PIK3CA Mutation Analysis Test
Short Name: PIK3CA Mutation
Also known as: PIK3CA Gene Mutation Test, PIK3CA Mutation Analysis, PIK3CA Targeted Mutation Testing
PIK3CA Mutation Analysis Test test available at DNA Labs India for ₹7,500. Uses PCR, Sequencing on FFPE tissue block samples. Results in Samples received by Tuesday 11 am yield reports on the following Monday. TAT is typically 6 days.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify mutations in the PIK3CA gene from tumor tissue. This information helps oncologists determine prognosis, classify tumors, and guide targeted therapy decisions.
- Test Code
- 3556
- Price
- ₹7,500
- Sample Type
- FFPE tissue block
- Result Time
- Samples received by Tuesday 11 am yield reports on the following Monday. TAT is typically 6 days.
- Fasting Required
- No
- Method
- PCR, Sequencing
Sample Collection
No patient preparation is required. The referring clinician must ensure the FFPE tissue block contains at least 10% tumor cells and complete the NGS requisition form (Form 40).
Method: Surgical biopsy / excision
Laboratory Analysis
No specific action is required by the patient as the test is performed on an FFPE tissue block provided by the pathology department.
Report Delivery
The tissue block is transported at room temperature to the laboratory. The patient or clinician may track the report online once available.
Timeline: Samples received by Tuesday 11 am yield reports on the following Monday. TAT is typically 6 days.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify mutations in the PIK3CA gene from tumor tissue. This information helps oncologists determine prognosis, classify tumors, and guide targeted therapy decisions.
How to Prepare
- Submit formalin-fixed paraffin-embedded (FFPE) tissue block
- Ship at room temperature
- Block must have at least 10% tumor tissue
- Duly filled NGS Test Requisition Form (Form 40) is mandatory
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"PIK3CA mutation status is an important biomarker for selecting cancer patients who may benefit from PI3K pathway inhibitors. This test provides actionable information for treatment planning in breast, colorectal, ovarian, and other solid tumors."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Tumor content below 10%
- Incomplete or missing NGS requisition form (Form 40)
- Non-FFPE specimen or inadequate sample
Understanding Your Results
Mutation not detected
The tissue sample does not show the tested PIK3CA mutations.
Mutation detected
A positive result indicates the presence of a PIK3CA mutation. Consult your oncologist for clinical correlation and targeted therapy options.
Consult your oncologist if the test result is positive, if symptoms persist, or if you have questions about treatment options.
Limitations
- ⚠This test only detects mutations in the regions covered by the PCR/sequencing assay
- ⚠It is not a germline test and does not assess inherited cancer risk
- ⚠Results must be interpreted in the context of histopathological findings
Risks & Considerations
- ●No direct risks from the laboratory test itself. The main risk is from the biopsy procedure used to obtain the tissue sample.
Interfering Factors
- ●Insufficient tumor content (<10%) in the FFPE block
- ●Poor DNA quality due to prolonged formalin fixation
- ●Presence of PCR inhibitors in the tissue sample
Frequently Asked Questions
What is the PIK3CA gene?
Why is the PIK3CA Mutation Analysis Test done?
What is the cost of the PIK3CA Mutation Analysis Test?
What sample is required for this test?
Do I need to fast before this test?
How long will it take to get the report?
Is home sample collection available for this test?
What does a positive PIK3CA mutation result mean?
What does a negative result mean?
Are there any risks associated with this test?
Can this test be performed on a blood sample?
How should I prepare for this test?
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