Sirolimus (Rapamycin) Test
Short Name: Sirolimus Test
Also known as: Rapamycin Test, Sirolimus Whole Blood Test, Sirolimus Trough Level
Sirolimus (Rapamycin) Test test available at DNA Labs India for ₹6,500. Uses LC-MS/MS on Whole Blood samples. Results in The report is delivered the same day if the sample is received by 5 pm.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Ramarao Paidisetty
Consultant Biochemist · Reg: 21504
Last reviewed: September 7, 2026
Overview
The purpose of the Sirolimus (Rapamycin) Test is to measure the trough level of sirolimus in the blood to maintain it within the therapeutic window, assess patient compliance, and adjust dosage to prevent organ rejection while minimizing toxicity.
- Test Code
- 3638
- Price
- ₹6,500
- Sample Type
- Whole Blood
- Result Time
- The report is delivered the same day if the sample is received by 5 pm.
- Fasting Required
- No
- Method
- LC-MS/MS
Sample Collection
Ideal sampling time is 1 hour before the next dose (12-hour trough). Provide the date and time of sampling, amount and time of the last dose. Inform your doctor about all medications, including over-the-counter and herbal supplements.
Method: Venipuncture
Laboratory Analysis
Standard venipuncture is performed; no special precautions are required.
Report Delivery
You may resume normal activities. Refrigerate the sample if there is any delay in shipping; do not freeze.
Timeline: The report is delivered the same day if the sample is received by 5 pm.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Sirolimus (Rapamycin) Test is to measure the trough level of sirolimus in the blood to maintain it within the therapeutic window, assess patient compliance, and adjust dosage to prevent organ rejection while minimizing toxicity.
How to Prepare
- Collect 3 mL whole blood in a Lavender Top (EDTA) tube.
- Ship refrigerated; do not freeze.
- Sample ideally at 1 hour before the next dose (12-hour trough).
Doctor's Notes
Reviewed by Dr Ramarao Paidisetty — MBBS, MD (Biochemistry) · Reg. No. 21504
"Sirolimus has a narrow therapeutic index. Regular trough monitoring is essential to balance efficacy against toxicity, especially in renal transplant recipients on concurrent immunosuppressants."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or haemolysed sample
- Improper sample container
- Sample received frozen
- Missing date and time of last dose
Understanding Your Results
Action: Assess adherence, consider dose adjustment, monitor for signs of rejection.
Level: Subtherapeutic (<4 ng/mL)
Action: Maintain the current dose and schedule follow-up as clinically indicated.
Level: Therapeutic (4-20 ng/mL)
Action: Risk of toxicity; reduce dose and monitor for adverse effects such as renal dysfunction or infection.
Level: Supratherapeutic (>20 ng/mL)
Consult your treating physician immediately if you experience ankle/feet/hand swelling, shortness of breath, chest pain, dizziness, confusion, seizures, or unusual bleeding or bruising after starting sirolimus.
Limitations
- ⚠Results should be interpreted only in conjunction with clinical findings and other laboratory tests.
- ⚠The test does not directly measure immunosuppressive effect; clinical correlation is required.
Risks & Considerations
- ●Minimal risk of slight bruising or dizziness at the puncture site.
- ●Rare risk of infection or prolonged bleeding.
Interfering Factors
- ●Co-administration of CYP3A4 inhibitors or inducers may alter sirolimus levels.
- ●Improper sampling time relative to the last dose can lead to erroneous results.
Frequently Asked Questions
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