VKORC1 Gene Coumarin resistance NGS Genetic Test
Short Name: VKORC1 Coumarin Resistance Test
Also known as: VKORC1 Mutation Test, Warfarin Resistance Genetic Test, Coumarin Sensitivity Test
VKORC1 Gene Coumarin resistance NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To diagnose genetic variations in the VKORC1 gene that may cause resistance to coumarin-based medications, enabling personalized treatment plans to avoid adverse reactions and optimize therapy.
- Test Code
- 1954
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
Clinical history review and genetic counseling session to draw a pedigree chart of family members affected with coumarin resistance.
Method: Venipuncture or FTA Card Collection
Laboratory Analysis
Standard blood draw via venipuncture or application of one drop of blood on an FTA card.
Report Delivery
Sample is sent to the lab for processing. Results are delivered in 3 to 4 weeks.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
To diagnose genetic variations in the VKORC1 gene that may cause resistance to coumarin-based medications, enabling personalized treatment plans to avoid adverse reactions and optimize therapy.
How to Prepare
- Provide complete clinical history of the patient
- Undergo genetic counseling session before testing
- Ensure sample is collected in a sterile environment
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for VKORC1 variations can guide personalized dosing of coumarin medications, reducing bleeding risks and improving therapeutic outcomes for patients."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Incorrectly labeled or unlabeled samples
Understanding Your Results
No Variant Detected
Normal response to coumarin medications expected. Standard dosing may be appropriate.
Action: Consult with your doctor for personalized treatment.
Heterozygous Variant Detected
Possible reduced sensitivity to coumarin medications. May require higher doses.
Action: Discuss adjusted dosing with your healthcare provider.
Homozygous Variant Detected
High resistance to coumarin medications. Significant dose adjustments or alternative therapies may be needed.
Action: Seek genetic counseling and consider alternative treatments.
If you experience symptoms of bleeding, adverse reactions to coumarin medications, or have a family history of coumarin resistance, consult your doctor immediately.
Limitations
- ⚠Test may not detect all possible genetic variants
- ⚠Results require interpretation by a genetic counselor
- ⚠Does not replace clinical evaluation for bleeding disorders
Risks & Considerations
- ●Minimal risk of bruising or infection at the blood draw site
- ●No significant risks associated with genetic testing itself
Interfering Factors
- ●Sample contamination during collection or transport
- ●Improper storage of blood or DNA sample
- ●Recent blood transfusions may affect DNA analysis
Frequently Asked Questions
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Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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