serious side effects such as bone marrow suppression and infections.
- Test Code
- 3132
- Price
- ₹7,500
- Sample Type
- Peripheral blood
- Result Time
- Reports are typically available within 12 days after sample collection.
- Fasting Required
- No
- Method
- Sanger Sequencing
Sample Collection
No specific preparation is required. Ensure a doctor's prescription is available if needed, though it may not be required for certain cases like surgery or pregnancy.
Method: Venipuncture
Laboratory Analysis
A healthcare professional will collect a peripheral blood sample via venipuncture from a vein in the arm.
Report Delivery
Apply pressure to the puncture site to prevent bleeding. Resume normal activities unless otherwise advised.
Timeline: Reports are typically available within 12 days after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of NUDT15 gene mutation analysis is to identify genetic variants that predispose individuals to thiopurine drug toxicity. This information helps in personalizing treatment plans, adjusting drug doses, or avoiding thiopurines altogether to prevent serious side effects such as bone marrow suppression and infections.
How to Prepare
- Bring a valid ID and doctor's prescription if applicable
- Wear loose clothing to facilitate blood draw
- Inform the phlebotomist of any bleeding disorders or medications
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This test is essential for patients on thiopurine drugs to prevent severe side effects like bone marrow suppression. Genetic testing enables personalized dosing and safer treatment."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient sample volume
- Contaminated or hemolyzed samples
- Incorrect sample labeling
Understanding Your Results
Negative (No Mutation)
No pathogenic NUDT15 variants detected. Standard thiopurine dosing may be considered, but clinical monitoring is still advised.
Action: Consult with your doctor for personalized treatment planning.
Positive (Mutation Detected)
Pathogenic NUDT15 variant identified, indicating higher risk of thiopurine-induced toxicity.
Action: Discuss dose adjustment or alternative therapies with your healthcare provider. Genetic counseling may be recommended.
Consult your doctor if you experience symptoms like nausea, vomiting, fever, fatigue, or jaundice while on thiopurine drugs, or before starting such therapy if you have a family history of toxicity.
Limitations
- ⚠This test does not detect all possible genetic variants in the NUDT15 gene
- ⚠Results should be interpreted in conjunction with clinical history and other tests
- ⚠May not predict the severity of toxicity in all cases
Risks & Considerations
- ●Minor bruising or pain at the blood draw site
- ●Rare risk of infection or excessive bleeding
- ●No significant long-term risks associated with the test
Interfering Factors
- ●Hemolyzed or lipemic blood samples may affect test accuracy
- ●Recent blood transfusions could interfere with genetic analysis
- ●Improper sample storage or handling
Compare With Similar Tests
| Test | NUDT15 Gene Mutation Analysis | TPMT Gene Mutation Analysis | Pharmacogenomic Panel |
|---|---|---|---|
| Comparison | NUDT15 Gene Mutation Analysis | Both tests assess thiopurine drug metabolism, but NUDT15 focuses on a different gene linked to toxicity in Asian populations. | A broader test that includes multiple genes affecting drug response, whereas NUDT15 analysis is specific to thiopurine toxicity. |
Frequently Asked Questions
What is NUDT15 gene mutation analysis?
Why is this test important?
Who should consider getting this test?
How is the test performed?
What is the cost of the test?
Is fasting required before the test?
How long does it take to get results?
What do the results mean?
Are there any risks associated with the test?
Can this test be done at home?
Is a doctor's prescription needed?
How accurate is the test?
Related Tests
Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
Book Your Test
Enter your details and we'll connect you within 15 minutes.