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Amino Acids Quantitative Urine: 45 Amino Acids / Full Panel Test

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Amino Acids Quantitative Urine: 45 Amino Acids / Full Panel Test

Short Name: Urine Amino Acids Full Panel

Also known as: Urine Amino Acid Profile, Quantitative Urine Amino Acid Test, Amino Acidopathy Screening Urine, Full Amino Acid Panel Urine, 45 Amino Acid Urine Test

Amino Acids Quantitative Urine: 45 Amino Acids / Full Panel Test test available at DNA Labs India for ₹7,500. Uses Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) on Urine samples. Results in Results are typically available within 3 working days from sample receipt at the laboratory. Samples accepted on Monday and Wednesday by 5 PM.. Free home collection in 300+ cities across India.

PediatricianAll ages including neonates🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Ramarao Paidisetty

Dr Ramarao Paidisetty

Consultant Biochemist · Reg: 21504

Last reviewed: September 7, 2026

Overview

The primary purpose of the Amino Acids Quantitative Urine Full Panel test is to screen for, diagnose, and monitor inborn errors of metabolism (IEM) that result in abnormal amino acid levels. This test aids clinicians in identifying the specific amino acid or group of amino acids that are elevated or deficient, thereby guiding further confirmatory testing and treatment planning. It is used to diagnose conditions including Phenylketonuria (PKU), Maple Syrup Urine Disease (MSUD), Homocystinuria, Tyrosinemia, Cystinuria, Hartnup disease, and various other aminoacidopathies and organic acidemias. The test is also useful for monitoring the effectiveness of dietary therapy in patients with known metabolic disorders.

Test Code
107
CPT Code
82139
ICD Code
E70-E80
Price
₹7,500
Sample Type
Urine
Result Time
Results are typically available within 3 working days from sample receipt at the laboratory. Samples accepted on Monday and Wednesday by 5 PM.
Fasting Required
No
Method
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Step 1

Sample Collection

Clinical details and complete drug history must accompany the sample. No specific fasting is required, but dietary protein intake should be noted. Ensure the collection container is sterile and properly labeled.

Method: Clean-catch midstream urine collection

Step 2

Laboratory Analysis

Collect the first morning urine sample using clean-catch midstream technique. Use a sterile screw-capped container. A minimum of 2 mL (5 mL preferred) aliquot is required.

Step 3

Report Delivery

After collection, the urine sample should be refrigerated immediately (2-8°C) if not transported to the lab within 6 hours. Frozen samples remain stable for up to 2 weeks. Ensure the sample is transported with cold packs or in frozen state.

Timeline: Results are typically available within 3 working days from sample receipt at the laboratory. Samples accepted on Monday and Wednesday by 5 PM.

Patient Instructions

1
Before the Test:No specific fasting is required. However, inform your doctor about all medications, supplements, and recent dietary changes, as these can affect amino acid levels. Clinical details and a complete drug history must accompany the sample for accurate interpretation. Collect first morning urine for best results.
2
During the Test:The test involves non-invasive urine collection. Collect a first morning urine sample using clean-catch midstream technique into a sterile screw-capped container. A minimum of 2 mL (5 mL preferred) is required. The sample will be processed at the DNA Labs India laboratory using LC-MS/MS technology.
3
After the Test:After sample collection, refrigerate the sample immediately if it cannot be transported within 6 hours. Results will be available within 3 days through the online portal, email, or WhatsApp. No post-collection precautions are necessary for the patient. Discuss results with your doctor for interpretation and next steps.

About This Test

Who Should Get This Test

The primary purpose of the Amino Acids Quantitative Urine Full Panel test is to screen for, diagnose, and monitor inborn errors of metabolism (IEM) that result in abnormal amino acid levels. This test aids clinicians in identifying the specific amino acid or group of amino acids that are elevated or deficient, thereby guiding further confirmatory testing and treatment planning. It is used to diagnose conditions including Phenylketonuria (PKU), Maple Syrup Urine Disease (MSUD), Homocystinuria, Tyrosinemia, Cystinuria, Hartnup disease, and various other aminoacidopathies and organic acidemias. The test is also useful for monitoring the effectiveness of dietary therapy in patients with known metabolic disorders.

How to Prepare

  • Collect first morning urine sample using clean-catch midstream technique
  • Use a sterile screw-capped container provided by DNA Labs India
  • Minimum volume required: 2 mL; preferred volume: 5 mL
  • No preservative is required for the sample
  • Label the container clearly with patient name, date, and time of collection
  • Refrigerate the sample at 2-8°C immediately after collection
  • Clinical details and medication history form must accompany the sample
  • Ship the sample refrigerated (with cold packs) or frozen to the laboratory

Doctor's Notes

Reviewed by — MBBS, MD (Biochemistry) · Reg. No. 21504

"Quantitative urine amino acid analysis by LC-MS/MS is an essential first-line investigation in the evaluation of suspected inborn errors of metabolism. This comprehensive 45-amino-acid panel detects both deficiency and excess states, enabling early diagnosis of conditions such as Phenylketonuria, Maple Syrup Urine Disease, Homocystinuria, and other aminoacidopathies. Early detection through this test allows for timely dietary and medical interventions that can significantly improve long-term neurodevelopmental outcomes in affected children. I recommend this test for any child presenting with unexplained developmental delay, seizures, unusual body odor, or metabolic acidosis."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeUrine
Sample Volume5 mL (2 mL minimum) aliquot of first morning urine
ContainerSterile screw-capped container
Collection MethodClean-catch midstream urine collection

Sample Stability

Room Temperature (25°C)Up to 6 hours
Refrigerated (2-8°C)Up to 48 hours
Frozen (-20°C)Up to 2 weeks
Sample Rejection Criteria:
  • Sample received without clinical details or drug history
  • Urine sample collected in a non-sterile or improperly labeled container
  • Sample volume less than 2 mL
  • Sample left at room temperature for more than 6 hours without refrigeration
  • Visible contamination with fecal matter or other substances
  • Sample received frozen but thawed during transit with evidence of bacterial contamination

Understanding Your Results

The Amino Acids Quantitative Urine Full Panel measures the urinary excretion of 45 amino acids and related compounds. Results are typically expressed as µmol per mmol of creatinine to account for variations in urine concentration. Elevated levels of specific amino acids may indicate a block in the corresponding metabolic pathway due to an enzyme deficiency, characteristic of inborn errors of metabolism. Decreased levels may suggest nutritional deficiencies or increased renal reabsorption. All results must be interpreted in the context of the patient's clinical presentation, age, dietary intake, medication use, and corroborating investigations such as plasma amino acid analysis and organic acid profiling.
📊

Markedly elevated Phenylalanine (Phe) with elevated Phe/Tyrosine ratio

Recommendation: Confirm with plasma amino acids and genetic testing; urgent referral to metabolic specialist

📊

Elevated Leucine, Isoleucine, and Valine (branched-chain amino acids) with presence of alloisoleucine

Recommendation: Immediate metabolic emergency; urgent plasma confirmation and genetic testing required

📊

Presence of Homocystine in urine with elevated Methionine

Recommendation: Confirm with plasma homocysteine levels and genetic testing; dietary and vitamin B6 therapy assessment

📊

Markedly elevated Tyrosine (Tyr)

Recommendation: Confirm with plasma amino acids, urine succinylacetone, and genetic testing

📊

Elevated Glycine (Gly) in urine

Recommendation: Evaluate CSF/plasma glycine ratio and organic acid analysis

📊

Elevated Cystine (Cys) along with Lysine, Arginine, and Ornithine

Recommendation: Renal imaging for kidney stones; increased fluid intake and alkalinization therapy

📊

Elevated Glutamine with low Citrulline

Recommendation: Urgent ammonia levels, plasma amino acids, and genetic testing

⚠️ When to Consult a Doctor:

Consult your doctor or a metabolic specialist immediately if the test results show abnormal amino acid levels. Early consultation is especially critical for infants and children presenting with developmental delays, seizures, unusual body odor, lethargy, vomiting, or feeding difficulties. Inborn errors of metabolism are medical emergencies that require prompt intervention to prevent irreversible organ damage, particularly to the brain and kidneys. If you have a family history of metabolic disorders or are in a consanguineous relationship, genetic counseling is also recommended.

Limitations

  • ⚠This test measures amino acid levels in urine and may not fully reflect plasma or tissue amino acid concentrations
  • ⚠Results should always be interpreted in conjunction with clinical findings, plasma amino acid analysis, and other metabolic investigations
  • ⚠Certain rare amino acid disorders may require additional confirmatory testing such as enzyme assays or genetic testing
  • ⚠Single random urine collection may not capture intermittent metabolic abnormalities; first morning urine is preferred
  • ⚠Premature infants may have different amino acid excretion patterns that require age-matched reference ranges

Risks & Considerations

  • ●This is a non-invasive urine test and carries no physical risks to the patient
  • ●There is no risk of infection or discomfort associated with sample collection
  • ●False-positive or false-negative results are possible, requiring clinical correlation and repeat testing

Interfering Factors

  • ●Dietary intake of protein-rich foods prior to sample collection may affect amino acid levels
  • ●Certain medications including valproic acid, corticosteroids, and antibiotics can alter amino acid excretion
  • ●Severe dehydration or overhydration can concentrate or dilute amino acid levels in urine
  • ●Sample contamination with fecal matter or improper collection technique
  • ●Bacterial growth in urine if sample is not refrigerated promptly may degrade certain amino acids

Compare With Similar Tests

TestAmino Acids Quantitative Urine: 45 Amino Acids / Full Panel TestPlasma Amino Acids QuantitativeNewborn Screening (Tandem Mass Spectrometry)Organic Acids Urine Test
ComparisonAmino Acids Quantitative Urine: 45 Amino Acids / Full Panel Test

Frequently Asked Questions

What is the Amino Acids Quantitative Urine Full Panel test?
The Amino Acids Quantitative Urine Full Panel test is an advanced diagnostic test that quantitatively measures 45 different amino acids and related compounds in a urine sample. It is primarily used to diagnose inborn errors of metabolism—genetic disorders that affect the body's ability to process amino acids. The test is performed using LC-MS/MS technology at DNA Labs India.
Why is this test recommended for my child?
Your doctor may recommend this test if your child shows symptoms such as developmental delays, intellectual disability, seizures, unusual body odor, failure to thrive, vomiting, or lethargy. It may also be recommended as a follow-up to abnormal newborn screening results, or if there is a family history of inborn errors of metabolism. Early diagnosis through this test can lead to timely treatment and better outcomes.
How is the urine sample collected for this test?
A first morning urine sample is collected using a clean-catch midstream technique into a sterile screw-capped container. A minimum of 2 mL (5 mL preferred) is required. No preservative is needed. The sample should be refrigerated immediately after collection and transported to the lab on cold packs or in a frozen state.
Does my child need to fast before this test?
No, specific fasting is not required for this test. However, it is important to document the child's dietary intake and any medications being taken, as these can influence amino acid levels. This information should accompany the sample for accurate interpretation of results.
What is the cost of the Amino Acids Quantitative Urine Full Panel test?
The cost of the Amino Acids Quantitative Urine Full Panel test at DNA Labs India is Rs 7500.0 (INR). This price includes free home sample collection for online bookings across India and digital report delivery.
How long does it take to get the results?
Results are typically available within 3 working days from the date the sample is received at the laboratory. Samples are accepted on Monday and Wednesday by 5 PM. Reports are delivered via the online portal, email, or WhatsApp.
What conditions can this test detect?
This test can detect a wide range of inborn errors of metabolism including Phenylketonuria (PKU), Maple Syrup Urine Disease (MSUD), Homocystinuria, Tyrosinemia, Cystinuria, Nonketotic Hyperglycinemia, Hartnup disease, and various other aminoacidopathies and organic acidemias.
Is this test available for adults as well?
Yes, while this test is most commonly ordered for infants and children suspected of having inborn errors of metabolism, it can also be performed on adults when clinically indicated. Amino acid metabolism disorders can present at any age.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection for the Amino Acids Quantitative Urine Full Panel test. This service is available across numerous cities in India including Mumbai, Delhi, Bangalore, Hyderabad, Chennai, Kolkata, Pune, and many more. You can book online for home collection.
Can medications affect the test results?
Yes, certain medications including valproic acid, corticosteroids, antibiotics, and amino acid supplements can affect urinary amino acid levels. It is essential to provide a complete medication history along with the sample so that the interpreting clinician can account for potential drug-related effects.
What should I do if the test results are abnormal?
If your test results show abnormal amino acid levels, consult your doctor or a metabolic/genetic specialist immediately. Abnormal results may require confirmatory testing such as plasma amino acid analysis, organic acid profiling, enzyme assays, or genetic testing. Early intervention is critical for managing inborn errors of metabolism effectively.
How is this test different from a plasma amino acids test?
The urine amino acids test measures the excretion of amino acids in urine, reflecting the body's metabolic processing and renal handling of amino acids. The plasma amino acids test measures circulating levels in the blood. Both tests provide complementary information, and doctors often order them together for a comprehensive metabolic evaluation. The urine test is non-invasive and particularly useful for detecting amino acid transport defects in the kidney.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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