RUNX1-RUNX1T1 (AML1- ETO) t(8;21) Qualitative Test
Short Name: RUNX1-RUNX1T1 Qualitative
Also known as: AML1-ETO t(8;21) Qualitative Test, RUNX1-RUNX1T1 Translocation Test
RUNX1-RUNX1T1 (AML1- ETO) t(8;21) Qualitative Test test available at DNA Labs India for ₹4,500. Uses Real Time PCR on Bone marrow / Peripheral blood samples. Results in 3-4 days. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the RUNX1-RUNX1T1 (AML1-ETO) t(8;21) qualitative test is to detect the presence of the RUNX1-RUNX1T1 fusion gene in patients suspected of having Acute Myeloid Leukemia (AML). This genetic alteration is a key diagnostic and prognostic marker, helping to confirm AML subtype, guide treatment decisions such as targeted therapy, and monitor minimal residual disease. The test is essential for accurate diagnosis and personalized management of AML.
- Test Code
- 3192
- Price
- ₹4,500
- Sample Type
- Bone marrow / Peripheral blood
- Result Time
- 3-4 days
- Fasting Required
- No
- Method
- Real Time PCR
Sample Collection
Inform your doctor about any medications or supplements you are taking. Ensure a doctor's prescription is available, except for surgery, pregnancy, or travel abroad cases.
Method: Venipuncture for peripheral blood, bone marrow aspiration
Laboratory Analysis
Sample collection is performed by a trained healthcare professional using sterile techniques for bone marrow aspiration or venipuncture.
Report Delivery
Apply pressure to the collection site to prevent bleeding. Monitor for any signs of infection or discomfort and follow post-procedure care instructions.
Timeline: 3-4 days
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the RUNX1-RUNX1T1 (AML1-ETO) t(8;21) qualitative test is to detect the presence of the RUNX1-RUNX1T1 fusion gene in patients suspected of having Acute Myeloid Leukemia (AML). This genetic alteration is a key diagnostic and prognostic marker, helping to confirm AML subtype, guide treatment decisions such as targeted therapy, and monitor minimal residual disease. The test is essential for accurate diagnosis and personalized management of AML.
How to Prepare
- Use sterile EDTA vacutainer for sample collection
- Transport the sample immediately with a cool pack to maintain stability
- Label the sample correctly with patient details
- Avoid hemolysis during blood collection
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This qualitative test is essential for identifying the specific genetic alteration in AML, which can influence treatment strategies and prognosis."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted sample
- Incorrect sample container or insufficient volume
- Sample not transported under proper conditions
Understanding Your Results
Detected
Presence of RUNX1-RUNX1T1 fusion gene, confirming AML with t(8;21) translocation. This subtype may have specific treatment implications and prognosis.
Not Detected
No RUNX1-RUNX1T1 fusion gene detected. However, clinical correlation with other tests is recommended, as AML may have other genetic alterations.
Consult a hematologist or oncologist if you experience symptoms of AML such as persistent fever, fatigue, or unexplained bleeding, or if test results are abnormal for further evaluation and management.
Limitations
- ⚠This is a qualitative test and does not quantify the level of fusion gene
- ⚠May not detect low levels of the translocation if below the assay's sensitivity
- ⚠Results should be correlated with clinical findings and other diagnostic tests
Risks & Considerations
- ●Minor pain or bruising at the sample collection site
- ●Rare risk of infection at the bone marrow aspiration site
- ●Minimal discomfort during the procedure
Interfering Factors
- ●Sample contamination during collection or transport
- ●Improper storage or handling of the sample
- ●Presence of inhibitors in the sample affecting PCR amplification
Compare With Similar Tests
| Test | RUNX1-RUNX1T1 (AML1- ETO) t(8;21) Qualitative | FLT3 Mutation Analysis | NPM1 Mutation Test | CBFβ-MYH11 Translocation Test | Karyotyping for AML |
|---|---|---|---|---|---|
| Comparison | RUNX1-RUNX1T1 (AML1- ETO) t(8;21) Qualitative | Detects FLT3 mutations in AML, which are common and influence treatment response. | Identifies NPM1 mutations, another frequent genetic alteration in AML with prognostic value. | Detects inv(16) or t(16;16) translocation, associated with a different AML subtype. | Provides a broad view of chromosomal abnormalities but may be less specific than targeted PCR tests. |
Frequently Asked Questions
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