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SMARCE1 Gene Meningioma, familial, susceptibility to NGS Genetic Test

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SMARCE1 Gene Meningioma, familial, susceptibility to NGS Genetic Test

Short Name: SMARCE1 Meningioma NGS Test

Also known as: SMARCE1 meningioma genetic test, Familial meningioma susceptibility test, SMARCE1 gene mutation analysis

SMARCE1 Gene Meningioma, familial, susceptibility to NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the SMARCE1 gene for early detection, diagnosis, and management of familial meningioma susceptibility, enabling informed medical decisions and family planning.

Test Code
2897
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

No specific preparation required. Provide clinical history and family pedigree chart as advised.

Method: Venipuncture or DNA extraction

Step 2

Laboratory Analysis

Blood sample will be drawn by a trained phlebotomist. For DNA extraction, follow lab instructions.

Step 3

Report Delivery

Apply pressure to the puncture site. Resume normal activities. Store samples as per instructions if self-collected.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Provide detailed clinical history and family pedigree. No fasting required.
2
During the Test:Sample collection via blood draw or DNA extraction. Procedure is minimally invasive.
3
After the Test:Results available in 3-4 weeks. Follow up with genetic counseling for interpretation.

About This Test

Who Should Get This Test

To identify mutations in the SMARCE1 gene for early detection, diagnosis, and management of familial meningioma susceptibility, enabling informed medical decisions and family planning.

How to Prepare

  • Use sterile equipment
  • Label samples correctly
  • Transport at ambient temperature unless specified

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for SMARCE1 mutations is crucial for early detection and management of familial meningioma, especially in individuals with a family history or symptoms."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture or DNA extraction

Sample Stability

Blood: 24-48 hours at room temperature
Extracted DNA: Stable for longer periods as per lab protocol
Sample Rejection Criteria:
  • Hemolyzed samples
  • Insufficient volume
  • Improper labeling

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the SMARCE1 gene. Genetic counseling is recommended for interpretation.
📊

Positive for pathogenic variant

Increased risk for familial meningioma. Clinical correlation and family screening advised.

📊

Negative for pathogenic variant

No mutation detected. Risk may not be eliminated; consider other genetic or environmental factors.

📊

Variant of uncertain significance

Further testing or family studies may be needed for clarification.

⚠️ When to Consult a Doctor:

Consult a healthcare professional if you have a family history of meningioma, experience symptoms like headaches or seizures, or receive a positive test result for further management and genetic counseling.

Limitations

  • ⚠May not detect all genetic variants or mutations
  • ⚠Results require clinical correlation
  • ⚠Does not replace imaging or other diagnostic methods

Risks & Considerations

  • ●Minimal risks from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Poor sample quality
  • ●Contaminated DNA
  • ●Recent blood transfusions

Frequently Asked Questions

What is SMARCE1 gene meningioma?
It is a rare familial meningioma caused by mutations in the SMARCE1 gene, leading to increased susceptibility to tumors from the meninges.
How is the NGS genetic test performed?
The test uses Next-Generation Sequencing to analyze DNA from blood or extracted samples for mutations in the SMARCE1 gene.
What is the cost of the SMARCE1 gene meningioma NGS test in India?
The cost is approximately INR 20,000 at DNA Labs India, with possible variations based on location and testing scope.
Is home sample collection available?
Yes, free home sample collection is offered for online bookings across India.
How long does it take to get results?
Results are typically available in 3 to 4 weeks after sample collection.
What are the symptoms of SMARCE1 gene meningioma?
Symptoms include headaches, seizures, memory loss, difficulty concentrating, weakness or numbness in limbs, and vision problems.
Is the test covered by insurance?
Coverage depends on the insurance provider and policy. Check with your insurer for details.
Can children undergo this genetic test?
Yes, the test is applicable to all ages, but genetic counseling is recommended for minors.
What if the test result is positive?
A positive result indicates increased risk for familial meningioma. Consult a healthcare professional for management and family screening.
How accurate is NGS testing for SMARCE1 mutations?
NGS is highly accurate for detecting genetic variants, but results should be interpreted in clinical context.
Do I need a doctor's referral for this test?
A referral is recommended, but you can book directly through DNA Labs India with clinical history provided.
What is the inheritance pattern of SMARCE1 gene meningioma?
It follows an autosomal dominant pattern, meaning one mutated copy from a parent can increase risk.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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