ADAMTS13 Activity Test
Also known as: ADAMTS13 Assay, von Willebrand Factor Cleaving Protease Activity Test
ADAMTS13 Activity Test test available at DNA Labs India for ₹26,000. Uses Chemiluminescent Immunoassay on Whole blood samples. Results in Reports are typically available within 1 week after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
To measure the activity level of the ADAMTS13 enzyme in the blood, aiding in the diagnosis of thrombotic thrombocytopenic purpura (TTP) and other disorders of coagulation where ADAMTS13 deficiency is suspected.
- Test Code
- 61
- Price
- ₹26,000
- Sample Type
- Whole blood
- Result Time
- Reports are typically available within 1 week after sample collection.
- Fasting Required
- Yes
- Method
- Chemiluminescent Immunoassay
Sample Collection
Overnight fasting is preferred. Ensure a duly filled Coagulation Requisition Form (Form 15) is provided. Inform the healthcare provider about any medications or recent treatments.
Method: Venipuncture
Laboratory Analysis
A healthcare professional will draw a 3 mL blood sample from a vein in your arm using a blue top sodium citrate tube. The process typically takes a few minutes.
Report Delivery
Apply pressure to the puncture site with a cotton ball to stop bleeding. You can resume normal activities, but avoid strenuous exercise for a short period.
Timeline: Reports are typically available within 1 week after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
To measure the activity level of the ADAMTS13 enzyme in the blood, aiding in the diagnosis of thrombotic thrombocytopenic purpura (TTP) and other disorders of coagulation where ADAMTS13 deficiency is suspected.
How to Prepare
- Collect 3 mL whole blood in a blue top (sodium citrate) tube
- Mix thoroughly by inversion immediately after collection
- Transport to lab within 4 hours at room temperature
- If delayed, prepare platelet-poor plasma (PPP) within 1 hour: centrifuge at 3600 rpm for 15 min, transfer supernatant, centrifuge again at 3600 rpm for 15 min, then transfer final supernatant to a labeled plastic vial and freeze immediately
- Ship frozen samples without thawing
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"The ADAMTS13 activity test is critical for diagnosing thrombotic thrombocytopenic purpura (TTP), a life-threatening condition. Low levels indicate a high risk of blood clots, and early detection allows for effective treatment with plasma exchange, significantly improving patient outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample collected in incorrect tube (not sodium citrate)
- Sample hemolyzed or clotted
- Insufficient volume (<3 mL)
- Sample not transported within stability period
- Missing or incomplete Coagulation Requisition Form (Form 15)
Understanding Your Results
Normal (>50% or 0.5-1.5 U/mL)
ADAMTS13 activity is within normal range, suggesting no significant deficiency. Clinical correlation is recommended if symptoms persist.
Low (<50% or <0.5 U/mL)
Indicates reduced ADAMTS13 activity, highly suggestive of TTP. Further testing and immediate medical consultation are advised for confirmation and treatment planning.
Very Low (<10%)
Severe deficiency often seen in acute TTP cases. Urgent treatment with plasma exchange is typically required to prevent life-threatening complications.
If your test results show low ADAMTS13 activity, or if you experience symptoms like fever, confusion, unexplained bruising, or dark urine, consult a hematologist immediately for diagnosis and management.
Limitations
- ⚠Results should be interpreted alongside clinical symptoms and other tests
- ⚠May not distinguish between inherited and acquired ADAMTS13 deficiency
- ⚠Low activity can occur in conditions other than TTP, such as sepsis or liver disease
- ⚠Test accuracy depends on proper sample preparation and stability
Risks & Considerations
- ●Minor bruising or pain at the blood draw site
- ●Rare risk of infection or excessive bleeding
- ●Fainting or dizziness in some individuals during blood draw
Interfering Factors
- ●Improper sample collection or handling, such as not using sodium citrate tube
- ●Delayed transport to laboratory beyond 4 hours at room temperature
- ●Thawing of frozen samples before analysis
- ●Hemolyzed or lipemic blood samples
- ●Recent blood transfusions or plasma exchange therapy
Compare With Similar Tests
| Test | ADAMTS13 Activity Test | PT/INR Test | aPTT Test | Platelet Count | D-dimer Test |
|---|---|---|---|---|---|
| Comparison | ADAMTS13 Activity Test |
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