RET Gene RET, selective sequencing of exons 5, 8, 10, 11 and 13-16 NGS Genetic Test
Short Name: RET Gene Selective Sequencing
Also known as: RET Gene Mutation Analysis, RET Exon 5,8,10,11,13-16 Sequencing, RET NGS Panel
RET Gene RET, selective sequencing of exons 5, 8, 10, 11 and 13-16 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are typically delivered within 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify pathogenic variants in the RET gene that predispose individuals to hereditary cancer syndromes, particularly MEN2 and familial MTC. It aids in confirming clinical diagnoses, guiding prophylactic thyroidectomy decisions, and enabling cascade screening of at-risk family members.
- Test Code
- 6021
- CPT Code
- 81479
- ICD Code
- Z13.89
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are typically delivered within 3 to 4 weeks after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation is required. However, a genetic counseling session is recommended to discuss the implications of the test. Please bring any relevant medical records and family history information.
Method: Venipuncture or Fingerstick
Laboratory Analysis
A blood sample will be drawn from a vein in your arm. If using FTA card, a fingerstick blood drop will be collected. The procedure is quick and minimally invasive.
Report Delivery
You can resume normal activities immediately. There are no restrictions. The sample will be sent to the laboratory for analysis.
Timeline: Reports are typically delivered within 3 to 4 weeks after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify pathogenic variants in the RET gene that predispose individuals to hereditary cancer syndromes, particularly MEN2 and familial MTC. It aids in confirming clinical diagnoses, guiding prophylactic thyroidectomy decisions, and enabling cascade screening of at-risk family members.
How to Prepare
- Ensure the sample is collected in an EDTA vacutainer or on an FTA card as provided.
- Label the sample with patient's full name, date of birth, and collection date.
- If using FTA card, allow the blood spot to air dry completely before sealing.
- Transport the sample at ambient temperature; avoid extreme heat or cold.
- For extracted DNA, provide at least 1 µg of high-quality DNA in a sterile tube.
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"RET gene mutations are critical in hereditary cancer syndromes. Early detection through targeted sequencing enables proactive management and family screening."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Improperly labeled sample
- Sample exposed to extreme temperatures
- Sample received after prolonged transit time (>7 days) without proper storage
Understanding Your Results
No pathogenic variant detected
No mutation found in the analyzed exons. However, this does not rule out mutations in other regions or non-genetic causes.
Clinical recommendation: Consider further testing if clinical suspicion remains high.
Pathogenic variant detected
A disease-causing mutation is present. This confirms the genetic basis of the condition.
Clinical recommendation: Proceed with clinical management, including prophylactic surgery if indicated, and offer family screening.
Variant of uncertain significance (VUS)
A genetic variant was found, but its impact on health is not yet known.
Clinical recommendation: Further segregation analysis and functional studies may be needed. Genetic counseling is advised.
Consult your doctor if you have symptoms suggestive of MEN2, MTC, or pheochromocytoma, such as neck mass, hoarseness, difficulty swallowing, high blood pressure, or family history of these conditions. Early genetic testing can guide preventive measures.
Limitations
- ⚠This test only covers exons 5, 8, 10, 11, and 13-16; mutations in other exons or regulatory regions will not be detected.
- ⚠Large deletions/duplications may not be identified by sequencing alone.
- ⚠Variant interpretation may be limited by current knowledge; variants of uncertain significance may be reported.
- ⚠Not a substitute for full gene sequencing or whole exome sequencing.
- ⚠Results should be interpreted in the context of clinical and family history.
Risks & Considerations
- ●Minimal risk of bruising or infection at the blood draw site
- ●Psychological impact of learning genetic risk
- ●Potential for incidental findings
- ●Insurance or employment discrimination concerns (mitigated by laws in some regions)
Interfering Factors
- ●Contamination of sample with foreign DNA
- ●Degraded DNA due to improper storage or transport
- ●Presence of hematologic malignancies causing clonal hematopoiesis
- ●Recent blood transfusion (for blood samples)
- ●Insufficient DNA quantity or quality
Compare With Similar Tests
| Test | RET Gene RET, selective sequencing of exons 5, 8, 10, 11 and 13-16 NGS Genetic Test | Full RET Gene Sequencing | RET Gene Deletion/Duplication Analysis | Multi-Gene Cancer Panel |
|---|---|---|---|---|
| Comparison | RET Gene RET, selective sequencing of exons 5, 8, 10, 11 and 13-16 NGS Genetic Test |
Frequently Asked Questions
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