RET Gene Multiple endocrine neoplasia type 2A NGS Genetic Test
Short Name: RET MEN2A NGS
Also known as: MEN2A Genetic Test, RET Gene Mutation Test, RET NGS Test
RET Gene Multiple endocrine neoplasia type 2A NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify disease-causing mutations in the RET gene to confirm a diagnosis of MEN2A, assess the risk of developing associated tumors, and guide clinical management including prophylactic surgery and surveillance. It also aids in cascade screening of at-risk family members.
- Test Code
- 6003
- CPT Code
- 81405
- ICD Code
- E31.22
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation is required. However, a genetic counseling session is recommended to discuss the implications of testing. Please provide a detailed clinical history and family pedigree.
Method: Venipuncture or Fingerstick
Laboratory Analysis
Blood sample will be collected by a trained phlebotomist. For FTA card, a simple fingerstick blood spot is collected.
Report Delivery
No restrictions. You can resume normal activities immediately.
Timeline: 3 to 4 weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify disease-causing mutations in the RET gene to confirm a diagnosis of MEN2A, assess the risk of developing associated tumors, and guide clinical management including prophylactic surgery and surveillance. It also aids in cascade screening of at-risk family members.
How to Prepare
- Use EDTA tube for blood collection
- If using FTA card, ensure the card is properly labeled and dried
- Transport samples at ambient temperature
- Avoid hemolysis
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Early identification of RET mutations is critical for prophylactic interventions and family screening."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed blood sample
- Clotted blood sample
- Insufficient sample volume
- Improperly labeled sample
- Sample received after prolonged transit without proper storage
Understanding Your Results
Pathogenic variant detected
Confirms diagnosis of MEN2A. Prophylactic thyroidectomy and surveillance for pheochromocytoma and hyperparathyroidism are recommended.
Action: Consult with genetic counselor and endocrinologist for management.
Likely pathogenic variant detected
High likelihood of disease association. Further family studies may be needed.
Action: Consider clinical surveillance and family screening.
Variant of uncertain significance (VUS)
Clinical significance is unclear. Additional testing or segregation analysis may be required.
Action: Discuss with geneticist for further evaluation.
No pathogenic variant detected
No evidence of MEN2A-associated RET mutation. However, clinical diagnosis should be reconsidered if strong suspicion remains.
Action: Consider testing for other genes or alternative diagnoses.
If you have a family history of MEN2A, or if you have symptoms such as thyroid nodules, high blood pressure, or elevated calcium levels, consult your physician for evaluation and possible genetic testing.
Limitations
- ⚠This test detects mutations in the RET gene only; other genes associated with MEN syndromes are not analyzed.
- ⚠Large deletions/duplications may not be detected by NGS alone; additional testing may be required.
- ⚠Variants of uncertain significance (VUS) may be reported; further family studies may be needed.
- ⚠Test does not assess somatic mutations in tumor tissue.
Risks & Considerations
- ●Minimal risk of bruising or infection at the blood draw site
- ●Psychological impact of genetic results
- ●Potential for incidental findings
Interfering Factors
- ●Contamination of sample with foreign DNA
- ●Insufficient DNA quantity or quality
- ●Presence of hematologic malignancies causing clonal hematopoiesis
- ●Recent blood transfusion (within 2 weeks) may dilute DNA
Compare With Similar Tests
| Test | RET Gene Multiple endocrine neoplasia type 2A NGS Genetic Test | RET Gene Single Site Analysis | MEN1 Gene Sequencing | Comprehensive Cancer Panel |
|---|---|---|---|---|
| Comparison | RET Gene Multiple endocrine neoplasia type 2A NGS Genetic Test | Targeted testing for a known familial mutation. Less comprehensive than NGS, but faster and cheaper. | Tests for MEN1 gene associated with MEN1 syndrome, not MEN2A. | Includes multiple genes including RET, but more expensive and may not be necessary for MEN2A suspicion. |
Frequently Asked Questions
What is MEN2A?
How is the RET gene related to MEN2A?
What is the cost of the RET gene MEN2A NGS test?
What sample is required for this test?
How long does it take to get results?
Is fasting required before the test?
Will I receive raw data files?
Can this test be done for children?
Is genetic counseling included?
What does a positive result mean?
Are there any risks associated with the test?
Is this test covered by insurance?
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