SRGAP1 Gene Thyroid cancer type 2, nonmedullary, susceptibility to NGS Genetic Test
Short Name: SRGAP1 NGS Thyroid Cancer Susceptibility
Also known as: SRGAP1 Gene Mutation Test, Thyroid Cancer Susceptibility NGS Panel, NMTC2 Genetic Screening
SRGAP1 Gene Thyroid cancer type 2, nonmedullary, susceptibility to NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Results are usually delivered within 3 to 4 weeks after the sample reaches the laboratory. You will be notified via email or SMS when the report is ready.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of this NGS genetic test is to detect mutations in the SRGAP1 gene that are associated with an increased susceptibility to nonmedullary thyroid cancer type 2 (NMTC2). By identifying these genetic variants, the test helps in early diagnosis, risk assessment, and guiding clinical management. It also aids in genetic counseling for family members who may be at risk.
- Test Code
- 6024
- CPT Code
- 81479
- ICD Code
- Z15.09
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Results are usually delivered within 3 to 4 weeks after the sample reaches the laboratory. You will be notified via email or SMS when the report is ready.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation required. However, a genetic counseling session is recommended before the test to discuss implications. Please inform your doctor about any medications or supplements you are taking.
Method: Venipuncture or Fingerstick
Laboratory Analysis
Blood sample will be collected by a trained phlebotomist. For FTA card, a simple fingerstick is sufficient. The procedure is quick and minimally invasive.
Report Delivery
No specific precautions. You can resume normal activities immediately. The sample will be sent to the laboratory for analysis.
Timeline: Results are usually delivered within 3 to 4 weeks after the sample reaches the laboratory. You will be notified via email or SMS when the report is ready.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this NGS genetic test is to detect mutations in the SRGAP1 gene that are associated with an increased susceptibility to nonmedullary thyroid cancer type 2 (NMTC2). By identifying these genetic variants, the test helps in early diagnosis, risk assessment, and guiding clinical management. It also aids in genetic counseling for family members who may be at risk.
How to Prepare
- Ensure the sample is collected in the provided EDTA tube or on the FTA card.
- Label the sample with your name, date of birth, and collection date.
- If using FTA card, allow the blood spot to air dry completely before sealing.
- Store the sample at room temperature (15-30°C) until shipment.
- Avoid hemolysis or clotting of blood sample.
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"Genetic testing for SRGAP1 mutations is crucial for early risk assessment in families with nonmedullary thyroid cancer. NGS provides comprehensive analysis to guide surveillance and preventive strategies."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Sample received after prolonged transit time (>7 days)
- Improper labeling or missing patient information
- Sample contaminated or leaked
Understanding Your Results
Negative
No pathogenic variants detected in the SRGAP1 gene. This reduces the likelihood of hereditary NMTC2 due to SRGAP1, but does not exclude other genetic causes.
Positive
A pathogenic or likely pathogenic variant was identified. This indicates an increased risk for developing nonmedullary thyroid cancer type 2. Genetic counseling and enhanced surveillance are recommended.
Variant of Uncertain Significance (VUS)
A genetic variant was found, but its clinical significance is not yet known. Further testing of family members may help clarify the variant's role.
If you have a family history of thyroid cancer, especially nonmedullary type, or if you have symptoms such as a neck lump, difficulty swallowing, or hoarseness, consult your doctor. A positive genetic test result should be discussed with an oncologist or genetic counselor to plan appropriate surveillance and preventive measures.
Limitations
- ⚠This test only analyzes the SRGAP1 gene; other genes associated with thyroid cancer are not covered.
- ⚠Variant of uncertain significance (VUS) may be reported; further family studies may be needed.
- ⚠This test does not detect large deletions/duplications or epigenetic changes.
- ⚠Negative result does not rule out hereditary cancer risk due to other genes.
- ⚠Clinical correlation is essential; genetic testing is not a substitute for medical evaluation.
Risks & Considerations
- ●No significant physical risks associated with blood draw
- ●Possible bruising or infection at the puncture site (rare)
- ●Psychological impact of learning genetic risk
- ●Potential for incidental findings (unrelated genetic variants)
Interfering Factors
- ●Contamination of sample with foreign DNA
- ●Insufficient DNA quantity or quality
- ●Presence of hematologic malignancies causing clonal hematopoiesis
- ●Recent blood transfusion (within 2 weeks)
- ●Bone marrow transplantation
Compare With Similar Tests
| Test | SRGAP1 Gene Thyroid cancer type 2, nonmedullary, susceptibility to NGS Genetic Test | RET Gene Mutation Analysis | Comprehensive Thyroid Cancer Panel |
|---|---|---|---|
| Comparison | SRGAP1 Gene Thyroid cancer type 2, nonmedullary, susceptibility to NGS Genetic Test |
Frequently Asked Questions
What is the SRGAP1 gene?
What is nonmedullary thyroid cancer type 2 (NMTC2)?
Who should consider this genetic test?
What is the cost of the SRGAP1 gene NGS test?
What sample is required for the test?
How long does it take to get results?
What does a positive result mean?
What does a negative result mean?
What is a variant of uncertain significance (VUS)?
Is genetic counseling included in the test?
Can this test be done during pregnancy?
Does DNA Labs India provide raw data files?
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