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PRKCD Gene Autoimmune lymphoproliferative syndrome type 3 NGS Genetic Test

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PRKCD Gene Autoimmune lymphoproliferative syndrome type 3 NGS Genetic Test

Short Name: PRKCD Gene ALPS Type 3 NGS Test

Also known as: ALPS Type 3, PRKCD-related Autoimmune Lymphoproliferative Syndrome

PRKCD Gene Autoimmune lymphoproliferative syndrome type 3 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the PRKCD gene for diagnosing Autoimmune Lymphoproliferative Syndrome Type 3, enabling accurate clinical management and genetic counseling.

Test Code
4850
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

No special preparation required. Provide clinical history and family pedigree during genetic counseling.

Method: Venipuncture or Finger prick for FTA Card

Step 2

Laboratory Analysis

A trained phlebotomist will collect a blood sample via venipuncture or a finger prick for FTA card.

Step 3

Report Delivery

Apply pressure to the puncture site to stop bleeding. Keep the sample at ambient temperature for transport.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Schedule a genetic counseling session to discuss symptoms, family history, and test implications.
2
During the Test:Sample collection and laboratory analysis using NGS technology.
3
After the Test:Receive the genetic report and discuss results with a healthcare provider for management planning.

About This Test

Who Should Get This Test

To identify mutations in the PRKCD gene for diagnosing Autoimmune Lymphoproliferative Syndrome Type 3, enabling accurate clinical management and genetic counseling.

How to Prepare

  • Ensure proper labeling of the sample
  • Use sterile collection equipment
  • Transport sample to the lab within 24 hours

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for PRKCD mutations is essential for accurate diagnosis of ALPS Type 3, which can inform treatment strategies such as immunosuppressive therapy and monitoring for complications like lymphoma."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 ml blood
ContainerEDTA tube or FTA Card
Collection MethodVenipuncture or Finger prick for FTA Card

Sample Stability

Blood samples stable for 24 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Improperly labeled samples

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the PRKCD gene. Consult a genetic specialist for detailed interpretation.
Positive result: Pathogenic mutation in PRKCD gene detected, consistent with ALPS Type 3 diagnosis
Negative result: No pathogenic mutations detected; clinical correlation recommended
Variant of uncertain significance (VUS): Further testing or family studies may be needed
⚠️ When to Consult a Doctor:

If symptoms of ALPS are present, such as enlarged lymph nodes, anemia, or recurrent infections, or if there is a family history of autoimmune disorders.

Limitations

  • ⚠May not detect all genetic variants, including deep intronic mutations
  • ⚠Variants of uncertain significance (VUS) may be identified
  • ⚠Does not rule out other genetic causes of ALPS

Risks & Considerations

  • ●Minimal risk from blood draw (e.g., bruising, infection)
  • ●Psychological impact of genetic diagnosis on patient and family

Interfering Factors

  • ●Poor sample quality
  • ●Contamination during collection or processing
  • ●Insufficient DNA yield

Compare With Similar Tests

TestPRKCD Gene Autoimmune lymphoproliferative syndrome type 3 NGS Genetic TestFAS Gene ALPS Type 1a NGS TestCASP10 Gene ALPS Type 2 NGS TestImmunoglobulin Levels TestLymphocyte Subset Analysis
ComparisonPRKCD Gene Autoimmune lymphoproliferative syndrome type 3 NGS Genetic Test

Frequently Asked Questions

What is PRKCD Gene Autoimmune Lymphoproliferative Syndrome Type 3?
ALPS Type 3 is a rare genetic disorder caused by mutations in the PRKCD gene, leading to immune dysregulation and autoimmune symptoms such as enlarged lymph nodes and cytopenias.
What are the symptoms of ALPS Type 3?
Symptoms include chronic lymphadenopathy, anemia, low platelet counts, hepatosplenomegaly, recurrent infections, autoimmune diseases, and increased lymphoma risk.
How is ALPS Type 3 diagnosed?
Diagnosis involves clinical evaluation, blood tests, and genetic testing to identify mutations in the PRKCD gene using NGS technology.
What is NGS genetic testing?
Next-Generation Sequencing (NGS) is a high-throughput method that sequences large DNA regions to detect genetic mutations accurately.
What is the cost of the PRKCD Gene ALPS Type 3 NGS Test?
The test costs INR 20,000, which includes home sample collection across India.
Is home sample collection available?
Yes, free home sample collection is available for online bookings in numerous cities across India.
How long does it take to get the test results?
Results are typically available within 3 to 4 weeks after sample collection.
What sample type is required for the test?
The test requires blood, extracted DNA, or one drop of blood on an FTA card.
Is fasting required before the test?
No, fasting is not required for this genetic test.
What does a positive test result mean?
A positive result indicates a pathogenic mutation in the PRKCD gene, confirming ALPS Type 3 diagnosis and guiding treatment.
Can this test be used for family screening?
Yes, genetic testing can help identify carriers and at-risk family members through pedigree analysis.
Is the test covered by insurance?
Coverage varies; it is not typically covered under government schemes like PMJAY, but private insurance may offer partial coverage. Check with your provider.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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