RET Gene Multiple endocrine neoplasia type 2B NGS Genetic Test
Short Name: RET MEN2B NGS Test
Also known as: MEN2B Genetic Test, RET Gene Mutation Analysis, RET NGS Panel
RET Gene Multiple endocrine neoplasia type 2B NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are typically delivered within 3 to 4 weeks after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of this test is to detect pathogenic mutations in the RET gene that cause Multiple Endocrine Neoplasia Type 2B. It is used for confirming diagnosis in symptomatic individuals, predictive testing in at-risk family members, and guiding clinical management such as prophylactic thyroidectomy and surveillance for associated tumors.
- Test Code
- 6005
- CPT Code
- 81405
- ICD Code
- E31.22
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are typically delivered within 3 to 4 weeks after sample receipt.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No fasting required. Avoid blood transfusion for at least 2 weeks prior to sample collection. Inform the lab if you have had a bone marrow transplant or recent blood transfusion.
Method: Venipuncture or Fingerstick
Laboratory Analysis
A trained phlebotomist will collect a blood sample from a vein in your arm. For FTA card, a fingerstick blood drop is collected.
Report Delivery
No special precautions. You can resume normal activities immediately.
Timeline: Reports are typically delivered within 3 to 4 weeks after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to detect pathogenic mutations in the RET gene that cause Multiple Endocrine Neoplasia Type 2B. It is used for confirming diagnosis in symptomatic individuals, predictive testing in at-risk family members, and guiding clinical management such as prophylactic thyroidectomy and surveillance for associated tumors.
How to Prepare
- For blood sample: Use EDTA tube, mix gently.
- For FTA card: Apply blood spots, air dry, and place in provided envelope.
- Label sample with patient name, date of birth, and collection date.
- Transport at ambient temperature (15-30°C) to the lab.
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"Early detection of RET mutations is critical for managing MEN2B. This test provides actionable genetic information to guide prophylactic thyroidectomy and surveillance for pheochromocytoma."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Sample not labeled correctly
- Sample received after prolonged transit without proper temperature control
Understanding Your Results
Positive (Pathogenic mutation detected)
Confirms diagnosis of MEN2B. Prophylactic thyroidectomy and surveillance for pheochromocytoma are recommended.
Negative (No mutation detected)
No evidence of MEN2B-associated RET mutation. However, if clinical suspicion is high, consider other genetic causes.
Variant of Uncertain Significance (VUS)
A genetic variant was found but its clinical significance is unknown. Further family studies may help clarify.
Consult an oncologist or clinical geneticist if you have symptoms suggestive of MEN2B, a family history of the condition, or if you have been diagnosed with medullary thyroid carcinoma at a young age.
Limitations
- ⚠This test detects mutations in the RET gene only; other genes associated with MEN syndromes are not analyzed.
- ⚠Large deletions/duplications may not be detected by standard NGS; additional testing may be required.
- ⚠Variant of uncertain significance (VUS) may require further family studies.
- ⚠Test does not assess somatic mutations in tumor tissue.
Risks & Considerations
- ●Minimal risk of bruising or infection at the blood draw site
- ●Psychological impact of genetic testing results
- ●Potential for incidental findings
Interfering Factors
- ●Poor quality or degraded DNA sample
- ●Contamination during sample collection
- ●Insufficient DNA quantity
- ●Recent blood transfusion (may dilute DNA)
Compare With Similar Tests
| Test | RET Gene Multiple endocrine neoplasia type 2B NGS Genetic Test | RET Gene Single Site Analysis | MEN2 Panel (RET, NTRK1) | Whole Exome Sequencing |
|---|---|---|---|---|
| Comparison | RET Gene Multiple endocrine neoplasia type 2B NGS Genetic Test |
Frequently Asked Questions
What is the cost of the RET Gene MEN2B NGS Genetic Test?
What sample is required for this test?
Is fasting required before the test?
How long does it take to get the results?
What does the test detect?
Will I receive raw data files?
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Who should consider this test?
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Can this test be done during pregnancy?
What is the difference between MEN2A and MEN2B?
Does a negative result rule out MEN2B?
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