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t(11;19) (q23;p13.3) TCF3-BX1(E2A-PBX1) PCR Qualitative Test

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t(11;19) (q23;p13.3) TCF3-BX1(E2A-PBX1) PCR Qualitative Test

Short Name: TCF3-BX1 PCR Qualitative Test

Also known as: E2A-PBX1 Fusion Gene Test, TCF3-PBX1 PCR Test

t(11;19) (q23;p13.3) TCF3-BX1(E2A-PBX1) PCR Qualitative Test test available at DNA Labs India for ₹5,000. Uses Real Time PCR on Whole Blood or Bone Marrow samples. Results in Results available in 2-3 business days after sample receipt.. Free home collection in 300+ cities across India.

PCR Qualitative🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To detect the presence of the TCF3-BX1 fusion gene for the diagnosis and management of leukemia and lymphoma.

Test Code
1421
Price
₹5,000
Sample Type
Whole Blood or Bone Marrow
Result Time
Results available in 2-3 business days after sample receipt.
Fasting Required
No
Method
Real Time PCR
Step 1

Sample Collection

Provide detailed clinical history including symptoms, family history, and current medications. No fasting required.

Method: Venipuncture or Bone Marrow Aspiration

Step 2

Laboratory Analysis

Collection by trained phlebotomist or hematologist using sterile techniques.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent hematoma. Monitor for signs of infection.

Timeline: Results available in 2-3 business days after sample receipt.

Patient Instructions

1
Before the Test:No special preparation needed. Ensure clinical history is provided.
2
During the Test:Sample collection as per standard protocol.
3
After the Test:Normal activities can be resumed immediately. Follow-up on results with healthcare provider.

About This Test

Who Should Get This Test

To detect the presence of the TCF3-BX1 fusion gene for the diagnosis and management of leukemia and lymphoma.

How to Prepare

  • Use lavender top EDTA tube for blood
  • For bone marrow, use appropriate anticoagulant
  • Ship sample refrigerated at 2-8°C
  • Do not freeze the sample
  • Label tube with patient details and clinical history

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"The TCF3-BX1 PCR test is vital for identifying genetic markers that inform personalized treatment plans for leukemia patients."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole Blood or Bone Marrow
Sample Volume3 mL (2 mL min.)
ContainerLavender Top (EDTA) Tube
Collection MethodVenipuncture or Bone Marrow Aspiration

Sample Stability

Room Temperature: Stable for 6 hours
Refrigerated (2-8°C): Stable for 72 hours
Frozen: Not recommended
Sample Rejection Criteria:
  • Sample hemolyzed or clotted
  • Insufficient sample volume
  • Improperly labeled or contaminated container
  • Sample received frozen

Understanding Your Results

The TCF3-BX1 PCR Qualitative Test results indicate whether the fusion gene is present, which is critical for diagnosing associated leukemias.
📊

Positive

Detection of TCF3-BX1 fusion gene. Highly suggestive of leukemia or lymphoma. Further confirmatory testing and clinical evaluation recommended.

📊

Negative

No TCF3-BX1 fusion gene detected. Does not completely rule out cancer; clinical correlation with other tests advised.

⚠️ When to Consult a Doctor:

Consult an oncologist or hematologist if symptoms persist, worsen, or if test results are positive for further evaluation and management.

Limitations

  • ⚠Qualitative detection only; does not measure fusion gene quantity
  • ⚠May not detect low-level mutations below detection limit
  • ⚠False negatives possible in samples with low tumor burden

Risks & Considerations

  • ●Minor pain or bruising at the needle site
  • ●Rare risk of infection
  • ●Potential for false positive or negative results

Interfering Factors

  • ●Hemolyzed or lipemic samples
  • ●Sample contamination
  • ●Previous blood transfusions within 4 weeks

Frequently Asked Questions

What is the TCF3-BX1 fusion gene?
The TCF3-BX1 fusion gene is formed by the translocation between chromosomes 11 and 19, involving the TCF3 and PBX1 genes. This abnormality is linked to certain types of leukemia.
Why is the TCF3-BX1 PCR test important?
It helps in diagnosing leukemia, guiding treatment decisions, and monitoring disease progression by detecting the specific genetic fusion.
How is the test performed?
The test uses real-time PCR technology on a blood or bone marrow sample to detect the presence of the TCF3-BX1 fusion gene.
What sample is required for the test?
A 3 mL whole blood sample in an EDTA tube or a bone marrow aspirate is required.
Is fasting required before the test?
No, fasting is not required. However, providing clinical history is mandatory.
How long does it take to get results?
Results are typically available within 2-3 business days after the sample is received at the laboratory.
What does a positive result mean?
A positive result indicates the presence of the TCF3-BX1 fusion gene, which is associated with leukemia or lymphoma. Further consultation with an oncologist is recommended.
What does a negative result mean?
A negative result means the fusion gene was not detected. However, it does not rule out cancer entirely, and clinical evaluation should continue if symptoms persist.
Are there any risks associated with the test?
The risks are minimal and similar to a standard blood draw, such as slight pain or bruising at the collection site.
How much does the TCF3-BX1 PCR test cost?
The cost of the test at DNA Labs India is INR 5000, which includes the test and genetic counseling consultation.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
Who should take this test?
Individuals with symptoms of leukemia such as fatigue, fever, night sweats, weight loss, or swollen lymph nodes, or those diagnosed with ALL for genetic characterization.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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