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AML FISH PANEL (FISH [AML/ETO, inv(16), PML/RARA, MLL]) Test

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AML FISH PANEL (FISH [AML/ETO, inv(16), PML/RARA, MLL]) Test

Short Name: AML FISH Panel

Also known as: AML FISH Panel, FISH for AML, Leukemia FISH Panel

AML FISH PANEL (FISH [AML/ETO, inv(16), PML/RARA, MLL]) Test test available at DNA Labs India for ₹14,850. Uses Fluorescent In Situ Hybridization (FISH) on Bone marrow / Peripheral blood samples. Results in Reports are typically available within 10 days after the sample is received by the laboratory.. Free home collection in 300+ cities across India.

Genetic🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of the AML FISH panel is to detect specific chromosomal abnormalities that aid in the diagnosis, prognosis, and therapeutic management of acute myeloid leukemia. Identifying these genetic alterations helps classify AML subtypes, guide treatment choices, and predict patient outcomes.

Test Code
6030
CPT Code
88271; 88275; 88291
ICD Code
C92.00
Price
₹14,850
Sample Type
Bone marrow / Peripheral blood
Result Time
Reports are typically available within 10 days after the sample is received by the laboratory.
Fasting Required
No
Method
Fluorescent In Situ Hybridization (FISH)
Step 1

Sample Collection

No special preparation is required. However, inform your doctor about any medications or recent treatments. A doctor's prescription is mandatory for this test.

Method: Venipuncture or Bone Marrow Aspiration

Step 2

Laboratory Analysis

The sample (bone marrow or peripheral blood) will be collected by a trained phlebotomist or clinician. For bone marrow aspiration, local anesthesia may be used. The procedure is generally safe and takes about 15-20 minutes.

Step 3

Report Delivery

After blood collection, you can resume normal activities. If bone marrow aspiration was performed, you may experience mild soreness at the site; apply ice and avoid strenuous activity for 24 hours. Contact your doctor if you notice excessive bleeding or signs of infection.

Timeline: Reports are typically available within 10 days after the sample is received by the laboratory.

Patient Instructions

1
Before the Test:No special preparation required. Ensure you have a doctor's prescription. Inform your doctor about any anticoagulant medications.
2
During the Test:Sample collection is quick and minimally invasive. For bone marrow aspiration, you may feel a sharp pinch; local anesthesia is used to minimize discomfort.
3
After the Test:You can resume normal activities immediately. If bone marrow biopsy was performed, keep the site clean and dry for 24 hours.

About This Test

Who Should Get This Test

The purpose of the AML FISH panel is to detect specific chromosomal abnormalities that aid in the diagnosis, prognosis, and therapeutic management of acute myeloid leukemia. Identifying these genetic alterations helps classify AML subtypes, guide treatment choices, and predict patient outcomes.

How to Prepare

  • Bone marrow aspirate: Collect in sodium heparin vacutainer, transport immediately at room temperature.
  • Peripheral blood: Collect 2 ml in sodium heparin vacutainer, transport immediately at room temperature.
  • Do not refrigerate or freeze the sample.
  • Label the sample with patient name, date, and time of collection.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"The AML FISH panel is essential for risk stratification and targeted therapy selection in acute myeloid leukemia. Early detection of these genetic markers significantly influences treatment decisions and prognosis."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBone marrow / Peripheral blood
Sample Volume2 ml
ContainerSodium Heparin Vacutainer
Collection MethodVenipuncture or Bone Marrow Aspiration

Sample Stability

Room temperature (20-25°C): 24 hours
Refrigerated (2-8°C): Not recommended
Frozen: Not recommended
Sample Rejection Criteria:
  • Clotted or hemolyzed sample
  • Incorrect anticoagulant (e.g., EDTA)
  • Sample received after 48 hours of collection
  • Inadequate volume (<1 ml)
  • Unlabeled or mislabeled sample

Understanding Your Results

The AML FISH panel results are reported as positive or negative for each of the four genetic abnormalities. A positive result indicates the presence of the specific translocation or inversion, which has diagnostic and prognostic implications. Interpretation should be done by a qualified geneticist or oncologist in the context of the patient's clinical presentation and other laboratory findings.
📊

t(8;21) (AML1/ETO)

Favorable risk; associated with AML with maturation (M2). High remission rate with standard chemotherapy.

📊

inv(16) (CBFB/MYH11)

Favorable risk; associated with AML with abnormal eosinophils (M4Eo). Good response to high-dose cytarabine.

📊

t(15;17) (PML/RARA)

Diagnostic of APL (M3). Medical emergency; treat with ATRA and arsenic trioxide. High cure rate if treated promptly.

📊

MLL (11q23) rearrangement

Intermediate to poor risk; common in therapy-related AML and infant AML. May require allogeneic stem cell transplant.

⚠️ When to Consult a Doctor:

Consult your oncologist or hematologist if you experience symptoms such as persistent fatigue, unexplained fever, easy bruising, or bone pain. Early diagnosis and genetic testing are crucial for effective AML management.

Limitations

  • ⚠FISH only detects targeted abnormalities; other genetic mutations may be missed
  • ⚠Results may be false negative if the abnormal clone is below the detection threshold
  • ⚠Not a substitute for karyotyping or comprehensive molecular profiling
  • ⚠Requires clinical correlation with morphology and other tests

Risks & Considerations

  • ●Minimal risk of bleeding or infection at the collection site
  • ●Bone marrow aspiration may cause temporary pain or discomfort
  • ●Rare risk of nerve damage or hematoma (very low)

Interfering Factors

  • ●Hemolyzed or clotted samples may affect FISH analysis
  • ●Inadequate sample volume or low cellularity
  • ●Delayed transport leading to cell degradation
  • ●Prior chemotherapy or radiation may alter cytogenetic findings
  • ●Presence of constitutional chromosomal abnormalities

Compare With Similar Tests

TestAML FISH PANEL (FISH [AML/ETO, inv(16), PML/RARA, MLL])AML FISH PanelConventional Cytogenetics (Karyotyping)
ComparisonAML FISH PANEL (FISH [AML/ETO, inv(16), PML/RARA, MLL])

Frequently Asked Questions

What is the AML FISH panel?
The AML FISH panel is a genetic test that detects specific chromosomal abnormalities (translocations and inversions) commonly found in acute myeloid leukemia (AML). It uses fluorescent in situ hybridization (FISH) to identify four key genetic markers: AML1/ETO (t(8;21)), inv(16), PML/RARA (t(15;17)), and MLL (11q23) rearrangements.
Why is the AML FISH panel important?
This panel helps in diagnosing AML subtypes, determining prognosis, and guiding treatment decisions. For example, detecting t(15;17) confirms acute promyelocytic leukemia (APL), which requires urgent targeted therapy with ATRA and arsenic trioxide.
What is the cost of the AML FISH panel at DNA Labs India?
The cost is INR 14,850, which includes home sample collection, test kit, analysis, and interpretation. We offer free home sample collection across major cities in India.
What sample is required for the AML FISH panel?
The test can be performed on bone marrow aspirate or peripheral blood. The sample should be collected in a sodium heparin vacutainer and transported immediately to the laboratory.
Do I need to fast before the AML FISH panel?
No, fasting is not required for this test. You can eat and drink normally before sample collection.
How long does it take to get the results?
Results are typically available within 10 days after the sample is received by the laboratory.
Is a doctor's prescription required for this test?
Yes, a doctor's prescription is mandatory for the AML FISH panel. However, it is not applicable for surgery or pregnancy cases or for individuals planning to travel abroad.
What does a positive result for t(15;17) mean?
A positive result for t(15;17) indicates the presence of the PML/RARA fusion gene, which is diagnostic of acute promyelocytic leukemia (APL). This is a medical emergency and requires immediate treatment with ATRA and arsenic trioxide.
Can the AML FISH panel be used for monitoring minimal residual disease?
Yes, FISH can be used to monitor minimal residual disease (MRD) in patients with known genetic abnormalities, helping to assess treatment response and detect early relapse.
Are there any risks associated with the test?
The test is generally safe. For blood collection, there is minimal risk of bruising or infection. Bone marrow aspiration may cause temporary discomfort, but serious complications are rare.
Does the test detect all genetic abnormalities in AML?
No, the AML FISH panel only detects the four specific abnormalities mentioned. Other genetic mutations (e.g., FLT3, NPM1) require additional molecular testing.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection for online bookings across multiple cities including Mumbai, Delhi, Bangalore, Hyderabad, and many more.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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