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AML Prognostic Panel (Cytogenetics + PCR) (AML/ETO, INV[16], PML/RARA, FLT3, NPM1, CEBPA) Test

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AML Prognostic Panel (Cytogenetics + PCR) (AML/ETO, INV[16], PML/RARA, FLT3, NPM1, CEBPA) Test

Short Name: AML Prognostic Panel

Also known as: AML Prognostic Panel, AML Mutation Panel, AML Cytogenetic and Molecular Panel

AML Prognostic Panel (Cytogenetics + PCR) (AML/ETO, INV[16], PML/RARA, FLT3, NPM1, CEBPA) Test test available at DNA Labs India for ₹21,000. Uses Cell culture, End point PCR on Bone marrow / Peripheral blood samples. Results in Results are typically available within 5-7 working days after the sample reaches the laboratory.. Free home collection in 300+ cities across India.

Cytogenetics + PCR🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of this panel is to provide a comprehensive genetic profile of AML to guide prognosis and treatment decisions. It identifies specific chromosomal translocations and gene mutations that influence risk category (favorable, intermediate, adverse) and helps in selecting appropriate therapy, including targeted agents. It also aids in monitoring minimal residual disease (MRD) and predicting relapse risk.

Test Code
6035
CPT Code
CPT 81450
ICD Code
C92.00
Price
₹21,000
Sample Type
Bone marrow / Peripheral blood
Result Time
Results are typically available within 5-7 working days after the sample reaches the laboratory.
Fasting Required
No
Method
Cell culture, End point PCR
Step 1

Sample Collection

No special preparation required. Inform your doctor about any medications you are taking. For bone marrow aspiration, local anesthesia may be used.

Method: Venipuncture / Bone marrow aspiration

Step 2

Laboratory Analysis

Blood sample is drawn from a vein in your arm. For bone marrow, a needle is inserted into the hip bone to collect a small amount of marrow. You may feel a brief pain or pressure.

Step 3

Report Delivery

Apply pressure to the puncture site to stop bleeding. Keep the area clean and dry. You may resume normal activities immediately.

Timeline: Results are typically available within 5-7 working days after the sample reaches the laboratory.

Patient Instructions

1
Before the Test:No special preparation required. Inform your doctor about any medications you are taking.
2
During the Test:Blood sample is drawn from a vein in your arm. For bone marrow, a needle is inserted into the hip bone to collect a small amount of marrow. You may feel a brief pain or pressure.
3
After the Test:Apply pressure to the puncture site to stop bleeding. Keep the area clean and dry. You may resume normal activities immediately.

About This Test

Who Should Get This Test

The purpose of this panel is to provide a comprehensive genetic profile of AML to guide prognosis and treatment decisions. It identifies specific chromosomal translocations and gene mutations that influence risk category (favorable, intermediate, adverse) and helps in selecting appropriate therapy, including targeted agents. It also aids in monitoring minimal residual disease (MRD) and predicting relapse risk.

How to Prepare

  • Use EDTA vacutainer for blood sample
  • Transport immediately at room temperature (cool pack recommended)
  • Bone marrow sample should be collected by a qualified professional
  • Label the sample with patient name and date of birth

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"This panel is essential for risk stratification and treatment planning in AML. Early testing can significantly impact prognosis."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBone marrow / Peripheral blood
Sample Volume3 ml
ContainerEDTA Vacutainer
Collection MethodVenipuncture / Bone marrow aspiration

Sample Stability

Blood: 24 hours at room temperature
Blood: 48 hours at 2-8°C
Bone marrow: 24 hours at room temperature
Sample Rejection Criteria:
  • Clotted or hemolyzed sample
  • Incorrect container (e.g., heparin instead of EDTA)
  • Insufficient volume
  • Sample not transported within recommended time

Understanding Your Results

The results of this panel should be interpreted by a qualified oncologist or geneticist. Presence of certain mutations (e.g., NPM1, CEBPA) may indicate favorable prognosis, while FLT3-ITD is associated with adverse risk. Cytogenetic abnormalities like t(8;21) and inv(16) are favorable, while complex karyotype is adverse.
📊

Favorable risk; associated with t(8;21), good response to cytarabine-based therapy

📊

Favorable risk; associated with CBFB-MYH11, high remission rate

📊

Diagnostic of Acute Promyelocytic Leukemia (APL); highly responsive to ATRA and arsenic trioxide

📊

Adverse risk; associated with higher relapse risk; may benefit from FLT3 inhibitors (e.g., midostaurin)

📊

Favorable risk (if without FLT3-ITD); associated with good response to induction therapy

📊

Favorable risk; associated with better overall survival

⚠️ When to Consult a Doctor:

Consult your oncologist if you have symptoms such as persistent fever, fatigue, easy bruising, or unexplained weight loss. Early diagnosis and treatment are critical for AML.

Limitations

  • ⚠This panel does not cover all possible AML-related mutations
  • ⚠Results should be interpreted in conjunction with clinical findings and other tests
  • ⚠Cytogenetic analysis may miss small deletions or mutations detectable by PCR
  • ⚠Bone marrow sample is preferred for higher sensitivity
  • ⚠Not a screening test for healthy individuals

Risks & Considerations

  • ●Bruising or bleeding at the puncture site
  • ●Infection (rare)
  • ●Discomfort during bone marrow aspiration

Interfering Factors

  • ●Hemolysis or clotting of blood sample
  • ●Inadequate sample volume
  • ●Delayed transport leading to cell degradation
  • ●Recent blood transfusion (may dilute patient cells)
  • ●Concurrent infections or inflammation

Compare With Similar Tests

TestAML Prognostic Panel (Cytogenetics + PCR) (AML/ETO, INV[16], PML/RARA, FLT3, NPM1, CEBPA)AML Minimal Residual Disease (MRD) PanelAML Comprehensive Mutation Panel (NGS)Cytogenetic Analysis (Karyotype)FLT3 Mutation Analysis
ComparisonAML Prognostic Panel (Cytogenetics + PCR) (AML/ETO, INV[16], PML/RARA, FLT3, NPM1, CEBPA)

Frequently Asked Questions

What is the AML Prognostic Panel?
It is a comprehensive test that combines cytogenetic and PCR analysis to detect key genetic abnormalities in AML, aiding in diagnosis, prognosis, and treatment planning.
What is the cost of the AML Prognostic Panel at DNA Labs India?
The cost is INR 21,000, which includes home sample collection and report delivery.
What sample is required for this test?
Bone marrow or peripheral blood sample is required. Bone marrow is preferred for higher sensitivity.
Do I need to fast before the test?
No, fasting is not required for this test.
How long does it take to get results?
Results are typically available within 5-7 working days after the sample reaches the laboratory.
What genetic abnormalities does this panel detect?
It detects AML/ETO, INV[16], PML/RARA, FLT3, NPM1, and CEBPA abnormalities.
Is home sample collection available?
Yes, we offer free home sample collection for online bookings across major cities in India.
Can this test be done without a doctor's prescription?
A doctor's prescription is required for this test, except for surgery or pregnancy cases or those planning to travel abroad.
What is the significance of FLT3 mutation in AML?
FLT3-ITD mutation is associated with adverse prognosis and higher relapse risk. It helps in selecting targeted therapy like midostaurin.
What is the role of NPM1 mutation in AML?
NPM1 mutation is generally associated with favorable prognosis, especially when FLT3-ITD is absent. It is a common mutation in AML.
How should the sample be transported?
The sample should be transported immediately, preferably in a cool pack, to maintain cell viability.
Are there any risks associated with bone marrow aspiration?
Risks include bruising, bleeding, infection (rare), and discomfort at the puncture site.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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