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Von Willebrand Factor Collagen Binding Activity (vWF) Test

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Von Willebrand Factor Collagen Binding Activity (vWF) Test

Short Name: vWF:CB Test

Also known as: vWF:CB, Von Willebrand Factor Collagen Binding Activity, Collagen Binding Assay

Von Willebrand Factor Collagen Binding Activity (vWF) Test test available at DNA Labs India for ₹13,000. Uses Chemiluminescent Immunoassay (CLIA) on Whole Blood samples. Results in If your sample is received by 11 am, the report will be delivered the same day by 6 pm via online portal, email, or WhatsApp.. Free home collection in 300+ cities across India.

Hematology🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The vWF:CB test is used to diagnose von Willebrand disease, a bleeding disorder. It measures the ability of von Willebrand factor to bind to collagen, which reflects the functional activity of the protein. It is a supplemental assay to factor VIII activity, vWF:Ag, and vWF:RCo assays in typing of VWD.

Test Code
3752
Price
₹13,000
Sample Type
Whole Blood
Result Time
If your sample is received by 11 am, the report will be delivered the same day by 6 pm via online portal, email, or WhatsApp.
Fasting Required
No
Method
Chemiluminescent Immunoassay (CLIA)
Step 1

Sample Collection

Overnight fasting is preferred, though not mandatory. Inform your doctor about any medications you are taking. A duly filled Coagulation Requisition Form (Form 15) is mandatory.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample is drawn from a vein in your arm. The blood must be mixed thoroughly by inversion in the blue top (sodium citrate) tube to ensure proper anticoagulation.

Step 3

Report Delivery

No specific precautions are required after the test. You may experience minor bruising at the puncture site, which is normal.

Timeline: If your sample is received by 11 am, the report will be delivered the same day by 6 pm via online portal, email, or WhatsApp.

Patient Instructions

1
Before the Test:Overnight fasting is preferred. Complete the Coagulation Requisition Form (Form 15). Inform your doctor about all medications and supplements.
2
During the Test:A small amount of blood is drawn from a vein. Ensure the collection tube is inverted gently to mix with the anticoagulant.
3
After the Test:Resume normal activities immediately. A tight bandage may be applied to prevent bruising.

About This Test

Who Should Get This Test

The vWF:CB test is used to diagnose von Willebrand disease, a bleeding disorder. It measures the ability of von Willebrand factor to bind to collagen, which reflects the functional activity of the protein. It is a supplemental assay to factor VIII activity, vWF:Ag, and vWF:RCo assays in typing of VWD.

How to Prepare

  • Collect 3 mL whole blood in 1 Blue Top (Sodium Citrate) tube.
  • Mix thoroughly by inversion.
  • Transport to lab within 4 hours at room temperature.
  • If transport is delayed, prepare PPP within 1 hour of collection by double centrifugation at 3600 rpm for 15 minutes.
  • Transfer PPP to a clean plastic screw-capped vial, label it, and freeze immediately.
  • Ship frozen. Do not thaw.
  • Overnight fasting is preferred.
  • Duly filled Coagulation Requisition Form (Form 15) is mandatory.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole Blood
Sample Volume3 mL
ContainerBlue Top (Sodium Citrate) tube
Collection MethodVenipuncture

Sample Stability

Room Temperature: 4 hours
Refrigerator: 4 hours
Frozen: 2 weeks
Sample Rejection Criteria:
  • Clotted sample
  • Hemolyzed sample
  • Improper labeling
  • Sample not transported or processed within the specified time
  • Delayed shipment without freezing

Understanding Your Results

Results of the vWF:CB test should be interpreted in conjunction with other vWF assays and clinical findings.
Low vWF:CB with normal vWF:Ag suggests a functional defect of von Willebrand factor, such as VWD type 2A or 2B.
Reduced vWF:CB with reduced vWF:Ag is seen in type 1 or type 3 VWD.
Normal vWF:CB with reduced vWF:Ag may indicate a quantitative deficiency without functional abnormality, as in VWD type 2M.
vWF:CB specifically helps distinguish VWD types 2A and 2B from type 2M due to its sensitivity to high-molecular-weight multimers.
⚠️ When to Consult a Doctor:

Consult a doctor if you experience easy bruising, prolonged nosebleeds, heavy menstrual bleeding, or any unexplained bleeding. A hematologist can guide you on appropriate testing and management.

Limitations

  • ⚠vWF:CB alone is not sufficient to diagnose von Willebrand disease; results should be interpreted with vWF:Ag, vWF:RCo, and Factor VIII activity.
  • ⚠Low results may be seen in conditions other than VWD, such as low vWF levels due to blood group O.
  • ⚠Normal results do not exclude mild VWD.

Risks & Considerations

  • ●Minor pain or bruising at the puncture site
  • ●Uncommon: infection, excessive bleeding, or hematoma

Interfering Factors

  • ●Improper sample collection or handling, including freezing and thawing
  • ●Recent exercise or acute stress
  • ●Pregnancy and hormonal therapy
  • ●Presence of other coagulation inhibitors

Frequently Asked Questions

What is the Von Willebrand Factor Collagen Binding Activity (vWF:CB) test?
The vWF:CB test measures how effectively von Willebrand factor binds to collagen, a key step in blood clotting. It helps diagnose von Willebrand disease.
Why is this test done?
It is done when a person has symptoms of excessive bleeding or a family history of von Willebrand disease. It also helps classify the type of VWD.
What symptoms of von Willebrand disease should you watch for?
Common symptoms include easy bruising, nosebleeds that are hard to stop, heavy menstrual periods, bleeding gums, and blood in urine or stool.
How is the blood sample collected for the vWF:CB test?
A 3 mL blood sample is collected from a vein in the arm into a blue top (sodium citrate) tube. The tube must be mixed thoroughly by inversion.
Is fasting necessary before the vWF:CB test?
Overnight fasting is preferred but not mandatory. You can drink water, but avoid food until the sample is collected for best results.
What is the cost of the vWF:CB test at DNA Labs India?
The special discounted price is INR 13,000, which includes free home sample collection in many cities across India.
How long will it take to get the report for the vWF:CB test?
If your sample is received by 11 am, the report will be delivered the same day by 6 pm via online portal, email, or WhatsApp.
What does a low vWF:CB result indicate?
A low result may indicate von Willebrand disease, particularly a functional defect involving high-molecular-weight multimers, such as type 2A or 2B.
Is home sample collection available for this test?
Yes, DNA Labs India provides free home sample collection for online bookings of the vWF:CB test in over 300 cities.
How is vWF:CB different from vWF:RCo?
vWF:CB measures the binding of vWF to collagen, while vWF:RCo measures its ability to induce platelet aggregation in the presence of ristocetin. Both are functional assays used together for VWD classification.
Can the vWF:CB test diagnose all types of von Willebrand disease?
It is not sufficient alone. It must be combined with vWF antigen, ristocetin cofactor activity, and factor VIII activity to accurately diagnose and classify VWD.
Are there any precautions after the vWF:CB test?
No specific precautions are needed. You can resume normal activities immediately. A small bruise at the puncture site is possible.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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