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SDHB Gene Paragangliomas type 4 NGS Genetic Test

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SDHB Gene Paragangliomas type 4 NGS Genetic Test

Short Name: SDHB Paraganglioma Type 4 Test

Also known as: SDHB Gene Test, Paraganglioma Type 4 Genetic Test, SDHB Mutation Analysis

SDHB Gene Paragangliomas type 4 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the SDHB gene that cause paragangliomas type 4, aiding in diagnosis, risk assessment, and management of the condition.

Test Code
2921
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation required. Inform the lab about any medications or recent transfusions.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in your arm.

Step 3

Report Delivery

Apply pressure to the puncture site to stop bleeding. Resume normal activities.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling session to discuss family history and test implications.
2
During the Test:Sample collection and analysis in the laboratory using NGS technology.
3
After the Test:Receive report and follow-up with genetic counseling for result interpretation.

About This Test

Who Should Get This Test

To identify mutations in the SDHB gene that cause paragangliomas type 4, aiding in diagnosis, risk assessment, and management of the condition.

How to Prepare

  • No fasting required for this test
  • Bring identification and doctor's prescription
  • Wear loose clothing for easy access to arm

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for SDHB mutations is crucial for early detection and management of paragangliomas, especially in families with a history of the condition."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5-10 ml blood
ContainerEDTA tube or FTA card
Collection MethodVenipuncture

Sample Stability

Blood sample stable at room temperature for 24 hours
Extracted DNA stable for longer periods when stored properly
Sample Rejection Criteria:
  • Hemolyzed or insufficient sample
  • Incorrect labeling
  • Sample not stored properly

Understanding Your Results

Genetic test results indicate the presence or absence of mutations in the SDHB gene. A positive result means a mutation was found, which may increase the risk of paragangliomas. A negative result means no mutation was detected, but does not completely rule out risk.
Positive result: Consult a geneticist for further management and family screening
Negative result: Discuss with doctor about other possible causes
Variant of uncertain significance: May require additional testing or monitoring
⚠️ When to Consult a Doctor:

If you have a family history of paragangliomas, experience symptoms, or receive a positive genetic test result, consult a geneticist or oncologist immediately.

Limitations

  • ⚠May not detect all types of mutations
  • ⚠Results require genetic counseling for interpretation
  • ⚠Not a standalone diagnostic tool; clinical correlation needed

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Poor sample quality
  • ●Contamination
  • ●Recent blood transfusion

Compare With Similar Tests

TestSDHB Gene Paragangliomas type 4 NGS Genetic TestSDHD Gene TestSDHC Gene TestVHL Gene Test
ComparisonSDHB Gene Paragangliomas type 4 NGS Genetic Test

Frequently Asked Questions

What is the SDHB Gene Paragangliomas Type 4 NGS Genetic Test?
It is a genetic test that uses Next Generation Sequencing to detect mutations in the SDHB gene, which are linked to paragangliomas type 4, a rare tumor of the nervous system.
Who should consider getting this test?
Individuals with a family history of paragangliomas, symptoms like abdominal pain or high blood pressure, or those diagnosed with paraganglioma should consider this test.
What are the symptoms of SDHB gene paragangliomas type 4?
Common symptoms include abdominal pain, nausea, vomiting, high blood pressure, heart palpitations, headaches, anxiety, and weight loss.
How is the test performed?
A blood or saliva sample is collected and analyzed using NGS technology to identify mutations in the SDHB gene.
What is the cost of the SDHB Gene Paragangliomas Type 4 NGS Genetic Test?
The cost is INR 20,000 at DNA Labs India, with free home sample collection available across India.
Is the test covered by insurance?
This test may not be covered by insurance. It is advisable to check with your insurance provider before proceeding.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What do the results mean?
A positive result indicates a mutation in the SDHB gene, increasing risk for paragangliomas. A negative result means no mutation was detected, but does not eliminate all risk.
Is genetic counseling provided with the test?
Yes, DNA Labs India includes a genetic counseling session to help interpret results and discuss implications.
Can the test be done at home?
Yes, free home sample collection is available for online bookings in many cities across India.
What is the accuracy of the test?
The test uses advanced NGS technology with high accuracy, but results should be correlated with clinical findings.
What should I do if I test positive?
Consult a geneticist or oncologist immediately for further management, family screening, and personalized treatment options.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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