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DNA Labs India

PALB2 Gene Breast cancer, susceptibility to NGS Genetic Test

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PALB2 Gene Breast cancer, susceptibility to NGS Genetic Test

Short Name: PALB2 Gene Test

Also known as: PALB2 Mutation Analysis, Breast Cancer Susceptibility Gene Test

PALB2 Gene Breast cancer, susceptibility to NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic TestFemaleAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To identify mutations in the PALB2 gene that increase susceptibility to breast and ovarian cancer, enabling risk assessment, early detection, and personalized preventive care.

Test Code
2840
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Clinical history of the patient and a genetic counseling session to draw a pedigree chart of family members affected with breast or ovarian cancer.

Method: Venipuncture or FTA Card

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or one drop on FTA card.

Step 3

Report Delivery

Sample processed for NGS analysis; results delivered in 3-4 weeks.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling session to assess family history and discuss test implications.
2
During the Test:Blood sample collection via venipuncture or FTA card.
3
After the Test:Results available in 3-4 weeks; follow-up counseling recommended.

About This Test

Who Should Get This Test

To identify mutations in the PALB2 gene that increase susceptibility to breast and ovarian cancer, enabling risk assessment, early detection, and personalized preventive care.

How to Prepare

  • Ensure proper identification and labeling of the sample.
  • Use sterile equipment for blood collection.
  • For FTA card, apply one drop of blood and allow to dry.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture or FTA Card

Sample Stability

Blood samples: stable at room temperature for 24 hours.
Extracted DNA: stable at -20°C for long-term storage.
Sample Rejection Criteria:
  • Hemolyzed or insufficient sample volume.
  • Incorrect labeling or missing patient information.

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the PALB2 gene. A positive result suggests increased risk for breast and ovarian cancer, while a negative result indicates no detected mutation, though risk may still exist due to other factors.
📊

Positive for PALB2 mutation

Significantly increased lifetime risk of breast cancer (35-58%) and elevated ovarian cancer risk. Recommend enhanced surveillance, genetic counseling, and discussion of preventive options.

Action: Consult with an oncologist or genetic specialist for personalized management.

📊

Negative for PALB2 mutation

No pathogenic mutation detected in the PALB2 gene. However, breast cancer risk may still be influenced by other genetic or environmental factors.

Action: Continue standard breast cancer screening and discuss family history with a healthcare provider.

⚠️ When to Consult a Doctor:

If you experience symptoms like breast lumps, changes in breast shape, or nipple discharge, or if you have a family history of breast/ovarian cancer and are considering genetic testing.

Limitations

  • ⚠Test may not detect all genetic variants or mutations in non-coding regions.
  • ⚠Results require interpretation by a genetic counselor or healthcare provider.
  • ⚠Does not replace standard breast cancer screening methods like mammography.

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection.
  • ●Psychological impact of genetic results; counseling provided.

Frequently Asked Questions

What is the PALB2 gene?
The PALB2 gene is a tumor suppressor gene that helps repair DNA and prevent cancer. Mutations in this gene can increase the risk of breast and ovarian cancer.
How does a PALB2 mutation increase breast cancer risk?
Mutations in PALB2 impair DNA repair mechanisms, leading to uncontrolled cell growth and a 35-58% lifetime risk of developing breast cancer.
Who should consider this genetic test?
Individuals with a family history of breast or ovarian cancer, personal history of early-onset breast cancer, or those referred for genetic counseling.
What is the cost of the PALB2 gene test?
The test costs INR 20,000, which includes sample collection and analysis. Home collection is available across India.
How is the test performed?
A blood sample or DNA extract is analyzed using next-generation sequencing (NGS) technology to detect mutations in the PALB2 gene.
What does a positive result mean?
A positive result indicates a pathogenic PALB2 mutation, significantly increasing breast and ovarian cancer risk. Genetic counseling and enhanced screening are recommended.
What are the next steps after a positive result?
Consult with an oncologist or genetic specialist to discuss surveillance options, preventive measures, and family testing.
Is the test covered by insurance?
Coverage varies by insurance plan. Check with your provider; schemes like PMJAY or CGHS may not cover genetic tests.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
What is the accuracy of the test?
The NGS technology used provides high accuracy in detecting PALB2 gene mutations, but results should be interpreted by a healthcare professional.
Can men undergo this test?
While breast cancer is more common in women, men with a family history of PALB2 mutations may also benefit from testing, as mutations can increase cancer risk in both genders.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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