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XRCC3 Gene Melanoma, cutaneous malignant, familial type 6, susceptibility to NGS Genetic Test

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XRCC3 Gene Melanoma, cutaneous malignant, familial type 6, susceptibility to NGS Genetic Test

Short Name: XRCC3 Melanoma Genetic Test

Also known as: XRCC3 Gene Mutation Test, Familial Melanoma Genetic Test, Melanoma Susceptibility Test

XRCC3 Gene Melanoma, cutaneous malignant, familial type 6, susceptibility to NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS (Next-Generation Sequencing) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic TestAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To identify mutations in the XRCC3 gene that increase the risk of developing familial melanoma, enabling early intervention, personalized risk assessment, and tailored management plans.

Test Code
2892
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS (Next-Generation Sequencing)
Step 1

Sample Collection

No specific preparation required. Provide clinical history and family pedigree during genetic counseling.

Method: Venipuncture or Fingerstick

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or fingerstick. Ensure proper labeling and handling.

Step 3

Report Delivery

Apply pressure to the puncture site. Store sample as instructed for stability.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling session to discuss family history and draw a pedigree chart.
2
During the Test:Blood sample collection for DNA extraction and NGS analysis.
3
After the Test:Report generation and genetic counseling to explain results and implications.

About This Test

Who Should Get This Test

To identify mutations in the XRCC3 gene that increase the risk of developing familial melanoma, enabling early intervention, personalized risk assessment, and tailored management plans.

How to Prepare

  • Use sterile collection tubes
  • Label samples with patient details
  • Transport at ambient temperature unless specified
  • Avoid hemolysis during blood draw

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Genetic testing for XRCC3 mutations aids in early risk assessment and personalized management for individuals with a family history of melanoma."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL
ContainerEDTA Tube or FTA Card
Collection MethodVenipuncture or Fingerstick

Sample Stability

Blood in EDTA tube: stable for 7 days at 2-8°C
FTA Card: stable at room temperature for years
Sample Rejection Criteria:
  • Insufficient sample volume
  • Contaminated or hemolyzed samples
  • Improper labeling or documentation

Understanding Your Results

Results indicate the presence or absence of mutations in the XRCC3 gene. A positive result suggests increased genetic risk for melanoma, while a negative result indicates no detected mutations in this gene.
Positive: Pathogenic variant detected – higher risk for familial melanoma; recommend enhanced surveillance and genetic counseling.
Negative: No pathogenic variant detected – risk based on other factors; standard screening may apply.
Variant of Uncertain Significance (VUS): Clinical significance unknown; follow-up testing and monitoring advised.
⚠️ When to Consult a Doctor:

Consult a genetic counselor or oncologist if results are positive, if there is a family history of melanoma, or if symptoms of melanoma develop.

Limitations

  • ⚠Test only analyzes the XRCC3 gene; other genetic factors contributing to melanoma risk may not be detected
  • ⚠Results do not guarantee development or absence of melanoma
  • ⚠Variants of uncertain significance (VUS) may be reported, requiring further evaluation

Risks & Considerations

  • ●Minor bruising or discomfort at the blood draw site
  • ●Psychological impact of genetic risk information

Interfering Factors

  • ●Sample contamination during collection or processing
  • ●Degraded DNA due to improper storage
  • ●Recent blood transfusions may affect results

Frequently Asked Questions

What is the XRCC3 gene?
The XRCC3 gene provides instructions for a protein involved in DNA repair. Mutations can impair this function, increasing melanoma risk.
Who should consider this genetic test?
Individuals with a family history of melanoma, personal history of the disease, or symptoms suggesting melanoma.
How is the test performed?
Using NGS technology to analyze DNA from a blood sample for mutations in the XRCC3 gene.
What does a positive result mean?
It indicates a mutation in XRCC3, suggesting higher genetic risk for familial melanoma. Enhanced screening and prevention are recommended.
What does a negative result mean?
No pathogenic mutations were detected in XRCC3, but other genetic or environmental factors may still contribute to risk.
Is the test painful?
The test involves a standard blood draw, which may cause minor discomfort but is generally not painful.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What is included in the test cost?
The cost covers sample collection, NGS analysis, genetic counseling, clinical report, and raw data files (FASTQ, VCF).
Is home sample collection available?
Yes, free home collection is offered for online bookings across India.
Can this test diagnose melanoma?
No, it assesses genetic susceptibility. Diagnosis of melanoma requires clinical examination and biopsy.
Are there any risks associated with the test?
Risks are minimal, such as bruising from blood draw. Genetic information may have psychological implications.
How should I prepare for the test?
No fasting is required. Provide detailed clinical and family history during genetic counseling.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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